1-2 ATP Synthesis and Energetics

Question 1

Respiration

Answer 1

Energy production from carbs, lipids, proteins

Input oxygen, ADP, Pi
output CO2 and ATP

Question 2

Methods for coupling ATP hydrolysis to work

Answer 2

1. Mechanical: protein changes conformation when bound to ATP vs ADP
2. Transport work: transfer of a phosphate to a transport channel protein changes the transporters conformation
3. Biochemical work: coupling fav to unfavorite rxns OR creation of activated intermediates

Question 3

Energy currency of cell

Answer 3

High energy compounds

PEP, creating-P, 1,3 bisphosphoglycerate, succinylcholine-coA

All able to donate a P to produce ATP

Question 4

Activated intermediates

Answer 4

1. High E phosphate bonds (ex UTP, ATP, UDP-glucose)

2. High E thioester bonds (ex acetyl—S-CoA broken do we to citrate and relates HS-coA via breaking)

Question 5

Enzyme used to regulate ATP levels

Answer 5

Adenylate kinase 2ADP—>AMP +ATP

During exercise states a large build up of AMP and ADP compared to resting levels

Question 6

Most reduced element

Most oxidized

Answer 6

Methane high energy

CO2 low energy

Question 7

Exergonic

Endergonic

Answer 7

Spontaneous, deltaG<0

Non-spontaneous, delatG>0

Question 8

Gibbs free E

Answer 8

Related to the amount of available products over reactants therefore the free energy can change if we manipulate product/reactant availability (le chatlier)

If deltaG=0, then at equilibrium and P=R