1.5.1 Herpesviruses Flashcards

1
Q

Describe the structure and genome of HSV-1.

A
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2
Q

Describe the relationship of herpesviruses and latency.

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3
Q

Describe the various cell receptors for the herpesviruses.

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4
Q

Describe the transcription of the herpesviruses also explain the alpha, beta and gamma proteins.

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5
Q

Describe the Lytic Virus Life Cycle for HHV-I.

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6
Q

Herpesviruses are capable of forming?

A

Multinucleated giant cells - syncytia

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7
Q

Describe the pathogenesis of HSV-1 and HSV-2.

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8
Q

Describe the epidemiology of HSV-1.

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9
Q

Describe the latency of HSV-1 and HSV-2.

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10
Q

Describe the different sites of latency of the different herpesviruses.

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11
Q

Describe the clinical manifestations of HSV-1 (HHV-1) and HSV-2 (HHV-2).

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12
Q

Describe Herpes Labialis.

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13
Q

Who is the main culprit for genital herpes?

A

HSV-2

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14
Q

Describe the typical clinical course of genital herpes.

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15
Q

What is eczema hepeticum?

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16
Q

What is herpes whitlow?

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17
Q

What is herpes gladiatorum?

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18
Q

What is herpes keratoconjunctivitis?

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19
Q

Important: Describe the relationship of herpesvirus and encephalitis.

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20
Q

Describe the characteristics of neonatal herpes.

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21
Q

Describe the characteristics of Varicella-Zoster (VZV).

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22
Q

What is the mechanism of spread of VZV?

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23
Q

What is the time course of VZV?

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24
Q

What is the difference between chickenpox and zoster?

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25
Q

Describe congenital varicella.

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26
Q

What are the different drugs used to treat HSV-1, HSV-2 and VZV?

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27
Q

What techniques can be used to make a diagnosis of HHV-1, HHV-2, or VZV?

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28
Q

What is a Tzanck smear?

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29
Q

What is the vaccine for VZV?

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30
Q

What are the 3 potential outcomes of Epstein-Barr Virus (EBV/HHV-4)?

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31
Q

Describe the pathogeneis of EBV.

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32
Q

What is the role of B and T cells in EBV pathogenesis?

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33
Q

Describe the latency of EBV.

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34
Q

What are the characteristics of infectious mononucleosis?

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35
Q

What are the characteristics cell in infectious mono?

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36
Q

What are the characteristics of Burkitt’s Lymphoma cause by EBV?

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37
Q

What is the model of the evolution of Burkitt’s lymphoma from EBV?

A
38
Q

Describe the pathogenesis of Hodgkin’s Lymphoma.

A
39
Q

What are the characteristic cells of Hodgkin’s lymphoma?

A
40
Q

How does nasopharyngeal carcinoma relate to EBV?

A
41
Q

AIDS patients infected with EBV are at risk for?

A

Oral Hairy Leukoplakia

42
Q

What can be used to make a diagnosis of EBV.

A
43
Q

Describe the different ways to interpret EBV antibody tests.

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44
Q

Describe the epidemiology of CMV?

A
45
Q
A
46
Q

What are the different outcomes of CMV infection?

A
47
Q

Describe the symptoms associated with Cytomegalic Inclusion Disease.

A
48
Q

Describe the characteristic cells in CMV.

A

Owl eye cells

49
Q

Describe the different symptoms associated with immunosuppressed patients and CMV infection.

A
50
Q

What is this an image of?

A

CMV Retinitis

51
Q

How would someone test for CMV?

A
52
Q

Describe the characteristics of HHV-6 and HHV-7.

A
53
Q

What are the characteristics of HHV-6?

A
54
Q

What is roseola infantum?

A
55
Q

What are the characteristics of HHV-8?

A
56
Q

What are these images of?

A

HHV-8 (KSHV) infection involving the oral cavity

57
Q

Describe the pathogenesis and associated diseases associated with HHV-8.

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58
Q

Describe the relationship between Kaposi’s Sarcoma and HHV-8.

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59
Q

What is classical Kaposi’s Sarcoma?

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60
Q

What is African (endemic) Kaposi’s Sarcoma?

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61
Q

Describe the characteristics of AIDS Kaposi’s Sarcoma.

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62
Q

What are the latency associated proteins associated with HHV-8 infection?

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63
Q

Describe the progression of HHV-8 infection to Kaposi’s Sarcoma or Primary Effusion lymphoma.

A