12. Stem Cells for Lung Therapy Flashcards
What is regenerative medicine?
The process of replacing or regenerating human cells, tissues or organs to restore or establish normal function
What are some cells that regenerate rapidly?
Hair, intestine, lung, liver
What are some cells that regenerate slowly?
Heart, Brain
How quickly do lung cells regenerate?
0.25 - 0.75% cells regenerate every day, complete renewal 100-400 days
What does IPF stand for?
Idiopathic Pulmonary Fibrosis
What does COPD stand for?
Chronic obstructuve pulmonary disease
What are the three main causes of inflammation and fibrosis in lung diseases?
IPF COPD Asthma
What is the hallmark of lung fibrosis?
Collagen deposition
What factors are involved in the clotting cascade and its role in lung fibrosis?
Intrinsic - Factor IXa - Factor XIa
Extrinsic - Tissue factor - Factor VIIa
What happens in the binding of PARS receptor by thrombin?
Proteinase acitvated receptors
Transmembrane coupled G protein
Portion is cleaved
Promotes wound healing and fibrosis TGFb
What is the pathway to lung fibrosis?
How has the coagulation cascade been targeted to treat lung fibrosis?
Direct thrombin inhibition
Activated protein C
Heparin
What is allosteric regulation?
The binding of a protein at a site other than the active site in order to regulate it
What current treatments are targeting PAR1?
Competitive PAR1 inhibitors - Peptide mimetics - Orally available non-peptide mimetics
Novel allosteric inhibitors
- CadenQ94
How are stem cells being used to treat lung fibrosis?
Engraftment
Growing stem cells on scaffolds
Stem cells as vectors
