11.4 Transport Of Gasses And Control Flashcards
Air is a
Mixture of gasses (partial pressure aka ratio of each component)
Oxygen transport
Bound to hemoglobin within erythrocytes (iron containing protein)
Carbon dioxide transport
- some bound to hemoglobin (5-10%
- some dissolved in plasma (5-10%)
- majority (70-80%) becomes bicarbonate ion once it hits bloods plasma. CO2+H20 <-> HCO3- + H+
Alveolar air has
Higher partial pressure of Oxygen (and lower pCO2) than the capillary
Tissues have ____ pO2 and ____ pCO2 compared to Capillary
Lower, higher
Hemoglobin affinity for O2
Varies under certain conditions (only lets go of O2 if a tissue needs it)
When O2 sat is high, hemoglobin affinity is high, and vice versa
Hemoglobin decrease affinity factors
- increase carbon dioxide (burning fuels) CO2 binds and causes release O2
- Low pH (acidic), protons affect hemoglobin release O2
- increase temperature
Hemoglobin increase affinity factors
- Carbon Monoxide bound (higher affinity)
- low CO2, high pH, decrease temp
Control of pulm ventilation
CNS & PNS chemoreceptors (aorta and carotid) send info to Medulla Oblongata
Both effected by CO2, only PNS can be affected by O2
Key driving factor of respiration
CO2
Pulmonary ventilation adjusts
CO2 in blood, negative feedback for chemoreceptors
Too much CO2 in blood
Respiratory disorders (prolonged CO2) Can lead to hypoxic drive.
Increase CO2 leads to Increase H2CO3
Which leads to acidic blood (low pH) called respiratory acidosis