1.5.1 Herpesviruses Flashcards by Miles Sanderson

Q

Describe the structure and genome of HSV-1.

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Q

Describe the relationship of herpesviruses and latency.

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Q

Describe the various cell receptors for the herpesviruses.

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Q

Describe the transcription of the herpesviruses also explain the alpha, beta and gamma proteins.

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Q

Describe the Lytic Virus Life Cycle for HHV-I.

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Q

Herpesviruses are capable of forming?

A

Multinucleated giant cells - syncytia

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Q

Describe the pathogenesis of HSV-1 and HSV-2.

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Q

Describe the epidemiology of HSV-1.

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Q

Describe the latency of HSV-1 and HSV-2.

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Q

Describe the different sites of latency of the different herpesviruses.

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Q

Describe the clinical manifestations of HSV-1 (HHV-1) and HSV-2 (HHV-2).

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Q

Describe Herpes Labialis.

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Q

Who is the main culprit for genital herpes?

A

HSV-2

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Q

Describe the typical clinical course of genital herpes.

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Q

What is eczema hepeticum?

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Q

What is herpes whitlow?

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Q

What is herpes gladiatorum?

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Q

What is herpes keratoconjunctivitis?

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Q

Important: Describe the relationship of herpesvirus and encephalitis.

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Q

Describe the characteristics of neonatal herpes.

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Q

Describe the characteristics of Varicella-Zoster (VZV).

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Q

What is the mechanism of spread of VZV?

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Q

What is the time course of VZV?

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Q

What is the difference between chickenpox and zoster?

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Q

Describe congenital varicella.

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Q

What are the different drugs used to treat HSV-1, HSV-2 and VZV?

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Q

What techniques can be used to make a diagnosis of HHV-1, HHV-2, or VZV?

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Q

What is a Tzanck smear?

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Q

What is the vaccine for VZV?

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Q

What are the 3 potential outcomes of Epstein-Barr Virus (EBV/HHV-4)?

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Q

Describe the pathogeneis of EBV.

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Q

What is the role of B and T cells in EBV pathogenesis?

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Q

Describe the latency of EBV.

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Q

What are the characteristics of infectious mononucleosis?

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Q

What are the characteristics cell in infectious mono?

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Q

What are the characteristics of Burkitt’s Lymphoma cause by EBV?

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Q

What is the model of the evolution of Burkitt’s lymphoma from EBV?

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Q

Describe the pathogenesis of Hodgkin’s Lymphoma.

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Q

What are the characteristic cells of Hodgkin’s lymphoma?

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Q

How does nasopharyngeal carcinoma relate to EBV?

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Q

AIDS patients infected with EBV are at risk for?

A

Oral Hairy Leukoplakia

Q

What can be used to make a diagnosis of EBV.

A

Q

Describe the different ways to interpret EBV antibody tests.

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Q

Describe the epidemiology of CMV?

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Q

A

Q

What are the different outcomes of CMV infection?

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Q

Describe the symptoms associated with Cytomegalic Inclusion Disease.

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Q

Describe the characteristic cells in CMV.

A

Owl eye cells

Q

Describe the different symptoms associated with immunosuppressed patients and CMV infection.

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Q

What is this an image of?

A

CMV Retinitis

Q

How would someone test for CMV?

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Q

Describe the characteristics of HHV-6 and HHV-7.

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Q

What are the characteristics of HHV-6?

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Q

What is roseola infantum?

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Q

What are the characteristics of HHV-8?

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Q

What are these images of?

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HHV-8 (KSHV) infection involving the oral cavity

Q

Describe the pathogenesis and associated diseases associated with HHV-8.

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Q

Describe the relationship between Kaposi’s Sarcoma and HHV-8.

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Q

What is classical Kaposi’s Sarcoma?

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Q

What is African (endemic) Kaposi’s Sarcoma?

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Q

Describe the characteristics of AIDS Kaposi’s Sarcoma.

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Q

What are the latency associated proteins associated with HHV-8 infection?

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Q

Describe the progression of HHV-8 infection to Kaposi’s Sarcoma or Primary Effusion lymphoma.

A