12. Preg Complications Flashcards
Spontaneous abortion/Miscarriage
Ends before 20 weeks; 80% occur within 1st 12 wks; 1 in 5 pregnancies end in miscarriage
Preterm Birth
Delivery of live infant prior to 37 wks; Incidence = 5-10%
IUFD
Intrauterine Fetal Demise - Fetal death in utero after 20 weeks or > 500 grams
General categories of IUFD Causes
Maternal, Fetal, Placental
Stillbirth
Delivery of fetus after 20 wks without evidence of life; Most stillbirths are actually IUFDs because most don’t die during delivery
Single most important test for a reproductive aged female with abdominal pain
Pregnancy test
Induced abortion
Planned procedure
Spontaneous abortion
Passage of fetus
Complete abortion
Spontaneous abortion of all products of conception
Incomplete abortion
Spontaneous abortion where some tissue is retained
MC reason for ER visit d/t abortion
Incomplete abortion resulting in hemorrhaging
Threatened abortion
Less than 20 weeks with viable pregnancy, vaginal bleeding & CLOSED CERVIX
Inevitable abortion
Less than 20 weeks, vaginal bleeding & DILATED CERVIX; preg loss unavoidable
Missed abortion
Retention of a failed IUP
Septic abortion
Any type of abortion complicated by a pelvic infection
Recurrent abortion
2 or more consecutive or a total of 3 spontaneous abortions
MCC of abortion in 1st 10 weeks
Genetic abnormality; 70% trisomies (Trisomy 16 MC)
MCC of abortion in weeks 14-18
Less likely genetic; More likely = maternal illness, uterine abnormality; placental factor; incompetent cervix
S/Sx of Abortion
HCG not properly increasing (should double every 48 hr in 1st trimester)
Blighted Ovum
AKA Anembryonic pregnancy = Failed development of the embryo so that only a gestational sac, with or without a yolk sac, is present
Complications of Abortion
Hemorrhage (MC); Sepsis; Emotional/Psychological
Threatened abortion tx
Bed rest (no data to support); Pelvic rest (NO INTERCOURSE!)
Incomplete abortion tx
Type & Screen; Rhogam; OB consult; Prep for OR or D&C
What should happen if patient with incomplete abortion passes a lot of tissue & cervix is open?
Avoid surgery if tissue is passed.
Complete abortion tx
Cervix is closed; pain and bleeding decrease. U/S shows no IUP and no ectopic. Re-exam shows closed os. Eval need for transfusion; Cytotec & RTC in 1 wk
Missed abortion tx
Watchful waiting. Most terminate spontaneously after 2 wks. Intervention necessary if no change after 4 wks.
Tx: uterine curettage or D & C
Complication of Missed Abortion
Prolonged retention can result in DIC
Septic abortion pathogens
E. coli; Strep fecalis, and Clostridia perfringes
Septic abortion tx
Resuscitation, broad spectrum ABX; tetanus toxoid; Early evacuation of uterus
Leading cause of Pregnancy Related Maternal Death in First Trimester
Ruptured ectopic pregnancy leading to hemorrhage
High risk factors for Ectopic Pregnancy
Previous ectopic pregnancy; Tubal pathology & surgery; IUD
Why do IUDs increase risk of pregnancy?
IUD slows rate of egg travel, so ectopic common if IUD fails
Signs/Symptoms of Ectopic Pregnancy
Tenderness; Adnexal mass; Uterine changes; “The Triad” = Pain, Vag bleeding; Amenorrhea
Pitfalls in Dx Ectopic Pregnancy
Atypical/absent pain; Failure to recognize factors; Passage of uterine tissue
MCC of Death in Young, Healthy Pregnant Woman
Unrecognized ectopic pregnancy
MC location of ectopic pregnancy
Ampulla
Worst Ectopic Pregnancy Outcomes Location
Cornual
Dx of Ectopic Pregnancy
Quantitative hCG levels greater than 6000 and absence of gestational sac; OR transvaginal U/S
TVUS findings of Ectopic Pregnancy
Shows fluid in the cul de sac; No IUP visualized
Management of Stable Pt following Ectopic Pregnancy
Rh- women should be given Rhogam (50 mcg IM)
Medical tx of Ectopic Pregnancy
Methotrexate
Methotrexate in Ectopic Pregnancy
Inhibits rapidly growing cells; Peak serum concentrations occur 2 hr after IM dose; half-life = 2-4 hr; remains in breast milk up to 6 mo
Methotrexate indications in pregnancy
No sonographic evidence of rupture; No fetal cardiac activity; Tubal mass
Contraindications of Methotrexate
Liver/renal dz; Bleeding diathesis
Complications of Methotrexate
DIC; Pelvic pain (even with effective tx); Ruptured ectopics can still have falling hCG
Signs of Methotrexate failure
Rising hCG; Decreasing hematocrit; Significant pelvic fluid; Unstable vitals
Surgical Tx of Ectopic Preg
Salpingostomy; Salpingectomy; Segmental resection; Fimrial resection
MC surgical tx of ectopic preg
Segmental resection
Salpingostomy
Making an incision on tube and removing pregnancy
Salpingectomy
Cutting tube out
Segmental resection
Cutting out affected portion of tube
Fibrial resection
“milking” the pregnancy out the end of the tube
Which treatment method reduces infertility after an ectopic pregnancy?
