22. Respiration Flashcards

1
Q

What is ventilation?

A

Movement of the medium (air, water) over a gas exchange surfaces

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2
Q

What does respiration refer to?

A
  • Oxidation of the end products of glycolysis (by 02 in eukaryotes)
  • Breathing or physiological respiration
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3
Q

Is it better to breathe from oxygen in water or air?

A
  • There is 21% O2 in the atmosphere
  • Atmospheric pressure changes with altitude, higher the altitude the lower the pressure
  • Fewer molecules of oxygen/ litre air
  • In still water water is not in contact with air and contains less O2
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4
Q

What is hypoxia?

A
  • Low O2 in blood or environment
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5
Q

What is anoxia?

A
  • Complete absence of O2 in the environment
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6
Q

What is hypercapnia?

A

Excessively high CO2 levels in blood

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7
Q

What is partial pressure in reference to gas?

A

Component of total pressure contributed by a single (free) gas within a mixture of gases

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8
Q

Why is air a better respiratory medium than water?

A
  • Oxygen diffuses 8000 times more rapidly in air than in water
  • To move medium over a gas exchange site, more energy is required to mover water than air (water is 800x denser and 50x more viscous than air)
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9
Q

How does respiration occur in small animals?

A
  • Small animals can take up 02 directly from the environment through the body surface
  • Simple diffusion distributes 02 throughout the body, into cells and throughout their cytoplasm
  • No specialised respiratory structures required
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10
Q

When is diffusional transport of 02 effective?

A

Diffusional transport of 02 is only efficient if distance is 1mm at most

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11
Q

What are the greater demands for the respiratory system in larger more complex animals?

A
  • Higher cellular metabolic rate
  • Reduction in total surface area available for gas exchange
  • Large, multicellular organisms are too large for diffusion

Thus both aquatic and terrestrial animals have evolved respiratory systems with a large surface area to maintain adequate respiratory supply of oxygen to their tissues

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12
Q

What is Fick’s law?

A

Rate of gas exchange = (surface area x concentration gradient x diffusion coefficient)/diffusion distance

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13
Q

How is gas exchange maximised (based on the equation?

A
  • Increase surface area
  • Increase pressure difference
  • decrease diffusion distance
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14
Q

If terrestrial animals breath air then why does solubility of gases matter?

A
  • Matters because it is moist within the lungs so gases must dissolve through a layer of fluid to get into the lungs, and must stay dissolved when they are in the blood
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15
Q

What characteristics does an exchange site have?

A
  • A large surface area
  • Small diffusion distance (i.e thin epithelium/endothelium) between the respiratory medium and the blood or blood and tissues
  • A highly vascularised respiratory surface
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16
Q

Where do respiratory gases diffuse?

A

Across the exchange site (the respiratory epithelium and capillary endothelium)

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17
Q

How do you increase transport of O2 to tissues?

A

High surface area to volume ratio, ensure surfaces are thin and highly vascularised with lots of blood vessels

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18
Q

What is the purpose of a ventilation system?

A
  • It is to keep a constant supply to medium moving across the respiratory exchange site
  • Improves rate of gas exchange
  • Ensures that fresh supplies of O2 rich medium are supplies to the exchange surface
19
Q

What is the structure of the ventilation system in fish?

A

Mouth and operculum allow unidirection flow of water across gills

20
Q

What is the structure of the ventilation system in frogs?

A

Buccal cavity (2 phases of lung ventilation, tidal flow of air)

21
Q

What is the purpose of air sacs?

A

System for two cycles of inhalation and exhalation (unidirectional air flow)

22
Q

What is the purpose of the internal transport (circulatory system)?

A
  • It moves the dissolved O2 from the exchange site to respiring tissues
  • Also transports CO2 away from the metabolising tissues
23
Q

Why is the internal transport (circulatory) system essential?

A

Because diffusion is exceedingly slow over even moderate distances.

24
Q

What is the purpose of the circulatory system?

A

The heart acts as a pump to increase the movement of blood around the body

25
How is the oxygen carrying capacity of blood increased?
By respiratory pigments (blood pigments)
26
What are respiratory pigments?
- Complexes of proteins and metal ions | - Have a characteristic colour that changes when it binds O2
27
What is the difference between haemoglobin and haemocyanin?
- Haemoglobin is dark and goes bright red when oxygenated | - Haemocyanin is colourless and goes blue when oxygenated
28
How do respiratory pigments help oxygen bind?
- O2 binds reversible to a metal ion associated with the protein chain of the respiratory pigment
29
What is haemoglobin?
The main vertebrate respiratory pigment - Each heme group can combine with one O2 molecule There are 4 heme units = 4 x oxygen molecules per b
30
When does sickle cell anaemia occur?
- When an abnormal form of haemoglobin (HbS) is produced) | - HbS molecules clump together making red blood cells sticky and causing them to form into a curved sickle shape
31
What is the implication of sickle cell anaemia?
- Sickle cells can clog blood vessels and deprive the body’s tissues and organs of oxygen - Anaemia is when the body’s number of red blood cells (or amount of haemoglobin) falls below normal - Anaemic people often feel weak and tire more easily
32
What is positive cooperatively?
Binding of the first oxygen molecule increases the binding affinity of subsequent O2
33
What happens if there is a high pressure of oxygen in the blood?
A large amount of oxygen is bound to Hb
34
What happens if there is a low pressure of oxygen in the blood?
Only a small amount of O2 is bound to Hb
35
How does the affinity of respiratory pigments for O2 depend on different factors?
- Type of respiratory pigment, eg myoglobin, Llama haemoglobin - pH of blood circulating through active tissues has a lower pH and H+ ions bind to the haemoglobin molecule in place of O2, lowering the affinity for O2 (the Bohr effect) - BPG lowers the affinity for O2
36
What is 2,3-bisphosphoglyceric acid (BPG)?
- Mammalian glycolysis metabolite found in RBCs
37
How does BPG interact with Hb?
Reversibly combines with partly deoxygenated Hb and LOWERS its affinity for O2, thus O2 releases the remaining oxygen (O2 binding curve shifts right)
38
How does high altitude affect BPG?
- Level of BPG in RBCs increases at high altitude or with increased exercise - Helps Hb deliver more O2 to tissues where it is most needed - 2,3 BPG lost during blood storage
39
How does respiratory pigment in muscle cells affect oxygen binding?
- Muscle cells have the own O2 binding molecule (myoglobin) - It has a higher affinity than Hb for O2 - Binds O2 at Pressure of O2 values much lower than HB - Provides an O2 reserve in muscles
40
How many subunits does myoglobin have?
It is monomeric, only holds one oxygen
41
What are the three ways in which carbon dioxide is transported in the blood?
- 10% dissolved in plasma - 30% reversibly bound to Hb (carbaminohaemoglobin) - 60% are bicarbonate
42
What is the carbon equation that occurs inside RBCs?
CO2 + H2O---> H2CO3 ---> H+ + HCO3-
43
How does Carbon dioxide conversion in the blood affect the equation?
Converting CO2 to H2CO3 decreases the pressure of CO2 in the blood - causing more CO2 to diffuse out of the tissues
44
What are the two ways in which carbon dioxide is transported in the blood?
1. Chloride/bicarbonate exchange (‘chloride shift’) 2. H+ buffering by haemoglobin (Hb + H+ = HHb) Watch YouTube vid or read textbook for this