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Mock Exams > 2013 NC State Mock Exam Tangent Questions B > Flashcards

2013 NC State Mock Exam Tangent Questions B Flashcards

1
Q
  1. According to the Animal Welfare Act and its regulations, which of the following is TRUE regarding the membership of the IACUC?

a. The Committee shall be composed of a Chairman and at least one other additional member
b. If the Committee consists of more than three members, not more than two members shall be from the same administrative unit of the facility
c. A Doctor of Veterinary Medicine is not required to be one of the Committee members
d. At least one member shall not be affiliated in any way with the facility other than as a Committee member

A

d. At least one member shall not be affiliated in any way with the facility other than as a Committee member

Reference: Animal Welfare Act, 9 CRF Part 2 – Regulations, Subpart C – Research Facilities, §2.31 (b)(1-4) Institutional Animal Care and Use Committee (IACUC). (1-1-05 Edition, p.33)
Domain 5

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2
Q
  1. Exposure to which of the following materials has been implicated in zinc toxicosis in ferrets?

a. Acrylics
b. Copper
c. Galvanized steel
d. Polyethylene
e. Stainless steel

A

c. Galvanized steel

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 13 – Biology and Diseases of Ferrets, p. 507.
Domain 1; Secondary Species – Ferret (Mustela putorius furo)

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3
Q
  1. Which of the following is TRUE only for lentiviral vectors when compared to adenovirus and other adeno-associated viral vectors?

a. Achieve transient expression in dividing cells
b. Achieve transient expression in nondividing cells
c. Achieve stable expression in dividing cells
d. Achieve stable expression in nondividing cells

A

c. Achieve stable expression in dividing cells

Reference: Reuter et al. 2012. Assessment of hazard risk associated with the intravenous use of viral vectors in rodents. Comp Med 62(5):361-370 (Figure 1).
Domain 3

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4
Q
  1. Which of the following is FALSE regarding the use of corncob bedding for housing rats?

a. Contains minimal dust
b. Is preferred over other bedding materials by rats
c. Produces negligible levels of ammonia within the cage
d. Reduces spread of allergens

A

b. Is preferred over other bedding materials by rats

Reference: Leys et al. 2012. Rats housed on corncob bedding show less slow–wave sleep. JAALAS 51(6):764-768.
Domain 4; Primary Species – Rat (Rattus norvegicus)

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5
Q
  1. The UN 3373 label must be displayed on the outer container on two opposite sides when packaging and shipping what types of biological materials?
A

Category B infectious substance

1) http://www.ncsu.edu/ehs/dot/Bio_shipping.pdf
2) World Health Organization. 2011. Guidance on regulations for the Transport of Infectious Substances 2011-2012, p. 5. (http://www.who.int/ihr/publications/who_hse_ihr_20100801_en.pdf)
Domain 5

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6
Q
  1. Which of the following mouse strains is predisposed to developing spontaneous myocardial calcification?

a. 129
b. BALB/c
c. C57BL/6
d. FVB
e. NZB

A

b. BALB/c

1) Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell Publishing: Ames, Iowa. Chapter 1 – Mouse, p. 94.
2) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds. 2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models. Academic Press: San Diego, CA. Chapter 2 – Mouse Physiology, p. 27.
3) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 3 – Biology and Diseases of Mice, pp. 105-106.
Domain 1; Primary Species – Mouse (Mus musculus)

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7
Q
  1. Which of the following analgesics can cause gastrointestinal ulceration in rats?

a. Carprofen
b. Ketoprofen
c. Tylenol
d. Ibuprofen

A

b. Ketoprofen

1) Shientag et al. 2012. A therapeutic dose of ketoprofen causes acute gastrointestinal bleeding, erosions, and ulcers in rats. Comp Med 51(6):832-841.
2) Fish RE, Brown MJ, Danneman PJ, Karas AZ, eds. 2008. Anesthesia and Analgesia in Laboratory Animals, 2nd ed. Academic Press, San Diego, CA. Chapter 10 – Anesthesia and Analgesia for Laboratory Rodents, pp. 272-273, 277
Domain 2; Primary Species – Rat (Rattus norvegicus)

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8
Q
  1. Habituation of adult New Zealand white rabbits to routine laboratory handling by humans may result in which one of the following?

a. Behavior consistent with an increase in human-directed fear
b. Behavior consistent with a reduction in human-directed fear
c. Decreased compliance during routine laboratory handling
d. No change in behavior since adult rabbits cannot be habituated to handling by humans

A

b. Behavior consistent with a reduction in human-directed fear

1) Swennes et al. 2011. Human handling promotes compliant behavior in adult laboratory rabbits. JAALAS 50(1):41-45
2) National Research Council. 2011. Guide for the Care and Use of Laboratory Animals, 8th ed. National Academies Press, Washington D.C. Chapter 3 – Environment, Housing, and Management, pp. 64-65.
Domain 3; Primary Species – Rabbits (Oryctolagus cuniculus)

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9
Q
  1. With a water temperature of 28.5oC, how many minutes after fertilization does it take for the first embryo cleavage in zebrafish to occur?
A

**45 **

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 19 – Biology and Diseases of Zebrafish, p. 863.
Domain 4; Secondary Species – Zebrafish (Danio rerio)

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10
Q
  1. According to the 2007 AVMA Guidelines on Euthanasia, which of the following agents or methods is a conditionally acceptable method of euthanasia for fish?

a. Carbon dioxide
b. Barbiturates
c. Benzocaine hydrochloride
d. Decapitation and pithing
e. Inhalant anesthetics

