22 - PHARMACOLOGY OF PAIN AND INFLAMMATION

Question 1

SALICYLATES

Answer 1

THEY ARE A CHEMICAL GROUP OF DRUGS EXTRACTED FROM BARK OF SALIX ALBA
THEY INHIBIT COX IRREVERSIBÑY
ASA IS AN ESTER METABOLIZED TO SALICYLIC ACID, THERE ARE OTHER REDIATIES

Question 2

FROMULATIONS OF SALICYLATES

Answer 2

• BUFFERED-EFFERVESCENT FORMULATIONS; THEY CONTAIN CITRIC ACID AND SODIUM BICARBONATE THAT ACT AS A BUFFER
• CONTROLLED RELEASE FORMULATIONS
• FORMULATIONS FOR TOPICAL APPLICATION

Question 3

HIGH DOSES OF SALICYLATES

Answer 3

THEY INHIBIT THE REABSORPTION OF URATE BEHAVING LIKE URICOSURIC

Question 4

ACTIVITY OF ASA

Answer 4

IT HAS PLATELET ANTIAGGREGATORY ACTIVITY AT DOSES LOWER THAN THE ANALGESIC (COX1 INHIBITION MORE POTENT THAN COX2)

Question 5

ACTION OF ASPIRIN WHEN IT IS TAKEN ALONE

Answer 5

IT IRREVERSIBLY INHIBITS COX-1 ACTIVIY BY ACETYLATION OF A SERINE RESIDUE IN THE ACTIVE SITE OF THE ENZYME

Question 6

ACTION OF ASPIRIN WHEN IS TAKEN WITH OTHER NSAIDS

Answer 6

WHEN IBUPROFEN AND NAPROXEN IS TAKEN PRIOR TO ASPIRIN, IT CAN OCCUPY THE ACTIVE SITE OF COX AND PREVENT ASPIRIN FROM ACETYLATING COX SERINE RESIUDES. THEIR EFFECT IS RELATIVELY TRANSIENT, NON-ASPIRIN NSAIDS BIND REVERSIBLY.

Question 7

PHARMACOKINETICS OF ASPIRIN

Answer 7

A

Question 8

CLINICAL USES OF SALYCILATES

Answer 8

B

Question 9

ADVERSE REACTIONS OF SALYCILATES

Answer 9

GI, NEURONAL AND RENAL PROBLEMS OF HYPERSENSIBILITY

SALICYLISM

REYE’S SYNDOROME

Question 10

PARA-AMINOPHENOLS, CHARACTERISTICS

Answer 10

A

Question 11

AR OF PARA-AMINOPHENOLS

Answer 11

B

Question 12

PHASES OF THE ACUTE POISONING OF PARA-AMINOPHENOLS

Answer 12

C

Question 13

INDICATIONS OF PARA-AMINOPENOLS

Answer 13

D

Question 14

PYRAZOLINE DERIVATIVES NAMES

Answer 14

METAMIZOLE (DIPYRONE) AND PROPYPHENAZONE

Question 15

PYRAZOLINE DERIVATIVES CHARACTERISTICS

Answer 15

E

Question 16

PYRAZOLINE DERIVATIVES AR

Answer 16

F

Question 17

PROPIONIC ACID DERIVATIVES CHARACTERISTCIS

Answer 17

A

Question 18

PROPIONIC ACID DERIVATIVES, USES

Answer 18

B

Question 19

FLURBIPROFEN

Answer 19

C

Question 20

AR OF PROPIONIC ACID DERIVATIVES

Answer 20

D

Question 21

CHIRALITY OF PROPIONIC ACID DERIVATIVES

Answer 21

E

Question 22

DIFFERENT SUBTYPES OF ACETIC ACID DERIVATIVES

Answer 22

1. INDOLEACETIC
2. PYRROLEACETIC
3. PHENYLACETIC

Question 23

INDOLEACETIC ACETIC ACID DERIVATIVES

Answer 23

INDOMETHACIN

Question 24

PYRROLEACETIC ACETIC ACID DERIVATIVES

Answer 24

SULINDAC, KETOROLAC

Question 25

PHENYLACETIC ACETIC ACID DERIVATIVES

Answer 25

DICLOFENAC

Question 26

INOMETHACIN CHATACTERISTICS

Answer 26

A

Question 27

INDOMETHACIN AR

Answer 27

B

Question 28

KETOROLAC CHARACTERISTICS

Answer 28

C

Question 29

KETOROLAC AR

Answer 29

D

Question 30

DICLOFENAC CHARACTERISTICS

Answer 30

E

Question 31

DICLOFENAC AR

Answer 31

F

Question 32

OXICAMS MAIN CHARACTERISTICS AND INDICATIONS

Answer 32

A

Question 33

PIROXICAM

Answer 33

A

Question 34

TENOXICAM

Answer 34

A

Question 35

MELOXICAM

Answer 35

A

Question 36

LORNOXICAM

Answer 36

A

Question 37

COXIBS

Answer 37

A