2- Pharmacology of endoparasitic control

Question 1

What are the most commoly used classes of anthelmintic drugs used in animals

Answer 1

Benzimidazoles, Tetrahydropyrimidines/ imidazothiazoles and Macrocyclic lactones

Question 2

What are the 3 targets for anthelmintics?

Answer 2

Beta tubulin
Nicotinergic acetylcholine receptor
GABA receptor & glutamate-gated chloride channel

Question 3

What do benzimidazoles target?

Answer 3

Microtubules destruction
Binds to B-tubulin > inhibits polymerisation = causing abnormal microtubule formation

Disrupts intracellular homeostasis & energy metabolism

Question 4

What process are Excitatory (Act containing) neurons & Inhibitory (GABA containing) neurons important in a parasite?

Answer 4

Locomotion

Anthelmintics cause flaccid & spastic paralysis

Question 5

Explain the mechanism that causes flaccid paralysis

Answer 5

Ach antagonist

Question 6

Mechanism of cyclic octadepsipeptide

Answer 6

Acts on specific class of transmembrane G-protein coupled receptors

Question 7

Describe the mechanism of Aminoacetonitrile derivatives

Answer 7

MPTL-1 receptors, a unique kind of Ach receptor- spastic paralysis of treated nematode

Question 8

Describe the mechanism of action of spiroindole

Answer 8

Acetylcholine antagonist, causing flaccid paralysis and expulsion of parasites