05a Hepatic, biliary and pancreatic anatomy Flashcards
Sphincter of odi
Sphinctor blocking biliary/pancreatic duct that is tonically active
Lobes of liver
1- in back
2,3, Left most (removed for child liver transplant) drained by left hep v
4- just right of 2,3 Between intermediate and left hep v.
8,5right of intermed vein, left of right vein
7,6 right most sections, drained by left vein
5,6,7,8 removed for adult liber transplant- heathy patient can grow liver mass back
Parts of pancreas
Uncinate, head, neck, body, tail
Where does hindgut drain to?
Splenic vein -> Portal vein
Stellate cells
Cells located in space of disse that lay down collagen
Portal lobule
Areain the center of three central veins
PORTAL TRIAD IN CENTER
Hepatic acinus
Area between two central veins
Zone 1- closest to the triads (most succeptible to toxins and infective and toxins)
Zone 2-Intermediate
Zone 3 - Most ischemic
Kupfer cells
Macrophages interspersed within sinusoid epithelium responsible to phagocytosing debris and dealing with toxins
Liver vs. gallbladder bile
Gallbladder bile is much more concentrated
CCK
Released by duodenum after fatty meal
- Gallbladder contraction over 1 hour
- relaxes sphincter of oddi
-Causes pancreatic acini to produce digestive ezymes
Secretin
Stimulates release of sodium bicarb in biliary and pancreatic epithelium
(neutralize stomach acid, optimize pancreatic function)
Pancreatic secretions
Acini secrete Enzymes
- Trypsinogen, chymotrypsinogen, procarboxypeptidase digest proteins into AA and small polypeptides (trypsin inhibitor within pancreatic parenchyma)
- Pancreatic amylase- Digests carbs into matos and 3-9 Gluc. polymers
- Lipase- Triglyceriddes to Free FA and 2 Monoglycerides (After bile emusification
Bicarb secretion mech
Na/H+ exchanger pushes H+ out of basal side of cell, CAbreaks H2O and CO2 into H+ and HCO3+
