150b - Liver Histology and Basic Pathology Flashcards

1
Q

What is structure C?

A

Portal vein

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2
Q

Which metabolite of alcohol causes liver injury?

What enzyme ususally clears this metabolite?

A

Acetaldehyde

Converted to acetate by ALDH2

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3
Q

Describe the two-hit hypothesis of steatohepatitis

A
  1. Fat accumulation -> steatosis
  2. Oxidative stress to hepatocytes -> steatohepatitis
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4
Q

Which liver cells cause fibrosis?

A

Hepatic stellate cells

  • Normally quiescent
  • Activated by injury or inflammation
  • -> Division and proliferation
    • -> Kupffer cell activation
    • -> Deposition of scar matrix
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5
Q

What is structure B?

A

Hepatic artery

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6
Q

What is structure A?

A

Bile duct

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7
Q

What is structure D?

A

Central vein

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8
Q

What is the histologic hallmark of acetaminophen overdose?

A

Centrilobular necrosis (zone 3)

  • The centri-lobular hepatocytes typically metabolize acetaminophin
  • Hepatocytes around portal tracts (zone 1) will be normal)
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9
Q

List 4 histologic changes that may occur in steatohepatitis

A
  • Ballooning cells
  • Mallory bodies
  • Inflammatory infiltrate (neutrophils)
  • Pericellular and Perivenular fibrosis
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