A

d. Decapitation and pithing

1) American Veterinary Medical Association. 2007. AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia), pp. 20, 28,
(http://www.avma.org/issues/animal_welfare/euthanasia.pdf).
2) Fish RE, Brown MJ, Danneman PJ, Karas AZ, eds. 2008. Anesthesia and Analgesia in Laboratory Animals, 2nd ed. Academic Press, San Diego, CA. 21 – Anesthesia and Restraint of Laboratory Fish, pp.532-533.
Domain 5; Secondary Species – Zebrafish (Danio rerio) and Tertiary Species – Other Fish

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11
Q
  1. All of the following statements are true about splay leg in rabbits EXCEPT?

a. Affected rabbits cannot abduct their limbs
b. Animals are most commonly affected in the right rear limb
c. Young kits 3 to 4 weeks of age are most commonly affected
d. The semimembranosus muscle is abnormal, with smaller fibers and abnormal mitochondria
e. Typical clinical signs are secondary to femoral endotorsion

A

a. Affected rabbits cannot abduct their limbs

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002 Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 9 – Biology and Diseases of Rabbits, pp. 354-355.
2) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press: San Diego, CA. Chapter 17 – Mycoses and Non-Infectious Diseases, pp. 511-512.
Domain 1; Primary Species – Rabbit (Oryctolagus cuniculus)

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12
Q
  1. Which of the following cell types form the lateral line in fish and amphibians?

a. Neuromast
b. Fibroblast
c. Chondrocytes
d. Endothemast
e. Astrocytes

A

a. **Neuromast **

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 17 – Biology and Diseases of Amphibians, p. 802.
Domain 3; Tertiary Species – Other Amphibians and Other Fish

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13
Q
  1. Which one of the following DOES NOT apply to a Foreign Assurance required for institutions outside the U.S. that receive PHS funds directly through a grant or contract award or that receive PHS funds indirectly (named as a performance site by a primary awardee institution)?

a. Before submitting a grant application to NIH for the first time, a foreign institution must apply for an OLAW-approved animal welfare assurance
b. OLAW will contact the awardee institution to negotiate whether a Foreign Assurance is required
c. The funding component or Institute in NIH will notify OLAW that an Assurance is required for the pending award
d. Foreign institutions should not submit an Assurance unless requested to do so by OLAW
e. Foreign Assurances are renewed only if the institution has current PHS funding

A

a. Before submitting a grant application to NIH for the first time, a foreign institution must apply for an OLAW-approved animal welfare assurance

References:1) Office of Laboratory Animal Welfare, Obtaining an Assurance. http://grants.nih.gov/grants/olaw/obtain_assurance.htm
2) National Institutes of Health (NIH), Change In Criteria For Renewal of Animal Welfare Assurances For Foreign Institutions. Notice Number: NOT-OD-12-081, Release Date: March 8, 2012.
Domain 5

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14
Q
  1. What is the most frequently occurring tumor in most rat stocks and strains?
A

Mammary fibroadenoma

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 4 – Biology and Diseases of Rats, pp. 154-156.
2) Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell Publishing: Ames, Iowa. Chapter 2 – Rat, pp. 169-176.
3) Suckow MA, Weisbroth SH, Franklin CL, eds. 2006. The Laboratory Rat, 2nd edition. Elsevier Academic Press: San Diego, CA. Chapter 14 – Neoplastic Disease, pp. 501-502.
Domain 1; Primary Species – Rat (Rattus norvegicus)

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15
Q
  1. Neuroleptanalgesia refers to a combination of what two types of drugs?
A

Opioid analgesic and tranquilizer

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 22 – Preanesthesia, Anesthesia, Analgesia, and Euthanasia, pp. 957-958.
2) Fish RE, Brown MJ, Danneman PJ, Karas AZ, eds. 2008. Anesthesia and Analgesia in Laboratory Animals, 2nd ed. Academic Press, San Diego, CA. Chapter 2 – Pharmacology of Injectable Anesthetics, Sedatives, and Tranquilizers, pp. 64-65.
Domain 2

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16
Q
  1. Which of the following rat strains is an animal model for Type 1 diabetes?

a. Zucker
b. BN
c. Dahl
d. BBDP

A

d. BBDP

1) Grant et al. 2012. Development of standardized insulin treatment protocols for spontaneous rodent models of type 1 diabetes. Comp Med 62(5):381-390.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 4 – Biology and Diseases of Rats, pp. 122, 152.
3) Suckow MA, Weisbroth SH, Franklin CL, eds. 2006. The Laboratory Rat, 2nd edition. Elsevier Academic Press: San Diego, CA. Chapter 23 – Spontaneous, Surgically and Chemically Induced Models of Disease, pp. 714-717.
Domain 3; Primary Species – Rat (Rattus norvegicus)

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17
Q
  1. Which of the following is a common husbandry and management consideration when working with cotton rats?

a. May spin when picked up by tail and have tail slip
b. Specialized nutritional requirements
c. Eusocial behavior
d. Requirement for large, reinforced plastic cages instead of standard caging

A

a. May spin when picked up by tail and have tail slip

1) Ayers et al. 2012. Alternatives to retroorbital blood collection in hispid cotton rats (Sigmodon hispidus). JAALAS 51(2):239-245
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 7 - Biology and Diseases of Other Rodents, pp. 270- 271.
Domain 4; Tertiary Species - Other Rodents

