150b - Liver Histology and Basic Pathology Flashcards
1
Q
What is structure C?
A
Portal vein
2
Q
Which metabolite of alcohol causes liver injury?
What enzyme ususally clears this metabolite?
A
Acetaldehyde
Converted to acetate by ALDH2
3
Q
Describe the two-hit hypothesis of steatohepatitis
A
- Fat accumulation -> steatosis
- Oxidative stress to hepatocytes -> steatohepatitis
4
Q
Which liver cells cause fibrosis?
A
Hepatic stellate cells
- Normally quiescent
- Activated by injury or inflammation
- -> Division and proliferation
- -> Kupffer cell activation
- -> Deposition of scar matrix
5
Q
What is structure B?
A
Hepatic artery
6
Q
What is structure A?
A
Bile duct
7
Q
What is structure D?
A
Central vein
8
Q
What is the histologic hallmark of acetaminophen overdose?
A
Centrilobular necrosis (zone 3)
- The centri-lobular hepatocytes typically metabolize acetaminophin
- Hepatocytes around portal tracts (zone 1) will be normal)
9
Q
List 4 histologic changes that may occur in steatohepatitis
A
- Ballooning cells
- Mallory bodies
- Inflammatory infiltrate (neutrophils)
- Pericellular and Perivenular fibrosis