06. Infertility Flashcards

1
Q

Primary infertility

A

Failure to achieve pregnancy where the female partner has NOT previously been pregnant

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2
Q

Secondary infertility

A

Involuntary infertility with proven past fertility

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3
Q

Fecundity

A

The ability for fertilization to occur; Measured as “fecundity rate”

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4
Q

Sterility

A

Absolute inability to have children

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5
Q

Spermatogonia & oogonia

A

Germ cells that will eventually develop into mature sperm or egg

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6
Q

Where does spermatogenesis occur?

A

In the seminiferous tubules of the testes

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7
Q

Sertoli cells

A

Cells that stretch from the lumen to the edge of the seminiferous tubule that nourish developing sperm. Form a blood-testis barrier to control spermatogenesis & inhibit this before puberty.

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8
Q

Granulosa cells

A

Somatic cells closely associatd with oocytes that aid oocyte maturity and ovulation.

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9
Q

Normal rate of pregnancy

A

85% of couples attempting conception will be successful within 1 yr

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10
Q

Infertility

A

Failure to become pregnant after 1 yr

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11
Q

Infertility >35 y/o

A

Failure to become pregnant after 6 mo

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12
Q

Peak age of fertility for females

A

24-25 yrs

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13
Q

Maximum age for successful pregnancy

A

52

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14
Q

Identified causes of female infertility

A

Mechanical factors; Cervical factors; Ovulatory dysfunction/failure

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15
Q

Causes of ovulatory dysfunction

A

PCOS; Stress; Thyroid dz; Hyperprolactinemia; Meds (any CNS drug can increase prolactin); CNS tumors; Aging

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16
Q

MCC of Male Infertility

A

Varicocele

17
Q

6 Factors to Evaluate in Infertility Work Up

A

Ovulation; Male factor; Cervical factor; Uterin factor (fibroids); Tubal factor; Pelvic factor

18
Q

When should FSH be tested during evaluation of infertility?

A

Day 3

19
Q

When should progesterone be tested during evaluation of infertility?

A

Day 21

20
Q

When is IVF indicated as a first line tx of infertility?

A

Severe tubal damage or testicular failure

21
Q

Stages of IVF

A

1: Ovarian stimulation & monitoring
2: Egg retrieval
3: Fertilization
4: Embryo transfer