1-33 Breast Cancer genetics Flashcards
1
Q
carcinoma
ductal
A
epithelial cells that start invading
proliferation of ductal epithelial cells
2
Q
Marker testing of breast cancers
A
Progesterone receptor, Estrogen receptor, HER2/neu
3
Q
Breast cancer incidence
A
1 in 8 women will get
most common cancer diagnosed in 2019
1 in 10 carry germline risk variant of those who will get breast cancer
4
Q
founder alleles in breast cancer
A
ashkenazi women mostly exhibit the same specific mutations:
BRCA1: 185, 5382
BRCA2: 617
5
Q
Cascade screening
A
more cost effective method to assess single variant mutations in family lines
dont have to run a whole sequencing panel
very cheap, correct surveillance path, this will motivate insurance companies to cover this type of medically indicated tests
