Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PATH3308 > 18. Musculoskeletal tissue banking > Flashcards

18. Musculoskeletal tissue banking Flashcards

1
Q

Dafaq is plus life?

A

Retrieve bone and tissue for transplant Legit bones Not barrow Real shit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two donor programs at plus life?

A

Living donor - Hip replacement - Femoral head usually discarded ~800 per year Cadaveric Program - Donation of long bones and tendons -Donate life refferals - ~12 per year

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the overview flowchart?

A

Refferal Donor screening Retrieval Testing Processing Testing Irradiation Release Distribution Implant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does cadaveric processing entail?

A

Removal of extraneous muscle and CT Cut into different sizes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is validation?

A

Validate equipment?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do you use musculoskeletal grafts for?

A

Orthopedics - Wear - Joint replacement -Infection - Fracture -Osteosarcoma -Fusion -Tendon/ligament reconstruciton Urology Maxillo-facial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What happened with harry?

A

Osteosarcoma Removed shoulder joint Bone bank had replacement GG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is bone made from?

A

70% inorganic (Calcium) 30 % organic (Collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the ideal properties of a bone graft?

A

Osteoconductive Osteoinductive Osteogenic Non-immunogenic Available Easy to use Affordable Fit for purpose Structural integrity Biologically safe Low risk of disease tranmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is Osteoconduciton?

A

Growth of bone through a scaffold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is osteoinduction?

A

Active/Passive Promotion of bone formation BMPS induce Make osteoblasts from osteoprogenitor cells What is passive bone formation Induction of of bone formation due to morphology etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is osteogeneis?

A

Normal bone formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the pros of an autograft?

A

Cost effective Osteoconductive Osteoinductive Osteogenic Non-immunogenic No risk of disease transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are cons of autograft?

A

Donor site morbidity Availability Longer surgery Structure Suitability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the pros of a allografts?

A

Cost effective Osteoconductive Can be fit for purpose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are cons of allografts??

A

Non osteogenic Limited osteoinduction

17
Q

What are demineralised bone matrix?

A

Allograft had had mineral phase removed Tissue exposed to strong acids Variable osteoinductivity

18
Q

What are pros of Demineralised Bone matrix?

A

Osteoconductive Osteoinductive Can be fit for purpose Can be used with carrier

19
Q

What is cons of DBM?

A

Not osteogenic Expensive Low risk of disease transmission Structural integrity Reaction to carriers

20
Q

What are biological summary of different grafts / bone treatments?

A

What is BMA? = Bone marrow aspirate

  • Take cells from iliac cells

PATH3308 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions