11.1 Flashcards
DNA is a nucleic acid composed of nucleotides
-nucleotides consist of
1. 5 carbon sugar called deoxyribose
2. Nitrogenous base (A,T,C, G)
3. Phosphate group (PO4)
Attached to a 5’ carbon of sugar
Purines
Adenine and thymine (2 h bonds)
Pyrmadines
Guanine and cytosine (3 h bonds)
Nucleotides are linked together by
Phosphodiester bonds
Phosphodiester bonds
Formed between the phosphate group of 1 nucleotide and the 3’ OH of another nucleotide
Chargaffs rules
Amount of adenine=amount of thymine
Amount of cytosine=amount of guanine
Maurice Wilkins/ rosalind Franklin
-Performed x ray diffraction studies to identify 3-D structure
-Discovered that DNA is helical
-DNA has a diameter of 2 nm and makes a complete turn of the helix every 3.4 nm
Watson crick model of DNA
-deduced the structure of DNA using evidence from Franklin, chargaff, and others
-did not perform a single experiment related to DNA
-proposed a double helix structure
-2 nucleotide strands