20 - CORTICOSTEROIDS Flashcards
GENERAL CHARACTERISTICS
ENDOGENOUS MOLEULES VERY LIPOPHILIC WHICH ACT AS HORMONES
THEY ARE SYNTHESIZED IN THE ADREENAL CORTEX AFTER STIMULI ARRIVING
THE MOST IMPORTAL GLUCOCORTICOID IS CORISOL AND THE MOST IMPORTANT MINERALOCORTICOID S ALDOSTERONE
MINERALOCORTICOIDS
ALDOSTERONE INCREASES THE NA+ REUPTAKE IWH INCREASED EXCRETION OF K+ AND H+
REGULATED BY THE RENIN- ANGIOTENSIN SYSTEM
DEFICIT OF MINEAROLOCORTICOIDS AND TREATMENT
ADDISON’S DISEASE; HYPONATREMINA, HYPERALKALEMIA AND REDUCED EXTRACELLULAR VOLUME
TREATED IWTH FLUDROCORTISONE
FLUODROCORTISONE
IN ORDER TO TREAT THE DEFICIT OF ALDOSTERONE; ADDISON’S DISEASE
EXCESS OF MINEAROLOCORTICOIDS AND TREATMENT
CONN’S SYNDROME (PRIMARY ALDOSTONERISM) OR SECONDARY (KIDNEY DISEASE, LIVER CIRRHOSIS OR CONGESTIVE HEART FAILURE). TREATMENT WITH SPIRONOLACTONE. IT CAUSES GYNESCOMASTIA AND IMPOTENCE. OTHER OPTION IS ESPLERENONE (LESS AR)
SPIRONOLACTONE
TO TREAT THE EXCESS OF ALDOSTERONE; GYNESCOMASTIA AND IMPOTENCE. ESPLERONE HAS LESS AR
ESPLERENONE
TO TREAT THE EXCESS OF ALDOSTERONE; ANOTHER OPTION IS SPIRONOLACTONE (GYNESCOMASTIA AND IMPOTENCE). ESPLERONE HAS LESS AR
ACTIONS OF GLUCOCORTICOIDS
A
OTHER ACTIONS OF GLUCOCORTICOIDS
B
DEFICIENCY OF GLUCOCORTICOIDS
ADDISON’S DISEASE
EXCESS OF GLUCOCORTICOIDS
CUSHING’S SYNDROME
NAME OF THE MOST COMMON CORTICOSTEROIDS
BETAMETHASONE CORTISONE, DEFLAZACORT, HYDROCORTISONE, PREDNOSOLONE, PRENISONE, METHYLPREDNISOLONE, TRIAMICINOLONE, DEXAMETASONE
THEY ARE BENEFICIAL FOR THER ANTI-INFLAMMATORY EFFECT IN CANCER PAIN AND OSTEOARTICULAR PAIN OF INFLAMMATORY ORIGIN
EFFECTS OF CORTICOSTEROIDS
METABOLIC,
VASCULAR
INFLAMMATORY
PK OF CORTICOSTEROIDS
A
INDICATIONS OF CORTICOSTEROIDS
A
