02 IRON KINETICS + laboratory assessment

Question 1

A protein of hepatic origin that inhibits ferroportin from transporting iron out of the enterocyte

Answer 1

Hepcidin

Question 2

All cells except ___ can store iron

Answer 2

mature RBC

Question 3

1 ferritin is equal to ___ iron ion reserve

Answer 3

4000

Question 4

A partially degraded ferritin that is less metabolically active and available than ferritin

Answer 4

Hemosiderin

Question 5

An indicator of available transport iron

Answer 5

Serum Iron

Question 6

Serum iron levels ___ (increase/decrease) in the morning

Answer 6

increase

Question 7

Serum iron levels ___ (increase/decrease) after recent ingestion of iron containing food

Answer 7

increase

Question 8

Measurement of transferrin level

Answer 8

Total binding iron capacity

Question 9

Total iron binding capacity is ___ proportional to the intracellular iron

Answer 9

inversely

Question 10

An indirect indicator of transport iron and transferrin level

Answer 10

% transferrin saturation

Question 11

% transferrin saturation is ___ proportional to serum iron

Answer 11

directly

Question 12

___ of transferrin is saturated of iron

Answer 12

1/3

Question 13

Formula for % transferrin saturation

Answer 13

SI/TIBC x 100

Question 14

An indicator of iron storage

Answer 14

Ferritin

Question 15

Inflammation causes a falsely ___ ferritin

Answer 15

elevated

Question 16

A visual qualitative assessment of tissue iron stores

Answer 16

Prussian blue staining

Question 17

Gold standard for assessment of body iron stores

Answer 17

Prussian blue staining

Question 18

Specimen of choice for prussian blue staining

Answer 18

bone marrow and liver biopsies

Question 19

A sensitive marker to diagnose iron deficiency anemia

Answer 19

Soluble transferrin receptor

Question 20

Differentiates anemia of chronic inflammation and and iron deficiency anemia with chronic inflammation

Answer 20

Soluble transferrin receptor log ferritin ratio index

Question 21

When intracellular iron drops, the cell expresses ___ on the membrane

Answer 21

transferrin receptor (TfR)

Question 22

Reflects the status of erythropoiesis in the 24-hour period

Answer 22

Hemoglobin of reticulocytes (MCH)

Question 23

Provides a real-time assessment of iron available for hemoglobin production

Answer 23

Hemoglobin of reticulocytes (MCH)

Question 24

Identify the anemia:

High serum iron
High ferritin
Low TIBC
High % saturation

Answer 24

Sideroblastic anemia

Question 25

Identify the anemia: Low stored iron Low ferritin High TIBC Low % saturation High sTFR (-) Prussian blue staining

Answer 25

Iron deficiency anemia

Question 26

Identify the anemia: High serum iron High ferritin Low TIBC High % saturation Normal sTFR (+) Prussian blue staining

Answer 26

Hemochromatosis

Question 27

Identify the anemia: High stored iron High/normal ferritin Low TIBC Low % saturation Normal sTFR (+) Prussian blue staining

Answer 27

Anemia of chronic inflammation

Question 28

This reduces ferric to ferrous ion

Answer 28

Duodenal cytochrome b

Question 29

Transports ferrous ion inside the enterocyte

Answer 29

Divalent metal transporter 1

Question 30

Heme is transported to enterocyte through ___

Answer 30

heme transporter

Question 31

This releases iron from protoporphyrin IX to be absorbed by the enterocyte

Answer 31

Heme oxygenase 1

Question 32

Stored iron

Answer 32

Ferritin

Question 33

Transports iron out from enterocyte to circulation

Answer 33

Ferroportin

Question 34

Regulates iron homeostasis

Answer 34

Hepcidin

Question 35

Reoxidizes ferrous to ferric ion to bind with transferrin

Answer 35

Hephaestin