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18
Q
  1. Individual animals experiencing pain or distress, which is alleviated with anesthetics, analgesics, sedatives and/or tranquilizers should be reported in which column(s) of the annual report to the USDA (APHIS Form 7023)?
A

column D

Reference: USDA Animal and Plant Health Inspection Service Animal Care Policy Manual. Policy # 11 – Painful / Distressful Procedures. April 14, 1997
(http://www.aphis.usda.gov/animal_welfare/downloads/policy/policy11.pdf
Domain 5

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19
Q
  1. What is the only hamster species reported to develop atypical fibrosarcoma?
A

Phodopus sungorus

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 5 - Biology and Diseases of Hamsters, pp. 186-187, 193, 195-197.
2) Kondo et al. 2011. Atypical fibrosarcomas derived from cutaneous ganglion cell-like cells in 2 domestic Djungarian hamsters (Phodopus sungorus). JAALAS 50(4):523-525.
3) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press: San Diego, CA. Chapter 33 – Non-Infectious Diseases, p. 872; Chapter 35 – The Chinese or Striped-Back Hamster, pp. 911-912; Chapter 36 – The European Hamster, p. 929; Chapter 37 – Other Hamsters, pp. 937-938
Domain 1; Tertiary Species – Other Rodents

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20
Q
  1. Which rat strain is a spontaneous model for hypertension?
A

SHR

1) Azar et al. 2012. Effects of Cage Enrichment on Heart Rate, Blood Pressure, and Activity of Female Sprague-Dawley and Spontaneously Hypertensive Rats at Rest and after Acute Challenges. JAALAS 51(3):339-344
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 3 – Biology and Disease of Rats, p.122
3) Suckow MA, Weisbroth SH, Franklin CL, eds. 2006. The Laboratory Rat, 2nd edition. Elsevier Academic Press: San Diego, CA. Chapter 26 – Cardiovascular Research, pp. 783-785.
Domain 3; Primary Species – Rat (Rattus norvegicus)

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21
Q
  1. What is the gestation period of Mesocricetus auratus?
A

15-18 days

1) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press: San Diego, CA. Chapter 56 – Normative Values, p. 1234.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 5 – Biology and Diseases of Hamsters, p. 175.
Domain 4; Secondary Species – Syrian Hamster (Mesocricetus auratus)

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22
Q
  1. Which of the following guidelines concerning the use of non-pharmaceutical-grade chemicals in studies conducted with experimental animals IS NOT described in the most current version of the Guide for the Care and Use of Laboratory Animals?

a. Non-pharmaceutical-grade chemicals should only be used when pharmaceutical-grade chemicals are not available
b. Use of non-pharmaceutical-grade chemicals should be described and justified in the IACUC-approved protocol
c. If non-pharmaceutical-grade chemicals are used, consideration should be given to such things as the grade, purity, sterility, pH, pyrogenicity, osmolality and compatibility of the chemical
d. If a non-pharmaceutical-grade chemical is to be used, consideration should be given to animal welfare and scientific issues relating to its use
e. There are no restrictions on the use of non-pharmaceutical-grade chemicals

A

e. There are no restrictions on the use of non-pharmaceutical-grade chemicals

Reference: Institute for Laboratory Animal Research, Division on Earth and Life Studies, The National Research Council. 2011. Guide for the Care and Use of Laboratory Animals. The National Academies Press: Washington, D.C. Chapter 2 – Animal Care and Use Program, p. 31.
Domain 5

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23
Q
  1. In addition to obesity, glucose intolerance, and insulin resistance, which of the following are also considered components of metabolic syndrome in pigs?

a. Hypertension, dyslipidemia
b. Hyperglycemia, anemia
c. Leukocytosis, hypertriglyceridemia
d. >10% weight loss, elevated high density lipoproteins
e. Decreased low density lipoproteins, >10% weight gain

A

a. Hypertension, dyslipidemia

Reference: Neeb et al. 2010. Metabolic syndrome and coronary artery disease in Ossabaw compared with Yucatan swine. Comp Med 60(4):300-315.
Domain 1; Primary Species – Pig (Sus scrofa)

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24
Q
  1. According to the 2007 AVMA Guidelines on Euthanasia, which of the following is TRUE regarding the use of cervical dislocation as a method of euthanasia?

a. Conditionally acceptable for rats weighing less than 0.25 kg
b. Acceptable for small birds
c. Rabbits
d. Mode of action is direct depression of brain

A

d. Mode of action is direct depression of brain

Reference: American Veterinary Medical Association. 2007. AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia), pp. 14, 28-29, 32 (http://www.avma.org/issues/animal_welfare/euthanasia.pdf).
Domain 2

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25
Q
  1. Which one of the following is a potential adverse event resulting from administration of Complete Freund’s Adjuvant?

a. Blindness
b. Granulomas
c. Immunosuppression
d. Impotency
e. Respiratory distress

A

b. Granulomas

1) ARAC. 2010. Guidelines for the Use of Adjuvants in Research. NIH Intramural Guidelines. (http://www.fcf.usp.br/Apresentacao/Colegiados/CEUA/Legislacao/uso%20de%20adjuvantes.pdf)
2) Halliday et al. 2004. Effects of Freund’s complete adjuvant on the physiology, histology, and activity of New Zealand white rabbits. JAALAS 43(1):8-13
3) Hill et al. 2006. Posterior paresis and osteolysis in guinea pigs (Cavia porcellus) secondary to Freund’s adjuvant immunization. JAALAS 45(2):53-56
Domain 3

