Yersina pestis

Question 1

Yersina pestis have ______ pili
And why are they so COOL!?
What is this pili made of?

Answer 1

F1
-produced at 37degC
Caf1 fibres-allow variation

Question 2

Yersina (all) use __________ adhesion which comes from __________, secreted by _____

Answer 2

Afimbral
YadA
T5SS

Question 3

YadA in Yersina pestis binds

Answer 3

Collagen (ECM of host)

-is tep dependant

Question 4

YadA secreted by _______

Answer 4

T5SS

-

Question 5

Invasin is an __________incoded by ________gene

Answer 5

Adhesin

Invasin gene

Question 6

Invasin and _________allows ________

Answer 6

B integrity (host)
Endocytosis

Question 7

Invasin ________ to enclose yersina

Answer 7

Zippers

Question 8

Yersina pestis escapes immune sys by?

Answer 8

Lipid A modification (evades TLR)

• tetra-acetylation Lipid A in flea
• hexa-acetylation Lipid A in human
• due to temp change

Question 9

Yops?

Answer 9

-from T3SS
-injected into host
-neutralized immune sys by:
-filament depolymerization
-inhibit local adhesin kinases from triggering cell-cell commun.
Actin surrounds vessicle with pathogen and protects the
pathogen