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M > 2. Bioch > Flashcards

2. Bioch Flashcards

1
Q

Lipoprotéine role

A

Transport des m hydrophobe = lipide

Et vitamine liposoluble

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2
Q

AGL transport

A

Albumine

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3
Q

Répartition cholestérol jeun

A

VLDL -> 6-10%
HDL ->25-30%
LDL-> 60-65%

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4
Q

Coeur lipoprot

A

M hydrophobe

TG ou Ester de cholest

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5
Q

Enveloppe périphérique

A

M amphipile
Cholestérol libre
P°lip
Apolipoproteine

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6
Q

P°lip

A

pt hydrophile -> Gp Pâte + m

pt hydrophobe -> AG

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7
Q

Cholestérol libre

A

-> pt hydrophile -> OH

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8
Q

Apolipoprot

A

De structure B48 B100 -> øéchangeable, 1 exemplaire, lipoprot pro athérogene
Autres -> échangeable plsr…

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9
Q

Chylomicrons compo

A
  • dense mais + grand -> 1200 nm
    Maj TG > 80%masse
    Min cholestérol
    Apolippo B48 A E CII CIII
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10
Q

VLDL compo

A

Maj TG > 50%

Apo -> B100 et À E CII CIII

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11
Q

IDL compo

A

Ester de cholestérol = TG

Apo B100 et E

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12
Q

LDL compo

A

Min TG
Maj cholestérol
Ap B100

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13
Q

HDL compo

A

+ petit -> 10 nm
Coeur -> cholestérol
Enveloppe -> maj masse
Apo -> AI maj et AII

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14
Q

Rôle prot MTP

A

Prot microsomal

Stabilité (chaperonne) et transfert lip a travers mb RE sur B48

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15
Q

Échange de lip neutre du cœur entre chylomicrons et HDL

A

Chylo -> donner TG
HDL -> Ester cholestérol
Via cetp

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16
Q

Cetp

A

Associer aux apolipoprot

Transfert es Ester de cholestérol

17
Q

Transfert lip de surface aux HDL

A

P° lip et le cholestérol libre et apolipoprot échange AV CII E

18
Q

Hydrolyse tg du coeur

A

Transfomartation en remnant de chylo

19
Q

VLDL maturation ø obligatoire. Dans golgi

A

VTV (vésicule)
Enrichissement -> VLDL1 - dense mais + grand
Ø enrichissement -> VLDL 2 + dense

20
Q

Échange lip coeur neutre VLDL et HDL

A

VLDL -> donne tg
HDL-> donner Ester cholestérol
Cetp

21
Q

Hydrolyse tg coeur LPL VLDL -> IDL

A

Prêt apo AV CII

22
Q

Hydrolyse tg coeur LH IDL -> LDL

A

Perte apo E

Reste que B100

23
Q

Captation LDL

A

2/3 foie -> LDL-R

1/3 tissu périphérique LDL-R ubiquité (+++ glane surrénale et gonade)

24
Q

Insuline -

A

Lipolyse
Catabolisme des AG
Sécrétion des VLDL

25
Q

Insuline +

A

Lipogenese
Synthèse TG
Stockage intra hep TG

26
Q

LPL Z

A

M sq
Coeur
Foie

27
Q

LPL cofacteur

A

CII AV

28
Q

LPL substrat =TG

A

Chylomicrons

VLDL

29
Q

Régulation LPL

A

Aug LPL adipocytaire par insuline

+ de LPL par ligand PPARS -> fiibrates

30
Q

LH Z

A

Foie

31
Q

LH substrat

A

IDL
LDL
HDL

32
Q

Dosage. Act des lipasa sanguine

A

Injection héparine

33
Q

Enz pour estérifier cholestérol

A

ACAT

M (36 decks)

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