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26
Q
  1. Which diet has the ingredients listed but the quantitative ingredient formulation is not publicly available?
A

Closed-formula diet

1) Barnard et al. 2009. Open- and closed-formula laboratory animal diets and their importance to research. JAALAS 48(6):709-713.
2) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds. 2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models. Academic Press: San Diego, CA. Chapter 10 - Nutrition, pp. 351-353.
3) Suckow MA, Weisbroth SH, Franklin CL, eds. 2006. The Laboratory Rat, 2nd edition. Elsevier Academic Press: San Diego, CA. Chapter 9 – Nutrition, pp.269-271.
Domain 4

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27
Q
  1. Which of the following species would be regulated by the United States Department of Agriculture?

a. Meleagris gallopava as a model of dilated cardiomyopathy
b. Aplysia californica to in a behavior study for memory learning
c. Equis caballus to teach an undergraduate class handling techniques
d. Suncus murinus to test the efficacy of novel antiemetics
e. Capra hircus to study the feed efficiency of a new maintenance diet

A

d. Suncus murinus to test the efficacy of novel antiemetics

1) Animal Welfare Act, 9 CFR Part 1 – Definition of Terms, §1.1 Definitions (1-1-00 Edition, p. 7)
2) Animal Care. January 2002. APHIS Fact Sheet: The Animal Welfare Act. (http://www.ca-biomed.org/pdf/media-kit/oversight/USDAAWA.pdf)
3) Animal Care. July 2005. APHIS Fact Sheet: The Animal Care Program and the U.S. Department of Agriculture’s Authority Under the Animal Welfare Act: Basic Questions and Answers
(http://www.aphis.usda.gov/publications/animal_welfare/content/printable_version/faq_awa.pdf)
Domain 5; Tertiary Species - Other Rodents

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28
Q
  1. Which of the following work experiences WOULD NOT count towards eligibility for AALAS certification?

a. Cagewash operations
b. Clinical pathology laboratory duties
c. Driving delivery vehicles
d. Procurement of laboratory animals
e. Quality assurance functions that relate to laboratory animal science

A

c. Driving delivery vehicles

http://www.aalas.org/pdf/Tech_Cert_handbook.pdf (p. 3)
Domain 6

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29
Q
  1. Which etiologic agent is the cause of guinea pig inclusion conjunctivitis?
A

Chlamydophilia caviae

1) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press: San Diego, CA. Chapter 23 – Infectious Diseases, pp. 638-641, 650-654 , 667-668
2) Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell Publishing: Ames, Iowa. Chapter 4 - Guinea Pig, pp. 221-222, 226-229, 236-237.
3) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 6 - Biology and Diseases of Guinea Pigs, pp. 212-213, 220-222, 224-225.
Domain 1; Secondary Species – Guinea Pig (Cavia Porcellus)

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30
Q
  1. Marmota monax is a research model for which of the following human conditions?

a. Human hepatitis A virus
b. Human hepatitis B virus
c. Human hepatitis C virus
d. Gall stones
e. Periodontal disease

A

b. Human hepatitis B virus

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 7 – Biology and Diseases of other Rodents, pp. 254-255, 268; Chapter 8 – Woodchucks as Laboratory Animals, pp. 310, 321-322
Domain 3; Tertiary Species – Other Rodents

31
Q
  1. What is the hearing range of the mouse?
A

1 to 100 kHz

1) Reynolds et al. 2010. Noise in a laboratory animal facility from the human and mouse perspectives. JAALAS 49(5):592-597.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 29 – Factors That May Influence Research, p. 1150
Domain 4; Primary Species – Mouse (Mus musculus)

32
Q
  1. The Animal Welfare Act gives the Secretary of Agriculture the authority to establish rules, regulations, or orders regarding all of the following EXCEPT?

a. Animal care
b. Animal housing
c. Animal transportation standards
d. Design or performance of research protocols involving animals

A

d. Design or performance of research protocols involving animals

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, p. 20.
Domain 5

33
Q
  1. In the nitrogen or nitrification cycle within the biofilter of a zebrafish housing system, ________ converts ammonia into nitrite and ________ converts nitrite to nitrate.
A

Nitrosomonas, Nitrobacter

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 19 – Biology and Management of Zebrafish, p. 869
2) Koerber and Kalishman. 2009. Preparing for a semiannual IACUC inspection of a satellite zebrafish (Danio rerio) facility. JAALAS 48(1):65–75.
Domain 4; Secondary Species – Zebrafish (Danio rerio)

34
Q
  1. What does the Richmond Agitation-Sedation scale subjectively assess?
A

Level of consciousness

Reference: Leyden and Hanneman. 2012. Validity of the modified Richmond agitation-sedation scale for use in sedated, mechanically ventilated Swine. JAALAS 51(1):63-68.
Domain 2

35
Q
  1. Which of the following species are used to study prion diseases because of their susceptibility to scrapie, transmissible mink encephalopathy and Gestmann-Staussler syndrome?

a. Cavia porcellus
b. Meriones unguiculatus
c. Mesocricetus auratus
d. Mystromys albicaudatus
e. Octogon degu

A

c. Mesocricetus auratus

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 5 – Biology and Diseases of Hamsters, p. 170; Chapter 6 – Biology and Diseases of Guinea Pigs, p. 204; Chapter 7 – Biology and
Diseases of Other Rodents, pp. 273, 275-276, 284
2) Suckow MA, Stevens KA, Wilson RP, eds. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. Academic Press: San Diego, CA. Chapter 34 – The Experimental Use of Syrian Hamsters, p. 894.
Domain 3; Secondary Species – Syrian Hamster (Mesocricetus auratus)

