2-drug names

Question 1

fluoxetine

Answer 1

prozac, SSRI

Question 2

venlafaxine

Answer 2

effexor, SNRI

Question 3

norfluoxetine

Answer 3

metabolized product of fluoxetine

Question 4

desvenlafaxine

Answer 4

metabolized product of venlafaxine

Question 5

vigabtrin

Answer 5

irreversible inhibitor of GABA-transaminase

for partial seizures

Question 6

tiagabine

Answer 6

inhibits GAT (GABA transporter that removed GABA from synaptic cleft)
good for partial seizures, "add-on" therapy

Question 7

carbazepine

Answer 7

use-dependent block of APVG Na channel, locks channels into inactivates state
prevents abnormal discharge rates

Question 8

parampanel

Answer 8

AMPA receptor allosteric inhibitor (Decreases excitatory influence)
good for seizures but not absense

Question 9

pentobarbital

Answer 9

barbiturate

allosteric modulator that increases length of time that GABA channel opens

Question 10

triazolam

Answer 10

benzodiazepine
allosteric modulator that increases frequency that GABA channel opens

sleep aid, 2h half life, causes memory impairment and violence

Question 11

diazepine

Answer 11

benzodiazepine

Question 12

zaleplon, zolpidem, zopiclone

Answer 12

z drugs, short half life, still bind to GABA-A (sleep)

Question 13

suvorexant

Answer 13

orexin receptor antagonist (sleep)

Question 14

haloperidol

Answer 14

1st gen typical antipsychotic

Question 15

chlorpromazine

Answer 15

1st gen typical antipsychotic

Question 16

clozapine

Answer 16

2nd gen atypical antipsychotic

Question 17

risperidone

Answer 17

2nd gen atypical antipsychotic

Question 18

nabilone

Answer 18

synthetic analog of THC, taken orally

Question 19

dronabinol

Answer 19

isomer of THC

good for nausea and appetite, taken orally

Question 20

nabiximols

Answer 20

1:1 THC and cannabinol (non psychoactive)

pain for MS and cancer

Question 21

rimonabant

Answer 21

inverse agonist at CB1

good for obesity but bad for depression and suicide

Question 22

AEA and 2-AG

Answer 22

endocannabinoids

retrograde neurotransmitters

Question 23

buprenorphine

Answer 23

partial agonist mu, antagonist delta kappa

treatment for pain and opioid addiction

Question 24

endorphins

Answer 24

mu

Question 25

enkephalins

Answer 25

delta

Question 26

dynorphins

Answer 26

kappa

Question 27

Ethosuximide

Answer 27

Blocks t type calcium to prevent abnormal firing rates

Absence seizures