11. Animal Physiology Flashcards
11.1 What are the steps of the immune response (antibody production)?
1) Pathogens are ingested by macrophages, antigens are absorbed and displayed
2) T-cells w/ specific receptors bind to antigens and activate
3) Helper T-cells bind to antigen specific B-cells and signal with the release of protiens
4) Activated B-cells undergo mitosis, producing a large number of plasma cells, but also some memory cells
11.1 What is a plasma cell?
Plasma cells are mature B-lymphocytes.
-Expanisve RER to produce a lot of antibodies
11.1 What are antigens?
Every organism has unique molecules on their cell’s surface
- Most common = protiens + polysaccharides
11.1 Antibody modes of destruction
P - recipitation: soluble pathogens become insoluble
A: gglugation: Links cell-bound antigens together causing clumping
N: uetralisation: covers dangerous parts
I: nflamation: Triggers histamine release
C: Complement activation: complement protiens perforate cell (lysis)
11.1 What are histamines?
Histamines dialate blood cells to allow more fluid w/ immune components
- Mast cells secrete this
Effects: Allergy response
11.1 What are mast cells?
Immune cells in connective tissue
11.1 What are monoclonal antibodies?
Highly specific, pure antibodies
- produced by hybridoma cells
- used as treatment + diagnosis of diseases
EX: hCG antibodies for pregnancy test
11.1 How are hybridoma cells produced?
1) A mouse is injected with an antigen and produces plasma cells
2) The plasma cells are fused with myeloma cells (tumor cells)
3) The resulting cell is the hydbridoma cell
11.1 What are myeloma cells?
Cancer plasma cells
11.2 What is the purpose of bones and exoskeletons?
Provide anchorage for muscles and act as levers
11.2 Lever diagram parts
F: Fulcrum, (triangle)
R: Resultant Force
E: Effort
11.2 What are the three types of movement levers
First Class: Traditional lever
Second Class: R + E are on the same side (E is furthest), F on opposent
Third Class: R+ E on same side (E closer to middle), F on opposet
11.2 What are synovial joints?
Joints that surrond the surface of two bones, they allow certain movement but not others
11.2 Six types of sinovial joints ( in order of mobility)
Plane joints
ex: between tarsal bones of foot
Hinge Joints
ex: elbow
Pivot Joint
ex: vertebrae
Condyloid
ex: wrist (radius + carpal)
Saddle
ex: Base of thumb
Ball and socket:
ex: Hip
11.2 Logistics of skeletal muscles
These work in antagonistic pairs, where one contracts and one extends
11.2 Draw a human elbow joint
11.2 What is the microstructure of muscle fibers?
Bundles of myofibrils (muscles cells) are surronded with a sacrolemma with a sarcoplasmic reticulum wrapping around all fibrils
- there are extra nuclei and mitochondria
11.2 Structure of a myofibril
Myofibrils are composed of units called sacromere:
Each sacromere spans the length between z-lines.
There is a light band of actin and the dark band of myosin in the middle
Each thick myosin is surronded by six thin actin
11.2 Draw a sacromere
11.2 Mechanism of muscle contraction
Mysoin heads bind to sites on actin and cause cross-briging
-using ATP they exert force and the actine slides along which shorterns the sacromere
11.2 What controls muscle contraction
Relaxed muscle: Tropomysosin blocks binding site on actine
- When motor nueron signals, sacroplastic reticulum releases calcium
- Calcium binds to troponin which causes tropomyosin to move
11.2 Role of ATP in muscle contraction
1) Myosin head attaches to actin binding site forming cross-bridge
2) ATP binds to head, causing detachment
3)ATP is hydrolysed into ADP + P causing myosin head to shift
4) Head attaches to new binding site
5) ADP+P are released causing head to move back to original positi, sliding actin
11.3 Draw a kidney