36
Q
  1. Which of the following species must be housed in a separate room from Saimiri sciureus which may be latently infected with Herpesvirus saimiri?

a. Aotus trivirgatus
b. Callithrix jacchus
c. Macaca fascicularis
d. Pan troglodytes

A

a. Aotus trivirgatus

Reference: Institute for Laboratory Animal Research. 2011. Guide for the Care and Use of Laboratory Animals Academies Press: Washington, D.C. Chapter 4 – Veterinary Care, p. 112.
Domain 4; Secondary Species – Squirrel Monkey (Saimiri sciureus) and Tertiary Species – Other Nonhuman Primates

37
Q
  1. According to the Animal Welfare Act and its regulations, is flooding of prairie dog towns an acceptable capture method of prairie dogs?
A

Not acceptable

1) USDA Animal and Plant Health Inspection Service Animal Care Policy Manual. Policy # 19: Capture Methods of Prairie Dogs March 25, 2011.
(http://www.aphis.usda.gov/animal_welfare/policy.php?policy=19)
2) Animal Welfare Act, 9 CFR Part 2 – Regulations, Subpart C – Research Facilities, §2.131(a)(1) Handling of animals and §2.126 Access and inspection of records and property (1-1-01 Edition, pp. 39-40)
Domain 5

38
Q
  1. Which of the following statements is TRUE regarding simian beta retrovirus (formerly simian type D retrovirus) infections in macaques?

a. Naturally found in Asian macaques; causes immunosuppressive disease; often results in anemia and neutropenia
b. Naturally found in squirrel monkeys; causes lymphoproliferative disease; often results in neoplasia
c. Naturally found in owl monkeys; causes immunosuppressive disease; often results in anemia and lymphopenia
d. Naturally found in baboons; can result in immunosuppressive disease; is generally asymptomatic

A

a. Naturally found in Asian macaques; causes immunosuppressive disease; often results in anemia and neutropenia

1) Montiel et al. 2012. Effects of simian betaretrovirus serotype 1 (SRV1) infection on the differentiation of hematopoietic progenitor cells (CD34+) derived from bone marrow of rhesus macaques (Macaca mulatta) . Comp Med 62(1):61-68
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 – Nonhuman Primates, pp. 753-756
Domain 1; Primary Species – Macaques (Macaca spp.)

39
Q
  1. In which of the following species did the estrogen receptor antagonist tamoxifen delay but not abolish labor?
A

Rat

Reference: Narver. 2012. Oxytocin in the treatment of dystocia in mice. JAALAS 51(1):10-17
Domain 3; Primary Species – Rat (Rattus norvegicus)

40
Q
  1. What is the maximum recommended storage temperature for natural ingredient feed?
A

21°C (70°F)

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002 Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 21 – Design and Management of Animal Facilities, p. 916.
2) Institute for Laboratory Animal Resources. 2011. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C. Chapter 3 – Environment, Housing and Management, p. 66.
Domain 4

41
Q
  1. According to the most current version of the Guide for the Care and Use of Laboratory Animals, which one of the following is an important guideline concerning restraint of animals?

a. Restraint devices should be considered a normal method of housing
b. Restraint devices should be used simply as a convenience in handling and managing animals
c. Alternatives to physical restraint do not need to be considered
d. Animals that fail to adapt to restraint devices should be removed from the study
e. Training of animals to adapt to restraint equipment should be done with negative reinforcement

A

d. Animals that fail to adapt to restraint devices should be removed from the study

Reference: Institute for Laboratory Animal Research, Division on Earth and Life Studies, The National Research Council. 2011. Guide for the Care and Use of Laboratory Animals. The National Academies Press: Washington, D.C. Chapter 2 – Animal Care and Use Program, p. 29.
Domain 5

42
Q
  1. Which breed of dogs are more predisposed to parvoviral enteritis and should be vaccinated every 3 weeks from 6-18 weeks old?
A

Rottweilers

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 11 – Biology and Disease of Dogs, p. 413.
Domain 1; Primary Species – Dog (Canis familiaris)

43
Q
  1. Which of the following inhalant anesthetics is a respiratory irritant and causes increased respiratory secretion in rodents?

a. Ether
b. Halothane
c. Isoflurane
d. Methoxyflurane
e. Sevoflurane

A

a. Ether

1) Fish RE, Brown MJ, Danneman PJ, Karas AZ, eds. 2008. Anesthesia and Analgesia in Laboratory Animals, 2nd ed. Academic Press, San Diego, CA. Chapter 10 – Anesthesia and Analgesia for Laboratory Rodents, pp. 252-255, 266.
2) American Veterinary Medical Association. 2007. AVMA Guidelines on Euthanasia (Formerly Report of the AVMA Panel on Euthanasia), pp. 6-7 (http://www.avma.org/issues/animal_welfare/euthanasia.pdf).
Domain 2

44
Q
  1. Rapid infusion or administration of excessive volume by which of the following administration routes can potentially lead to aspiration pneumonia and suffocation?

a. Intravenous
b. Intranasal
c. Oral gavage
d. Intramuscular
e. Intrathecal

A

b. Intranasal

1) Turner et al. 2011. Administration of substances to laboratory animals: routes of administration and factors to consider. JAALAS 50(5):600-613.
2) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds. 2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models. Academic Press: San Diego, CA. Chapter 13 - Biomethodology and Surgical Techniques, pp. 445-452.
Domain 3

45
Q
  1. Which of the following nonhuman primate species is capable of breeding continuously throughout the year?

a. Cynomolgus macaques
b. Rhesus macaques
c. Sooty mangabeys
d. Squirrel monkeys

A

a. Cynomolgus macaques

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 – Nonhuman Primates, pp. 695, 699, 704.
2) http://pin.primate.wisc.edu/factsheets/entry/sooty_mangabey/behav
Domain 4; Primary Species – Macaques (Macaca spp.)

