Metoprolol (Lopressor, Toprol XL)

Question 1

Metoprolol (Lopressor, Toprol XL) class

Answer 1

Selective Beta-1 adrenergic receptor blocker (cardioselective)

Question 2

Metoprolol (Lopressor, Toprol XL) MOA

Answer 2

Prevents inotropic & chronotropic responses to Beta stimulation

Question 3

Metoprolol (Lopressor, Toprol XL) dosage

Answer 3

IV: 1-15mg

PO: 50-400mg (tartrate), 50-150mg (succ)

Question 4

Metoprolol (Lopressor, Toprol XL) characteristics

Answer 4

O: 1-5 min

P: 20 min

D: 5-7 hrs

Question 5

Metoprolol (Lopressor, Toprol XL) E/M

Answer 5

M: Hepatic first-pass, only 40% makes it to systemic circulation

H/t: IV 3-7 hrs
Tart: 2-3 hrs
Succ: 5-7 hrs

Question 6

Metoprolol (Lopressor, Toprol XL) considerations

Answer 6

Caution w. High doses in chronic obstructive airway & hypoglycemic

C/I: AV HB, acute HF not caused by tachycardia, hypovolemic w/ compensatory tachycardia (can cause resistant hypotension)