Zofran (Ondansetron)

Question 1

Zofran (Ondansetron) class

Answer 1

Antiemetic (5HT3 Serotonin receptor antagonist)

Question 2

Zofran (Ondansetron) MOA

Answer 2

Normally serotonin release in small intestine stimulates vagal afferents through 5HT3 receptor initiating vomiting

Zofran block receptors preventing N/V, but does NOT treat N/V caused by vestibular stimulation

Question 3

Zofran (Ondansetron) dosage

Answer 3

4-8 mg IV 2-5 before induction and after procedure

Question 4

Zofran (Ondansetron) characteristics

Answer 4

O: 30-60 min

P: 1-1.5 hrs

D: 4-6 hrs

Question 5

Zofran (Ondansetron) E/M

Answer 5

M: CYP 450

E: renal

H/t: 3-4 hrs

Question 6

Zofran (Ondansetron) considerations

Answer 6

Prolonged QT

Serotonin syndrome w/ SSRIs & SNRIs

C/I: cardiac pt w/ high magnesium bc can prolong QT causing torsades