02 IRON KINETICS + laboratory assessment Flashcards

1
Q

A protein of hepatic origin that inhibits ferroportin from transporting iron out of the enterocyte

A

Hepcidin

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2
Q

All cells except ___ can store iron

A

mature RBC

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3
Q

1 ferritin is equal to ___ iron ion reserve

A

4000

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4
Q

A partially degraded ferritin that is less metabolically active and available than ferritin

A

Hemosiderin

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5
Q

An indicator of available transport iron

A

Serum Iron

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6
Q

Serum iron levels ___ (increase/decrease) in the morning

A

increase

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7
Q

Serum iron levels ___ (increase/decrease) after recent ingestion of iron containing food

A

increase

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8
Q

Measurement of transferrin level

A

Total binding iron capacity

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9
Q

Total iron binding capacity is ___ proportional to the intracellular iron

A

inversely

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10
Q

An indirect indicator of transport iron and transferrin level

A

% transferrin saturation

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11
Q

% transferrin saturation is ___ proportional to serum iron

A

directly

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12
Q

___ of transferrin is saturated of iron

A

1/3

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13
Q

Formula for % transferrin saturation

A

SI/TIBC x 100

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14
Q

An indicator of iron storage

A

Ferritin

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15
Q

Inflammation causes a falsely ___ ferritin

A

elevated

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16
Q

A visual qualitative assessment of tissue iron stores

A

Prussian blue staining

17
Q

Gold standard for assessment of body iron stores

A

Prussian blue staining

18
Q

Specimen of choice for prussian blue staining

A

bone marrow and liver biopsies

19
Q

A sensitive marker to diagnose iron deficiency anemia

A

Soluble transferrin receptor

20
Q

Differentiates anemia of chronic inflammation and and iron deficiency anemia with chronic inflammation

A

Soluble transferrin receptor log ferritin ratio index

21
Q

When intracellular iron drops, the cell expresses ___ on the membrane

A

transferrin receptor (TfR)

22
Q

Reflects the status of erythropoiesis in the 24-hour period

A

Hemoglobin of reticulocytes (MCH)

23
Q

Provides a real-time assessment of iron available for hemoglobin production

A

Hemoglobin of reticulocytes (MCH)

24
Q

Identify the anemia:

High serum iron
High ferritin
Low TIBC
High % saturation

A

Sideroblastic anemia

25
Q

Identify the anemia:

Low stored iron
Low ferritin
High TIBC
Low % saturation
High sTFR
(-) Prussian blue staining

A

Iron deficiency anemia

26
Q

Identify the anemia:

High serum iron
High ferritin
Low TIBC
High % saturation
Normal sTFR
(+) Prussian blue staining

A

Hemochromatosis

27
Q

Identify the anemia:

High stored iron
High/normal ferritin
Low TIBC
Low % saturation
Normal sTFR
(+) Prussian blue staining

A

Anemia of chronic inflammation

28
Q

This reduces ferric to ferrous ion

A

Duodenal cytochrome b

29
Q

Transports ferrous ion inside the enterocyte

A

Divalent metal transporter 1

30
Q

Heme is transported to enterocyte through ___

A

heme transporter

31
Q

This releases iron from protoporphyrin IX to be absorbed by the enterocyte

A

Heme oxygenase 1

32
Q

Stored iron

A

Ferritin

33
Q

Transports iron out from enterocyte to circulation

A

Ferroportin

34
Q

Regulates iron homeostasis

A

Hepcidin

35
Q

Reoxidizes ferrous to ferric ion to bind with transferrin

A

Hephaestin