1.1.4 Antiviral Chemotherapy Flashcards
What is the viral life cycle?
- Bind to and enter susceptible host cell
- Uncoating, release of viral genome
- After variable dormant period, synthesize “early” proteins (polymerases)
- Synthesis of nucleic acids
- Synthesis of “late” proteins (structural)
- Assembly of viral particles, release of virus
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/184/a_image_thumb.png?1509470489)
Class of drug of rimantadine?
Inhibitor of uncoating (anti-influenza chemotherapy)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/307/a_image_thumb.png?1509470564)
What is the MOA of rimantidine? Administration route? Side effects?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/447/a_image_thumb.png?1509470626)
What class of drug do oseltamivir and zanamivir belong to?
Viral neuraminidase inhibitors (anti-influenza chemotherapy)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/489/a_image_thumb.png?1509470732)
What is the MOA of oseltamivir? Administration route? Side effects?
Neuraminidase inhibitor - prevents viral release and subsequent infection of additional cells
*Works best if given early in the course of infection b/c it is used to limit spreading b/t cells and has little effect once the cell has been infected
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/619/a_image_thumb.png?1509470822)
What is the MOA of Zanamivir? Administration route? Contraindication?
Viral NA inhibitor - prevents release and subsequent infection of additional cells
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/861/834/a_image_thumb.png?1509470933)
What class of drug does ribavirin belong to?
Anti-metabolite - Inhibitor of viral nucleic acid synthesis
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/862/026/a_image_thumb.png?1509471058)
In which subset of patients is ribavirin contraindicated in?
Pregnant pts - ribavirin is a known teratogen and embryotoxin
How is ribavirin administered for pts with RSV? for Hep C virus?
RSV: aerosol
Hep C virus: oral
What is the MOA of ribavirin?
Anti-metabolite
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/862/689/a_image_thumb.png?1509471418)
What are the stages that can define selective toxicity?
Kinase and polymerase
What effect does dideooxynucleosides have on viral genome replication?
Chain termination
-No site to add another base on the chain
What is acyclovir?
Guanosine analogue
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/074/a_image_thumb.png?1509471804)
What is the MOA of Acyclovir? How is it activated? Administration route?
Guanosine analogue - inhibits viral genome replication
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/157/a_image_thumb.png?1509471891)
What is the mechanism of resistance found in viruses?
TK-
acyclovir doesn’t get its initial phosphorylation
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/236/a_image_thumb.png?1509471996)
What is valacyclovir?
Valine ester of acyclovir, increased biavailability because GI absorption through peptide transporter
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/372/a_image_thumb.png?1509472076)
What is ganciclovir used to treat?
Cyctomegalovirus (CMV); inhibition of viral genome replication
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/394/a_image_thumb.png?1509472160)
Administration route of ganciclovir? Initial phosphorylation?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/535/a_image_thumb.png?1509472293)
What is the difference b/t ganciclovir and acyclovir? How does this manifest itself?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/223/863/660/a_image_thumb.png?1509472352)