46
Q
  1. According to Good Laboratory Practice for conducting nonclinical laboratory studies, who is responsible for inspections of the testing facility?

a. An authorized employee or duly designated representative of Environmental Protection Agency or Food and Drug Administration
b. An authorized employee of the Food and Drug Administration.
c. An authorized employee of the United Stated Department of Agriculture
d. An authorized employee of the organization’s Quality Assurance Unit
e. Study director and attending veterinarian at least once a year

A

b. An authorized employee of the Food and Drug Administration

Reference: 21CFR PART 58—Good Laboratory Practice for Nonclinical Laboratory Studies, Subpart A - General Provisions, § 58.15 Inspection of a testing facility. (4–1–10 Edition, pp. 308-309).
Domain 5

47
Q
  1. Which organization was founded in 1967 to promote dissemination of knowledge regarding laboratory animal medicine, to foster research, to serve as a spokesman for veterinarians in laboratory animal practice, and to encourage continuing education in the field?
A

d. ASLAP

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 1 – Historical Perspectives, pp.13-15.
2) www.aslap.org
Domain 6

48
Q
  1. A weanling rabbit has diarrhea and dehydration. At necropsy, the ileum and jejunum are grossly thickened and corrugated in appearance. On histology, a silver stain of the intestinal mucosa reveals clusters of organisms within the apical cytoplasm of the enterocytes. What is the most likely diagnosis?
A

Lawsonia intracellularis

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 9 – Biology and Diseases of Rabbits, pp. 342-344, 347.
2) Percy DH and Barthold SW. 2007. Pathology of Laboratory Rodents and Rabbits, 3rd ed. Blackwell Publishing: Ames, Iowa. Chapter 6 - Rabbit, pp. 268-276, 294.
Domain 1; Primary Species – Rabbit (Oryctolagus cuniculus)

49
Q
  1. All of the following are criteria for gene symbols EXCEPT?

a. Be short, normally 3-5 characters, not > 10 characters
b. Use only Arabic letters and Roman numbers
c. Begin with an uppercase letter (not a number), followed by all lowercase letters/numbers
d. Not include tissue specificity or molecular weight designations

A

b. Use only Arabic letters and Roman numbers

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 3 – Biology and Diseases of Mice, p. 39.
2) International Committee on Standardized Genetic Nomenclature for Mice and Rat Genome and Nomenclature Committee. Guidelines for Nomenclature of Genes, Genetic Markers, Alleles, and Mutations in Mouse and Rat. September 2011.
http://www.informatics.jax.org/mgihome/nomen/gene.shtml
Domain 3

50
Q
  1. Which of the following statements is TRUE regarding the thermoneutral zone (TNZ) of an animal?

a. Ambient temperature must fall within the TNZ of the species housed in order to be within regulatory compliance
b. Temperatures outside of the TNZ result in physiological and behavioral changes to maintain homeostasis
c. Temperatures below the TNZ result in reduced basal metabolic rate due to reduced energy expenditure
d. TNZ of mice ranges between 200C and 260C

A

b. Temperatures outside of the TNZ result in physiologic and behavioral changes to maintain homeostasis.

1) National Research Council. 2011. Guide for the Care and Use of Laboratory Animals, 8th ed. National Academies Press, Washington D.C. Chapter 3 - Environment, Housing and Management, p. 43.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 29 – Factors that may Influence Animal Research, pp. 1147-1148.
Domain 4

51
Q
  1. Which agency administers the Animal Welfare Act and its regulations?
A

Animal and Plant Health Inspection Service

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, p. 21.
Domain 5

52
Q
  1. Which of the following parasites is the most likely cause of palpable abdominal masses in a tamarin with diarrhea and weight loss?

a. Anatrichosoma cynomolgi
b. Prosthenorchus elegans
c. Strongyloides cebus
d. Trichospirura leptosoma

A

b. Prosthenorchus elegans

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 – Nonhuman Primates, pp. 762, 765-766.
2) Baker DG, ed. 2007. Flynn’s Parasites of Laboratory Animals, 2nd edition. Blackwell Publishing, Iowa, USA. Chapter 21 - Parasites of Non-human Primates, pp. 707—709, 715-716.
Domain 1; Secondary Species – Marmoset/Tamarins (Callitrichidae)

53
Q
  1. A disease that occurs naturally in nonhuman species but has not been described in humans is an example of what type of animal model?
A

Orphan

1) Casals et al. 2011. The use of animal models for stroke research: a review. Comp Med 61(4):305-313
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 30 - Animal Models in Biomedical Research, p. 1187
Domain 3

54
Q
  1. Which of the following viruses is the least sensitive to disinfectants?

a. Mouse hepatitis virus
b. Pneumonia virus of mice
c. Sialodacryoadenitis virus
d. Sendai
e. Theiler’s murine encephalomyelitis virus

A

e. TMEV

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 10 – Microbiological Quality Control for Laboratory Rodents and Lagomorphs, p. 371 (Table IV).
Domain 4