Medical tx (Methotrexate)
MCC of IUFD
Placental abruption
Placental abruption
Premature separation of placenta from uterus
What is the most common time for a placental abruption?
Third trimester; 80% just before onset of labor
Placental abruption grades
Grade 1 = Mild (40-48%); Grade 2 = Partial (27-45%); Grade 3 = Complete (15-24%)
External bleeding & Placental abruption grades
External grading does not necessarily correlate with grade of disruption
Grade 1 Placental Abruption: Mom’s Vitals/Baby’s Well-Being
Mom = WNL; Baby = FHR WNL
Grade 2 Placental Abruption: Mom’s Vitals/Baby’s Well-Being
Mom = BP nl; HR elev; Baby = FHR suggests distress
Grade 3 Placental Abruption: Mom’s Vitals/Baby’s Well-Being
Mom = BP low; HR elev; Baby = Fetal demise
Uterine Irritability
Grade 1 = Some irritability; Grade 2 = Irritability or tetany; Grade 3 = Tetany or pain
Placental Abruption Risk Factors
Maternal HTN associated with Grade 3; COCAINE; Predisposed to vascular dz.; Tobacco; Trauma; Chorio; Age > 35; PROM; Elevated AFP in 2nd trimester
Leading cause of Placental Abruption
Spousal abuse
Management of Placental Abruption
Fluids; Correction of coagulopathy; RhoGAM; Manage fetus (viable? C-section?)
Placenta Previa
PAINLESS!!! Sudden, profuse bleeding in 3rd trimester. Improper implantation of the placenta over the cervix.
3 types of Placenta Previa
Marginal; Partial; Complete
DX of Placenta Previa
U/S
1 cause of neonatal morbidity and mortality
Preterm Labor
Preterm Labor Dx
Reg, painful contractions (4@20 min or 8@60 min) AND Cervical dilation/effacement
Tx of Preterm Labor
Mag Sulfate or Nifedipine
Maternal contraindications to tocolysis
Severe maternal HTN; Pulm or cardiac dz; Advanced cervical dilation (>4cm); MATERNAL HEMORRHAGE!!!
Fetal contraindications to tocolysis
Fetal death or lethal anomaly; Fetal distress; Chorio; Hydrops; Severe intrauterine growth restriction
Cerclage
Tx for cervical incompetence
Cervical Incompetence
Painless cervical changes in 2nd trimester with recurrent preg loss
Pre-eclampsia dx
SBP >140; DBP > 90; Proteinuria >0.3 g in 24 hr urine; BP should be sustained; Repeat BP measurement
S/Sx of Pre-eclampsia
Edema of hands/face; Hyperreflexic DTR; Visual disturbances
Mild Pre-eclampsia tx
Bed rest; U/S for growth & fluid; Kick count;
Severe Pre-eclampsia tx
Bed rest & decreased stimuli; MgSO4; Steroids for FLM; Delivery
S/Sx of Eclampsia
Same as pre-eclampsi AND facial twitching, tonic-clonic seizure
HELLP Syndrome S/Sx
RUQ pain; N/V; Edema; Decreased H&H, Decreased plts; Increased LFTs; Jaundice; Visual changes
HELLP Syndrome Dx
Plt 600 IU/L;
AST >70 IU/L (nl = 40)
Tx of Eclampsia & HELLP
DELIVERY if fetus >34 wk, or nonreassuring tests of fetal status; Presence of severe maternal dz
Medical tx:
MgSO4
Hydralazine
Steroids to improve fetal lung maturity
Eclampsia & HELLP outcomes
DIC!
GBS in Preg
Frequent cause of asymptomatic bacteriuria, UTI, Chorio
2nd most common cause of bacteremia
GBS
Risk factor of GBS
Intrapartum fever >100.4F; PROM >18 hr; Prev delivery of affected infant; GBS bacteriuria during preg
When to screen for GBS
35-37 wks, unless GBS on urine culture or previously affected infant
GBS tx
ABX prophylaxis at least 4 hr before delivery;
PCN G
Amp
PCN Allergy? - Clinda or Vanc
Early Onset (
Septicemia; shock; pneumonia; and/or meningitis
Late Onset (7-89 d) Neonatal complicationso of GBS
Meningitis
PROM Risk Factors
Maternal infxn (any); Intrauterine infxn; CERVICAL INCOMPENCY; Multiple prev preg; Polyhydramnios; FH of PROM
PROM DX
Sterile speculum exam:
Pooling in posterior fornix
Nitrazine (litmus pape) - Blue = alkaline (pH 7-7.25)
Ferning - Fluid dried on slides looks like ferns
Primary complication of PROM
Chorio
Management of Chorio d/t PROM
Deliver & start ABX
Management of Pre-PROM
ABX; Steroids; Tocolytics for transport to large hospital