13 Cardiac output II Flashcards
What does venous return effect?
Atrial filling
What effects stroke volume?
- ventricular filling rate
- EDV (large causes muscle fibres to stretch more, making them work harder and get stronger)
Starlings Law:
What goes into the heart, must come out of the heart
-the energy of the contraction is proportional to the initial length of the muscle fibre
What are the key factors in venous return?
- muscular pumps
- respiratory pumps
- posture
what does the preload volume effect?
EDV directly
ESV indirectly
How does posture effect venous return?
standing causes pooling in the feet and less venous return
How do muscle pumps facilitate venous return?
Skeletal muscle contractions constrict venous return and since valves prevents back flow the blood has to go up
How do respiratory pumps facilitate venous return?
- when you breathe in diaphragm flattens increasing abdominal pressure and decreasing thoracic pressure
- this causes blood to move up from the abdomen into the thorax towards the heart
What are the filling times?
times taken for atria and ventricle to contract - directly linked to contractility
Contractility
contractile ability of cardiac muscle at a given preload volume
What is an inotropic effect?
effects the contractility of the heart (force of contraction)
what does a positive inotropic do?
increases contractility and therefore stroke volume
How do you cause an increase in contractility?
Increase the levels of intracellular calcium (from intracellular stores) as this increases the binding between the actin and myosin filaments
What has positive inotropic effects?
SNS and adrenaline
How does the PNS effect the heart?
through the vaygus nerve which effects atria because it doesn’t reach the ventricles.
-it slows HR and decreases contractility and so stroke volume