55
Q
  1. According to the most recent version of the Guide for the Care and Use of Laboratory Animals, what type of monitoring should be done to ensure that an animal’s nutritional needs are met when food or fluids are regulated or restricted as part of a study?
A

** Body weights should be recorded at least weekly**

Reference: Institute for Laboratory Animal Resources. 2011. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C. Chapter 2 – Animal Care and Use Program, p. 31.
Domain 5

56
Q
  1. What best describes the Whitten effect in mice?
A

Synchronization of the female mouse estrus cycle after introduction of a male mouse or his odor

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 3 - Biology and Diseases of Mice, p. 50.
2) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds. 2007. The Mouse in Biomedical Research, 2nd edition, Volume 1 – History, Wild Mice, and Genetics. Academic Press: San Diego, CA. Chapter 4 – Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background and Strain Types p. 54.
Domain 4; Primary Species - Mouse (Mus musculus)

57
Q
  1. Which of the following statements best describes the etiology and epizootiology of pseudorabies?

a. Arenavirus; carried subclinically by cats and dogs; primarily affects respiratory and nervous system of pigs
b. Arenavirus; common zoonotic pathogen of importance in humans; primarily affects gastrointestinal and nervous system of pigs
c. Herpesvirus; results in death when it infects cats and dogs; primarily affects respiratory and nervous system of pigs
d. Herpesvirus; carried subclinically by other farm animals including ruminants; primarily affects gastrointestinal system and nervous system of pigs

A

c. Herpesvirus; results in death when it infects cats and dogs; primarily affects respiratory and nervous system of pigs

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press, San Diego, CA. Chapter 15 – Biology and Diseases of Swine, pp. 634-635.
2) http://www.aphis.usda.gov/animal_health/animal_dis_spec/swine/f_a_q.shtml
Domain 1; Primary Species – Pig (Sus scrofa)

58
Q
  1. Gadolinium contrast enhanced MRI has been used mainly for the visualization of what type of tissue?

a. Fibrotic
b. Myocardial
c. Necrotic
c. Neural
d. Proliferative

A

c. Necrotic

Reference: Hu et al. 2012. Magnetic resonance imaging (MRI) assessment of ventricular remodeling after myocardial infarction in rabbits. Comp Med. 62(2):116-123.
Domain 3

59
Q
  1. Which of the following disinfectants is classified as denaturant?

a. Chlorine dioxide
b. Ethanol
c. Glutaraldehyde
d. Hydrogen peroxide
e. Povidone-iodine

A

b. Ethanol

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 10 - Microbiological Quality Control for Laboratory Rodents and Lagomorphs, p. 370.
2) Institute for Laboratory Animal Resources. 2011. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C. Chapter 4 – Veterinary Care, p. 119.
3) Keen et al. 2010. Efficacy of soaking in 70% isopropyl alcohol on aerobic bacterial decontamination of surgical instruments and gloves for serial mouse laparotomies. JAALAS 49(6):832-837.
4) Huerkamp. 2001. Alcohol as a disinfectant for aseptic surgery of rodents: crossing the thin blue line? Contemp Top Lab Anim Sci 41(1):11-12.
Domain 4

60
Q
  1. According to the Animal Welfare Act and its regulations, who is responsible for ensuring investigators have avoided or minimized discomfort, distress, or pain to the animals?
A

Institutional animal care and use committee

1) USDA Animal and Plant Health Inspection Service Animal Care Policy Manual. Policy # 11: Painful and Distressful Procedures. March 25, 2011
(http://www.aphis.usda.gov/animal_welfare/policy.php?policy=11).
2) Animal Welfare Act, 9 CFR, Part 2 - Regulations, Subpart C - Research Facilities, §2.31 (d)(i, ii, iv) and (e)(4)Institutional Animal Care and Use Committee; §2.33(b)(4) Attending veterinarian and adequate veterinary care (11-01-05 Edition)
Domain 5

61
Q
  1. Which of the following statements best describes Macacine herpesvirus 1?

a. Alphaherpesvirus that causes persistent, subclinical latent infection in the natural host species, macaques
b. Betaherpesvirus that occurs in humans and nonhuman primate species that rarely causes overt disease
c. Betaherpesvirus that causes persistent, subclinical latent infection in the natural host species; macaques
d. Gammaherpesvirus that causes persistent, subclinical latent infection in the natural host species; macaques

A

a. Alphaherpesvirus that causes persistent, subclinical latent infection in the natural host species; macaques

1) Katz et al. 2012. Reassessing the detection of B-virus-specific serum antibodies. Comp Med 62(6):516-526
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 – Nonhuman Primates pp. 746-749.
Domain 1; Primary Species - Macaques (Macaca spp.)

62
Q
  1. According to the Animal Welfare Act and its regulations, under what circumstances can pain and/or distress relieve care be withheld?
A

Withholding of pain and/or distress relieving care must be scientifically justified in writing and approved by the IACUC

1) USDA Animal and Plant Health Inspection Service Animal Care Policy Manual. Policy # 3: Veterinary Care, March 25, 2011
(http://www.aphis.usda.gov/animal_welfare/downloads/policy/Policy%20Manual%2003-25-2011.pdf)
2) Animal Welfare Act, 9 CFR Part 2 – Regulations, Subpart C – Research Facilities, §2.31(d)(iv)(A)(B) Institutional Animal Care and Use Committee (IACUC) (1-1-01 Edition, p. 22).
Domain 2

