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Infectious Disease > 2.1.1 Parvo and Papova Viruses > Flashcards

2.1.1 Parvo and Papova Viruses Flashcards

1
Q

Describe the general properties of polyomavirinae.

A
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2
Q

What are the different polyomaviruses that infect human?

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3
Q

Describe the structure and genomic organization of polyomavirues.

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4
Q

Describe the difference between the early and late gene products of the polyomaviruses.

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5
Q

Describe the roles of the large and small T-antigens.

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6
Q

What is the replication cycle of the polyomaviruses?

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7
Q

Important: Describe the role of the T-antigen and its role in the p53 and Rb tumor suppressor pathways.

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8
Q

Describe the general characteristics of the JC virus.

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9
Q

Describ the pathogenesis of the JC/BK virus.

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10
Q

Describe the relationship between the JC Virus and PML.

A

JC virus can lead to PML in immunocompromised patients - Demyelination of the CNS caused by destruction of the oligodendrocytes

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11
Q

What are these images of?

A

PML

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12
Q

Describe the characteristics of the BK virus.

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13
Q

What is PVAN?

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14
Q

Describe the treatments for JC/BK virus.

A

None

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15
Q

Why were papilloma viruses initially so difficult to create a vaccine against?

A

Papilloma virus resistend culturing in cell culture systems

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16
Q

What are the characteristics of HPV?

A
17
Q

Describe the structure and genome of the papillomaviruses.

A
18
Q

Describe the HPV replication cycle.

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19
Q

Important: What are the mechanisms of evasion by HPV?

A
20
Q

What is condyloma acuminata?

A

Anogenital warts

Caused by HPV 6 and 11

21
Q

What is the common wart?

A

Verruca vulgaris

Caused by HPV 2 and 4

22
Q

What are plantar warts.

A

Verruca plantaris

Wart on sole of foot

HPV 1, 2, and 4

23
Q

How can immunosuppression affect size of warts?

A

Patients may be plagued with many large warts

24
Q

Describe the progression of HPV in relation to CIN 1, 2 and 3

A
25
Q

Integration of HPV into host genome results in?

A

Inactivation of E2

26
Q

Describe the roles of the E1 and E2 proteins.

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27
Q

What is the role of the E5 protein.

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28
Q

What is the role of the E6 protein?

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29
Q

Describe the role of the E7 protein.

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30
Q

Describe the HPV vaccine.

A

Infectious Disease (40 decks)

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