142b - Clinical Features of Malabsorption Flashcards

1
Q

Where in the GI tract is iron absorbed?

A

Duodenum

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2
Q

Where in the GI tract are monosaccharides and amino acids absorbed?

A

Jejunum

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3
Q

How is protein malabsorption diagosed?

A

Clinical presentation + alpha-1-antitrypsin clearance

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4
Q

Which part of the GI tract is most affected by Celiac disease?

A

Small intestine

Proximal (duodenum) more affected than distal

=> problems with iron absorption

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5
Q

Which enzyme is useful in diagnosis in pancreatic exocrine insufficiency?

A

Elastase

  • Low fecal elastase is consistent with pancreatic insufficiency
    • Not included in PERT, therefore can still be measured in pts receiving exogenous pancreatic enzymes
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6
Q

Describe the presentation of fat malabsorption

A
  • Steatorrhea
    • Greasy, foul-smelling stools that float
    • Stick to toilet bowl, difficult to flush
  • Weight loss
  • Nutrient deficiencies
    • Fat soluble vitamins: ADEK
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7
Q

Where in the GI tract are lipids abosrbed?

A

Ileum

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8
Q

Which mineral deficiency is associated with celiac?

Why?

A

Iron deficiency

  • Iron is absorbed in the duodenum
  • Celiac disease often affects the duodenum more than other parts of the GI tract
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9
Q

What nutrients are abosrbed in the ileum?

A
  • Lipids
  • Fat soluble vitamins (ADEK)
  • Folate
  • Terminal ileum
    • Vitamin B12
    • Bile salts
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10
Q

In a patient with pancreatic exocrine insufficiency, what do you expect from their:

  • Fecal fat levels:
  • Fecal elastase levels:

(In general)

A
  • Fecal fat levels: high
  • Fecal elastase levels: low

Fecal elastase isn’t really an important enzyme, but useful diagnostically b/c not part of pancreatic enzyme replacement therapy

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11
Q

Where in the GI tract is vitamin B12 absorbed?

A

Terminal ileum

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