02 IRON KINETICS + laboratory assessment Flashcards
A protein of hepatic origin that inhibits ferroportin from transporting iron out of the enterocyte
Hepcidin
All cells except ___ can store iron
mature RBC
1 ferritin is equal to ___ iron ion reserve
4000
A partially degraded ferritin that is less metabolically active and available than ferritin
Hemosiderin
An indicator of available transport iron
Serum Iron
Serum iron levels ___ (increase/decrease) in the morning
increase
Serum iron levels ___ (increase/decrease) after recent ingestion of iron containing food
increase
Measurement of transferrin level
Total binding iron capacity
Total iron binding capacity is ___ proportional to the intracellular iron
inversely
An indirect indicator of transport iron and transferrin level
% transferrin saturation
% transferrin saturation is ___ proportional to serum iron
directly
___ of transferrin is saturated of iron
1/3
Formula for % transferrin saturation
SI/TIBC x 100
An indicator of iron storage
Ferritin
Inflammation causes a falsely ___ ferritin
elevated
A visual qualitative assessment of tissue iron stores
Prussian blue staining
Gold standard for assessment of body iron stores
Prussian blue staining
Specimen of choice for prussian blue staining
bone marrow and liver biopsies
A sensitive marker to diagnose iron deficiency anemia
Soluble transferrin receptor
Differentiates anemia of chronic inflammation and and iron deficiency anemia with chronic inflammation
Soluble transferrin receptor log ferritin ratio index
When intracellular iron drops, the cell expresses ___ on the membrane
transferrin receptor (TfR)
Reflects the status of erythropoiesis in the 24-hour period
Hemoglobin of reticulocytes (MCH)
Provides a real-time assessment of iron available for hemoglobin production
Hemoglobin of reticulocytes (MCH)
Identify the anemia:
High serum iron
High ferritin
Low TIBC
High % saturation
Sideroblastic anemia
Identify the anemia:
Low stored iron
Low ferritin
High TIBC
Low % saturation
High sTFR
(-) Prussian blue staining
Iron deficiency anemia
Identify the anemia:
High serum iron
High ferritin
Low TIBC
High % saturation
Normal sTFR
(+) Prussian blue staining
Hemochromatosis
Identify the anemia:
High stored iron
High/normal ferritin
Low TIBC
Low % saturation
Normal sTFR
(+) Prussian blue staining
Anemia of chronic inflammation
This reduces ferric to ferrous ion
Duodenal cytochrome b
Transports ferrous ion inside the enterocyte
Divalent metal transporter 1
Heme is transported to enterocyte through ___
heme transporter
This releases iron from protoporphyrin IX to be absorbed by the enterocyte
Heme oxygenase 1
Stored iron
Ferritin
Transports iron out from enterocyte to circulation
Ferroportin
Regulates iron homeostasis
Hepcidin
Reoxidizes ferrous to ferric ion to bind with transferrin
Hephaestin
