1.1. Basic Renal Process - Filtration Flashcards
What is the process if the filtration?
The formation of an essentially protein-free filtrate of plasma
Where does the process of filtration occur?
At the glomerular capillaries
How much of the plasma, from the afferent arterioles, is filtered through the glomerular capillaries?
20%
Where is the plasma filtered from / into?
From - The glomerular capillaires
Into - Bowman’s capsule
What happens to the remainder of the plasma, which isn’t filtered into the Bowman’s Capsule?
It passed into the efferent arterioles
Where does the blood, which passes into the efferent arterioles, travel to?
The peritubular capillaries
What are the three layers of the glomerular capillary wall?
- Endothelial Cells
- Basal Lamina
- Podocytes
What is special about the Glomerular Endothelial Cells?
It is fenestrated as to prevent blood cells from being filtered, but allowing smaller components of plasma
What is special about the Glomerular Basal Lamina?
This prevents larger proteins from being filtered, but allowing smaller components of plasma
What is special about the Glomerular Podocytes?
They form a Slit Membrane between Pedicles of the Podocytes, which prevent medium sized proteins from being filtered, but allowing smaller components of plasma
How does glomerular filtration occur?
Through the balance of:
1. Hydrostatic Forces
2. Oncotic Pressure
Note - This is the same method as fluid filters through capillaries
What force favours filtration?
Hydrostatic forces
What force favours reabsorption?
Oncotic pressure (Starling’s Forces)
Is the pressure in the Glomerular Capillaries high or low?
High
What is responsible for the high glomerular capillary pressure?
- The afferent arteriole
2. The efferent arteriole
