Sugammadex (Bridion)

Question 1

Sugammadex (Bridion) class

Answer 1

Selective relaxing binding agent

Selective NMB reversal agent

Question 2

Sugammadex (Bridion) MOA

Answer 2

Forms tight 1:1 complex w/ steroidal NMB agents (Roc, Vec, Panc)
Encapsulation so can reverse any depth of block

Best on Roc> Vec > Panc

Question 3

Sugammadex (Bridion) dosage

Answer 3

TOF 2/4: 2mg/kg

TOF 1/4/Deep blocks/post-tetanic twitches present: 4mg/kg

8-16mg/kg for emergent rapid reversal

Question 4

Sugammadex (Bridion) characteristics

Answer 4

O: 1-3 min

P: 3 min

D: 15 min- 2 hrs? Can stay in system for 24 hrs making next does of NMBA less effective

Question 5

Sugammadex (Bridion) E/M

Answer 5

75% renal

Question 6

Sugammadex (Bridion) considerations

Answer 6

Inhibits oral contraceptives- tell pts to use non hormonal method for 7 days

Can cause anaphylaxis, arrythmias, brady, asystole

C/I: creatinine clearance <30ml/min, ESRD