Esmolol (Breviblock)

Question 1

Esmolol (Brevibloc) classification

Answer 1

Cardioselective beta-1 adrenergic receptor antagonist

Question 2

Esmolol (Brevibloc) MOA

Answer 2

Competitive antagonist for beta-1 receptors

Question 3

Esmolol (Brevibloc) dosage

Answer 3

Int: 0.5-1mg/kg 2 min before
(150 mg 2 min before DL)

Loading: 500 mcg/kg
Inf: 100-300 mcg/kg/min

Question 4

Esmolol (Brevibloc) characteristics

Answer 4

O: 2 min

P: 5 min

D: 10-15 min

Question 5

Esmolol (Brevibloc) E/M

Answer 5

Rapid hydrolysis by plasma esterases independent of renal & hepatic fxn

Question 6

Esmolol (Brevibloc) considerations

Answer 6

Poor lipid solubility limits transfer to CNS or placenta

C/I: asthma, brady, acute HF, HB