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Repro > 2 - Amenorrhoea > Flashcards

2 - Amenorrhoea Flashcards

1
Q

name 3 potential reasons for amenorrhoea?

A

problems with -

1) regulating hormones
2) ovarian function
3) uterus/ outflow tract

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2
Q

what is hypothalamic/ pituitary (HORMONAL) cause of amenorrhoea?

A

hypogonadotropic hypogonadism

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3
Q

what is hypogonadotropic hypogonadism?

A

Low FSH, LH

High Prolactin

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4
Q

hormonal causes - functional?

A

excessive weight loss/gain
over-exercising
stress

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5
Q

hormonal causes - chronic conditions?

A

diabetes
sarcoidosis
renal
TB

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6
Q

hormonal causes - intracranial space-occupying lesions?

A

prolactinoma
tumours
cysts

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7
Q

hormonal causes - infection/ trauma?

A

meningitis
intracranial bleed
Sheehan’s

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8
Q

hormonal causes - drugs?

A

glucocorticoids
anabolics steroids
opiates

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9
Q

hormonal causes - genetic?

A

Kallmann’s Syndrome (GnRH deficiency)

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10
Q

what is hypergonadotropic hypogonadism?

A

ovarian cause of amenorrhoea -

High/ normal FSH and LH

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11
Q

ovarian causes - genetic?

A

Turner’s syndrome (46X)

Fragile X

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12
Q

ovarian causes - ageing?

A

steep decrease in ovarian function >35 years

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13
Q

ovarian causes - POI/ POF?

A

1y ovarian insufficiency/ premature ovarian failure

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14
Q

ovarian causes - chronic illnesses?

A

autoimmune diseases

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15
Q

ovarian causes - cancer?

A

radio/ chemo- therapy

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16
Q

ovarian causes - infection?

A

TB

mumps oophoritis

17
Q

uterus/ outflow causes - congenital?

A

MRKH syndrome

absent uterus/ vagina

transverse vaginal septum

imperforate hymen

androgen insensitivity hormone

18
Q

uterus/ outflow causes - iatrogenic?

A

Asherman Syndrome

Radiotherapy (cervix/ pelvis)

19
Q

management of amenorhoea? (3)

A

lifestyle changes

optimise control of medical conditions

stop drugs/ switch to alternatives

20
Q

prolactinoma - management?

A

medical treatment

21
Q

intracranial SOL - management?

A

surgical treatment

22
Q

vaginal anomalies?

A

surgical treatment

23
Q

uterine adhesions?

A

surgical division hysteroscopic

24
Q

fertility management?

A

fertility preservation before therapy

IVF with own/ donor’s eggs

Repro (28 decks)

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