1. Neurophysiology part II

Question 1

___ toxin: blocks voltage gated Na+ channels

Answer 1

tetrodotoxin
- blocks AP
= death, paralysis

Question 2

tetrodotoxin blocks ____ channels. This cause a ____ not to be propogated resulting in death/ paralysis

Answer 2

voltage gated Na+ channels

causes an AP not to occur

Question 3

____ toxin: blocks vesicle fusion at neuromuscular jxn

Answer 3

botulimum

- blocks actin moving myosin
cant move the forehead

Question 4

____ toxin: blocks K+ channels

Answer 4

apamin

- blocks repolarization = spasms

Question 5

apamin blocks K+ channels and causes ___ to not occur

Answer 5

repolarization

Question 6

Curare toxin blocks ___ receptors

Answer 6

nicotinic receptors (AcH)
effect- M weakness

Question 7

What are the two types of postsynaptic respinsees to NT release in the synapse

Answer 7

1. Graded response (aka electrotonic)

2. AP

Question 8

EPSP is mediated by ___ ion influx

Answer 8

Na+

Question 9

IPSP is mediated by ____ ion influx

Answer 9

Cl-

Question 10

____ are the sum result of graded responses

Answer 10

AP

Question 11

_______ theory: only specific neurons respond to NT release

Answer 11

Lock and key receptor specificity

Question 12

What are two ligand-mediated receptors?

Answer 12

1. iontrophic

2. metatrophic

Question 13

____ is a ligand mediated receptor that requires G protein coupling

Answer 13

Metatrophic ligand

slower than iontrophic

Question 14

Ea Neuron has its own ___ identity

Answer 14

NT identity

Question 15

____ is the most prevalent excitatory NT

Answer 15

Glutamate

Question 16

___ pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate

Answer 16

excitoxic

Question 17

____ is the most prevalent inhib NT

Answer 17

GABA

- binds post synaptic & binds with Ca2+ (ISPS)

Question 18

AA NT inhibitor that is found mainly in the SC

Answer 18

glycine

Question 19

Glutamate and GABA are recycled by ___

Answer 19

astrocytes