63
Q
  1. Which of the following parasites has been used as a minimally invasive method to sample blood from rabbits?

a. Cheyletiella parasitovorax
b. Culicoides brevitarsis
c. Ctenocephalides felis
d. Dipetalogaster maximus
e. Listrophorus gibbus

A

d. **Dipetalogaster maximus **

Reference: Markvardsen et al. 2012. Less invasive blood sampling in the animal laboratory: clinical chemistry and haematology of blood obtained by the Triatominae bug Dipetalogaster maximus. Laboratory Animals 46(2):136-141.
Domain 3; Primary Species – Rabbit (Oryctolagus cuniculus)

64
Q
  1. Newly imported nonhuman primates must be quarantined for a minimum of how many days at a CDC-registered primate import facility?
A

31 days

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 16 - Nonhuman primates, p. 724.
2) Roberts and Andrews. 2008. Nonhuman primate quarantine: its evolution and practice. ILAR J 49(2):145-156.
3) 42 CFR, Part 71 – Foreign Quarantine, Subpart F – Importations, §71.53 Nonhuman Primates. (10-1-03 Edition, p. 433)
4) http://www.cdc.gov/animalimportation/lawsregulations/nonhuman-primates/nprm/questions-answers-importers.html
Domain 4

65
Q
  1. Which organization enforces CITES?
A

United States Fish and Wildlife Service

1) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press, San Diego, CA. Chapter 2 – Laws, Regulations, and Policies Affecting the Use of Laboratory Animals, p. 30
2) http://www.cites.org/common/disc/sec/CITES-USFWS.pdf
Domain 5

66
Q
  1. All of the following certifications are administered by AALAS EXCEPT?

a. ALAT
b. CMAR
c. CPIA
d. LAT
e. LATG

A

c. CPIA

1) http://www.aalas.org/certification/tech_cert.aspx
2) http://www.aalas.org/certification/cmar.aspx
3) http://www.primr.org/certification.aspx?id=230
Domain 6

67
Q
  1. Which of the following is one of the most consistent histological findings of polytetrafluoroethylene toxicosis in chickens?

a. Centrilobular hepatic necrosis
b. Renal tubular necrosis
c. Pulmonary hemorrhage
d. Proventricular dilatation
e. Neuronal necrosis in the cerebrum

A

c. Pulmonary hemorrhage

Reference: Shuster et al. 2012. Polytetrafluoroethylene toxicosis in recently hatched chickens (Gallus domesticus). Comp Med 62(1):49-52.
Domain 1; Tertiary Species – Chicken (Gallus domesticus)

68
Q
  1. The compound 4-vinlycyclohexene diepoxide is used in research to induce what physiological or disease processes in mammals?
A

Regression of primordial and primary ovarian follicles

1) Appt et al. 2010. Experimental induction of reduced ovarian reserve in a nonhuman primate model (Macaca fascicularis). Comp Med 60(5):380-388
2) Muhammad et al. 2009. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med 59(1):46-59
Domain 3

69
Q
  1. Because most magnetic resonance (MR) scanners require the use of cryogens, rooms with MR scanners must be equipped with which of the following items?

a. Carbon dioxide sensors
b. Fire extinguishers
c. Nitrogen sensors
d. Oxygen sensors
e. Superconducting gloves

A

d. **Oxygen sensors **

1) Institute for Laboratory Animal Resources. 2011. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, D.C. Chapter 5 – Physical Plant, pp. 146-147.
2) Klaunberg and Davis. 2008. Considerations for laboratory animal imaging center design and setup. ILAR J 49(1): 4-16.
Domain 4

70
Q
  1. According to the most current version of the Guide for the Care and Use of Laboratory Animals, what is the minimum height requirement for a primary enclosure housing a rabbit in a research facility?
A

** 16 inches**

Reference: National Research Council. 2011. Guide for the Care and Use of Laboratory Animals, 8th ed. National Academies Press, Washington D.C. Chapter 3 - Environment, Housing, and Management. p. 59
Domain 5; Primary Species – Rabbit (Oryctolagus cuniculus)

71
Q
  1. Which of the following viruses is the most resistant to inactivation by disinfectants?

a. Mouse parvovirus
b. Sialodacryoadenitis virus
c. Sendai virus
d. Mouse hepatitis virus

A

a. Mouse parvovirus

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 10 – Microbial Quality Control for Laboratory Rodents and Lagomorphs, p. 371.
Domain 4

72
Q
  1. What is the mechanism of action of the drug naltrexone?
A

Nonselective opioid receptor antagonist

Reference: Kempf et al. 2012. Effects of extended release injectable naltrexone on self-injurious behavior in Rhesus macaques (Macaca mulatta). Comp Med 62(3):209-217.
Domain 2

73
Q
  1. What does the acronym SPÈCT stand for?
A

**Single Photon Emission Computed Tomography **

1) Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL, eds. 2007. The Mouse in Biomedical Research, 2nd edition, Volume 3 – Normative Biology, Husbandry, and Models. Academic Press: San Diego, CA. Chapter 9 – Design and Management of Research Facilities for Mice, p. 282.
2) Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 23 – Techniques of Experimentation, p. 1033.
Domain 3

74
Q
  1. What are the three types of filtration that are commonly used in the management of aquatic housing systems?
A

Mechanical, biological, and chemical

Reference: Fox JG, Anderson LC, Loew FM, Quimby FW, eds. 2002. Laboratory Animal Medicine, 2nd edition. Academic Press: San Diego, CA. Chapter 20 – Biology and Health of Laboratory Fishes, p. 888.
Domain 4

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