1.5.1 Herpesviruses Flashcards by Miles Sanderson

Q

Describe the structure and genome of HSV-1.

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Q

Describe the relationship of herpesviruses and latency.

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Q

Describe the various cell receptors for the herpesviruses.

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Q

Describe the transcription of the herpesviruses also explain the alpha, beta and gamma proteins.

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Q

Describe the Lytic Virus Life Cycle for HHV-I.

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Q

Herpesviruses are capable of forming?

A

Multinucleated giant cells - syncytia

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Q

Describe the pathogenesis of HSV-1 and HSV-2.

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Q

Describe the epidemiology of HSV-1.

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Q

Describe the latency of HSV-1 and HSV-2.

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Q

Describe the different sites of latency of the different herpesviruses.

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Q

Describe the clinical manifestations of HSV-1 (HHV-1) and HSV-2 (HHV-2).

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Q

Describe Herpes Labialis.

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Q

Who is the main culprit for genital herpes?

A

HSV-2

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Q

Describe the typical clinical course of genital herpes.

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Q

What is eczema hepeticum?

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Q

What is herpes whitlow?

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Q

What is herpes gladiatorum?

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Q

What is herpes keratoconjunctivitis?

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Q

Important: Describe the relationship of herpesvirus and encephalitis.

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Q

Describe the characteristics of neonatal herpes.

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Q

Describe the characteristics of Varicella-Zoster (VZV).

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Q

What is the mechanism of spread of VZV?

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Q

What is the time course of VZV?

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Q

What is the difference between chickenpox and zoster?

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Describe congenital varicella.

What are the different drugs used to treat HSV-1, HSV-2 and VZV?

What techniques can be used to make a diagnosis of HHV-1, HHV-2, or VZV?

What is a Tzanck smear?

What is the vaccine for VZV?

What are the 3 potential outcomes of Epstein-Barr Virus (EBV/HHV-4)?

Describe the pathogeneis of EBV.

What is the role of B and T cells in EBV pathogenesis?

Describe the latency of EBV.

What are the characteristics of infectious mononucleosis?

What are the characteristics cell in infectious mono?

What are the characteristics of Burkitt's Lymphoma cause by EBV?

What is the model of the evolution of Burkitt's lymphoma from EBV?

Describe the pathogenesis of Hodgkin's Lymphoma.

What are the characteristic cells of Hodgkin's lymphoma?

How does nasopharyngeal carcinoma relate to EBV?

AIDS patients infected with EBV are at risk for?

Oral Hairy Leukoplakia

What can be used to make a diagnosis of EBV.

Describe the different ways to interpret EBV antibody tests.

Describe the epidemiology of CMV?

What are the different outcomes of CMV infection?

Describe the symptoms associated with Cytomegalic Inclusion Disease.

Describe the characteristic cells in CMV.

Owl eye cells

Describe the different symptoms associated with immunosuppressed patients and CMV infection.

What is this an image of?

CMV Retinitis

How would someone test for CMV?

Describe the characteristics of HHV-6 and HHV-7.

What are the characteristics of HHV-6?

What is roseola infantum?

What are the characteristics of HHV-8?

What are these images of?

HHV-8 (KSHV) infection involving the oral cavity

Describe the pathogenesis and associated diseases associated with HHV-8.

Describe the relationship between Kaposi's Sarcoma and HHV-8.

What is classical Kaposi's Sarcoma?

What is African (endemic) Kaposi's Sarcoma?

Describe the characteristics of AIDS Kaposi's Sarcoma.

What are the latency associated proteins associated with HHV-8 infection?

Describe the progression of HHV-8 infection to Kaposi's Sarcoma or Primary Effusion lymphoma.