11 Molecular Basis of Cancer 2 Flashcards
Apoptosis typically looks like?
- nuclear condensation
- cell shrinkage
- scattered
necrosis typically looks like?
karryorhexis, karryolysis, pyknosis, inflammation, group
T/F apoptotic cells cut their DNA into specific chunks?
T (unlike necrosis)
T/F p53 activates apoptosis?
T
What is the mechanism of p53 action?
working p53 catches DNA damage-> transcribe p21 to arrest cell cycle, bax to apoptosis, or GADD45 for DNA repair
What creates hair loss, GI crypt death, bone marrow death in radiation treatment?
p53
T/F BOTH p53 and Rb must be lost to allow tumor development?
T
2 genes at the same Ink4 locus encode what?
- p16 activates Rb (p16 inhibits cyclin D which inhibits Rb)
- p14 activates p53 (p14 inhibits MDM2 which inhibits p53)
knocking out Ink4 would lead to?
cancer! (Rb inactivation)
activation of Rb leads to?
cell cycle shutdown at G1/S
T/F p53 is usually found in high levels in tumors?
T. (p53 in mutated form which can’t feedback to MDM2 to say “degrade me!”)
bcl2 does what?
stops apoptosis (present in follicular B cell lymphomas!)
t14:18 translocation should ring a bell for?
-Ig heavy chain enhancer stuck next to Bcl-2 (b-cell lymphomas)
how many doublings in a normal cell till senescence?
~60
T/F telomere shortening creates genetic instability when p53 is dead?
T
