11/6 - Hematopoietic and Lymphoid System Flashcards
Thalassemias are a group of [inherited OR noninherited] caused by defects in the synthesis of one or more of the hemoglobin chains
inherited hematologic disorders
___ thalassemia is caused by reduced or absent
synthesis of alpha globin chains
___ thalassemia is caused by reduced or absent
synthesis of beta globin chains
alpha, beta
Genetically heterogenous disorders caused by germline mutation that decreases the synthesis of either a-globin or ß-globin, leading to anemia, tissue hypoxia, and red cell hemolysis related to imbalance in globin chain synthesis
thalassemia
imbalances of globin chains in thalassemias cause what
Imbalances of globin chains cause hemolysis and impaired erythropoiesis (production of RBC)
describe alpha and beta chains in thalassemia
The 2 a-chains of HbA are encoded by an identical pair of a-globin genes on chromosome 16
The 2 ß-chains are encoded by a single ß- globin gene on chromosome 11
impaired beta-globin synthesis results in anemia by what mechanisms
The deficit of HbA (adult hemoglobin) synthesis produces “underhemoglobinized” hypochromic, microcytic red cells with subnormal oxygen transport capacity
Diminished survival of RBCs and their precursors, which results from imbalance in the a- and ß-globin synthesis
beta-thalassemia major
beta-thalassemia minor
beta-thalassemia intermedia
what are normal hemoglobins
F (alpha2, gamma2)
A (alpha2, beta2)
A2 (alpha 2, delta 2)
what are abnormal hemoglobins
H (beta 4)
Barts (gamma 4)
hemoglobin consists of what
iron-containing heme ring and four globin chains: two alpha and two nonalpha
T/F: At birth, HbF accounts for approximately 80% of hemoglobin. HbA accounts for 20 percent
TRUE
does transition from HbF to HbA begin before or after birth
before birth
by what age do healthy infants transition to mostly HbA, a small amount of HbA2 and negligible HbF
six months of age
silent carrier
alpha-thalassemia trait
HbH disease
hydrops fetalis
what chromosome is affected for alpha thalassemia
chromosome 16
what disease:
- Spiky shaped and short roots
- Taurodontism
- Attenuated lamina dura
- Enlarged bone marrow spaces
- Small maxillary sinuses
- Class Il malocclusion: short mandible, a reduced posterior facial height -Chipmunk faces (Narrow maxilla, smaller incisors widths)
- Higher caries but no increase in gingivitis or periodontitis
thalassemia
CHIPMUNK face buzz
thalassemia
what can be seen on pano radiograph of patient with thalassemia
- thin mandibular inferior cortex
- enlarged bone marrow spaces
- short spiky roots of MANDIBULAR molars
- thin lamina dura
- indiscernible border of mandibular canal
In severe cases of ___ and ___, the loss of the outer table of the calvarium results in perpendicular trabeculae radiating outward from the inner table, in response to the intracranial pressure, giving a “hair-on-end” appearance
Sickle Cell Anemia and thalassemia
BOARD!!
thalassemia complications
- multiple blood transfusions and continued absorption of intesintal iron causing iron overload
- endinocrinopahties
- splenomegaly
what are endocrinopathies that can cause thalassemia complications
hypogonadism and DM (may occur in adolescents and adults)
what invitably deveops in symptomatic thalassemia and can worsen the anemia and occasionally cause neutropenia and thrombocytopenia
splenomegaly
what mechanical traumas cause hemolytic anemias
- Artificial heart valves
- Disseminated intravascular coagulation (DIC)
- Hemolytic uremic syndrome
what is a rare life threatening disease-causing destruction of RBC, which can lead to cause of kidney failure? due to what bacteria?
hemolytic uremic syndrome (HUS) causing anemia due to E. Coli diarrheal infection
what hemolytic anemias cause infection of red cells
malaria
what are the two main mechanisms that malaria infection causes hemolytic anemia
- non-immune mediate hemolysis
- immune mediat ehemolysis
___: direct destruction of the red blood cells (RBCs) by the PARASITE, and depends on the type of malaria and the percentage of parasitemia (at the end of infection cycle, the blood cells rupture)
Non-immune mediated hemolysis
___: few cases of autoimmune hemolytic anemia in malaria patients are reported; antibodies form against the body’s own ANTIBODIES and destroy them
Immune mediated hemolysis
what are anemias of decreased erythropoiesis
- nutritional deficiences
- immune-mediate injury of progenitors
what nutritional deficiencies cause anemias of decreased erythropoisesis
- iron deficiency anemia
- megaloblastic anemia (B12 deficiency anemia and folate deficiency)
- pernicious anemia
Caused by bleeding or inadequate iron intake
Results in insufficient hemoglobin synthesis and hypochromatic, microcytic red cells
iron deficiency anemia
crucial biologic functions of iron
- DNA synthesis
- cell proliferation
- energy production
- respiration
how has the human body evolved to conserve iron
recycle of iron after breakdown of red cells
absorption of iron is limited to how many mg daily
1 to 2 mg daily
Most of the iron needed daily, about 25 mg per day, is provided through what
recycling by macrophages that phagocytose senescent erythrocytes
T/F: Iron-deficiency anemia is chronic and frequently`asymptomatic and may often go unnoticed
true
non-specific symptoms of iron deficiency anemia
- weakness
- fatigue, difficulty in concentrating
- poor work productivity
symptoms of severe iron deficiency anemia in pregnancy
- increased risk of preterm labor
- low neontal weight
- increased newborn and maternal mortality
what this:
Caused by deficiency of Vit B12 or folate that leads to inadequate synthesis of thymidine and defective DNA replication
megaloblastic anemia
what this:
Results in enlarged abnormal hematopoietic precursors (megaloblasts), ineffective hematopoiesis, macrocytic anemia, and (in most cases) pancytopenia
megaloblastic anemia
what is neecssary for DNA synthesis
Vit B12 and folate
uncorrected deficiency of VitB12 leads to what
demyelinating process as well as anemia
in Vit B12, it initially involves peripheral nerves, but when as disease progresses, it involves the spinal cord. Is this reversible?
NO! irreversible
symptoms of vit B12 deficiency resulting in anemia
- Symmetrical numbness of hands & feet
- Cognitive impairment in older individuals may resemble Alzheimer Disease; neuropsychiatric state may develop (megaloblastic madness)
oral manifestation of Vit B deficiency
erythema and depapillation of tongue
treatment of B12 deficiency
- initial: parenteral injections of Vitamin B12
- when large abnormalities: large daily does of Vit B12 can be used since 1% of oral dose is aborbed without need for intrinsic factor binding
what this:
Malabsorption of Vitamin B12 due to autoimmune gastritis is the most common cause
pernicious anemia
where is Vit B12 normally aborbed
distal ileum
in pernicious anemia,aAutoimmune gastritis and reduction in gastric acid ___ to ___ and subsequent binding of Vit B12- intrinsic factor complex to IF receptors in the terminal ileum
prevents binding of Vit B12 to
intrinsic factor (produced by parietal cells of stomach)
who produces intrinsc factor? where
parietal cells of stomach
in pernicious anemia,aAutoimmune
gastritis and reduction in gastric
acid preents binding of Vit B12 to intrinsic factor and ___ to __ in the ___
subsequent binding of Vit B12- intrinsic factor complex to IF receptors in the terminal ileum
what this:
Diminished dietary intake
Increased demand (pregnancy)
Metabolic problems (alcoholism)
Drug-induced (methotrexate)
folate (folic acid) deficiency