13a Mucosal immunity

Question 0

M cells

Answer 0

Cells of the follicle associated epithelium-

Transcytose pathogens and deliver them to dendritic cells

Question 1

Peyers patches

Answer 1

Lymph nodes just below the mucosal surface-
Follicle associated epithelium
Germinal center with b cells, surrounding parafolliccular cortex

Question 2

tolerogenic factors

Answer 2

Vitamin A/retinoic acid, TGFB, TSLP

Question 3

Mucosal associated immune trafficing molecules

Answer 3

CCR9, MadCam, CCL25

Question 4

IgA class switching promoters

Answer 4

TGFbeta, retinoic acid, IL6

Question 5

B cell costimulation

Answer 5

Complement recptor- CD21

TLRs

Question 6

Formation of Tregs

Answer 6

Dendritic cells present antigen and cary retinoic acid-

drives FOX3+ Tcells- Tregs

Question 7

Autoimmunity Associated genes

Answer 7

HLA genes
NOD2
ATG

Question 8

Celiac disease

Answer 8

Typer IV hypersensitivity - loss of tolerance to gluten

HLA-DQ2, DQ8 associated  (class II)
- Antibodies to tissue transglutaminase, endomysium, gliadin peptide

Question 9

IBD

Answer 9

• Microbiota tolerance breakdown: NOD cytoplasmic PRR gene, Autophagy genes
• Autoimmunity: Associated with HLA-DR(class2) and B27(class1)
• Type IV hypersensitivity (Crohns Th1 UC Th2)

Question 10

Food allergies

Answer 10

Type I hypersensitivity
IgE mediated response

IE eosinophilic esophagitis