157b - Liver Tumors Flashcards

1
Q

What is the #1 risk factor for hepatocellular carcinoma worldwide?

A

HBV

  • Usually develops in a background of cirrhosis
    • However, HBV can lead to HCC, even without cirrhosis
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2
Q

What is the major histologic finding of a hepatocellular adenoma?

A

No portal tract/bile duct

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3
Q

What are the risk factors for cholangiocarcinoma?

A

Anything that causes chronic inflammation in the biliary tree

  • Parasites
  • PSC
  • Inflammatory bowel disease (usually UC)
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4
Q

What kind of liver tumor would have:

Glands with dirty necrosis in the glandular spaces

A

Metastatic colon cancer

  • Usually multiple tumors
  • Background liver is not cirrhotic
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5
Q

Which liver tumor is associated with frequent activation of WNT signaling?

Which gene is usually mutated?

A

Hepatoblastoma

(most common liver tumor of childhood; presents <3 y/o)

Mutation in the APC gene (familial adenosis polyposis)

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6
Q

What is the most common primary hepatic malignancy of adults?

A

Hepatocellular carcinoma

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7
Q

What is the most common benign neoplasm of the liver?

How should it be managed?

A

Hemangioma

If asymtomatic, can just be monitored; no risk of malignant transformation

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8
Q

What are the risk factors for hepatocellular adenoma?

A

Contraceptive pills

Steroids/hormones for body building

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9
Q

What is the most common liver neoplasm?

A

Metastatic from another site

Most commonly colon, lung, or breast

(But HCC is the most common primary liver tumor)

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10
Q

What kind of liver tumor has:

Fibrotic stroma with malignant-appearing ducts

A

Cholangiocarcinoma

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11
Q

What is the most common liver tumor of early childhood?

How should it be managed?

A

Hepatoblastoma

Resection + chemotherapy

(these are malignant)

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12
Q

Is a hepatocellular adenoma benign or malignant?

How should it be managed?

A

Benign

Should be resected anyway -

Risk of growth, bleeding, malignant transformation

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