2.1.1 Parvo and Papova Viruses

Question 1

Describe the general properties of polyomavirinae.

Answer 1

Question 2

What are the different polyomaviruses that infect human?

Answer 2

Question 3

Describe the structure and genomic organization of polyomavirues.

Answer 3

Question 4

Describe the difference between the early and late gene products of the polyomaviruses.

Answer 4

Question 5

Describe the roles of the large and small T-antigens.

Answer 5

Question 6

What is the replication cycle of the polyomaviruses?

Answer 6

Question 7

Important: Describe the role of the T-antigen and its role in the p53 and Rb tumor suppressor pathways.

Answer 7

Question 8

Describe the general characteristics of the JC virus.

Answer 8

Question 9

Describ the pathogenesis of the JC/BK virus.

Answer 9

Question 10

Describe the relationship between the JC Virus and PML.

Answer 10

JC virus can lead to PML in immunocompromised patients - Demyelination of the CNS caused by destruction of the oligodendrocytes

Question 11

What are these images of?

Answer 11

PML

Question 12

Describe the characteristics of the BK virus.

Answer 12

Question 13

What is PVAN?

Answer 13

Question 14

Describe the treatments for JC/BK virus.

Answer 14

None

Question 15

Why were papilloma viruses initially so difficult to create a vaccine against?

Answer 15

Papilloma virus resistend culturing in cell culture systems

Question 16

What are the characteristics of HPV?

Answer 16

Question 17

Describe the structure and genome of the papillomaviruses.

Answer 17

Question 18

Describe the HPV replication cycle.

Answer 18

Question 19

Important: What are the mechanisms of evasion by HPV?

Answer 19

Question 20

What is condyloma acuminata?

Answer 20

Anogenital warts

Caused by HPV 6 and 11

Question 21

What is the common wart?

Answer 21

Verruca vulgaris

Caused by HPV 2 and 4

Question 22

What are plantar warts.

Answer 22

Verruca plantaris

Wart on sole of foot

HPV 1, 2, and 4

Question 23

How can immunosuppression affect size of warts?

Answer 23

Patients may be plagued with many large warts

Question 24

Describe the progression of HPV in relation to CIN 1, 2 and 3

Answer 24

Question 25

Integration of HPV into host genome results in?

Answer 25

Inactivation of E2

Question 26

Describe the roles of the E1 and E2 proteins.

Answer 26

Question 27

What is the role of the E5 protein.

Answer 27

Question 28

What is the role of the E6 protein?

Answer 28

Question 29

Describe the role of the E7 protein.

Answer 29

Question 30

Describe the HPV vaccine.

Answer 30