Toxins

Question 1

DT is what type of toxin
Which means it is
_______

Answer 1

A-B

Secreted separately but associate during secretion

Question 2

Phases in code

Answer 2

DT and CT toxins

Question 3

DT mode of action

Answer 3

ADP ribosylates EF2 elongation factor

Question 4

DT gets into host via______

Binds ______

Answer 4

RME

Hepran binding EGF receptors (Hp-EGF)

Question 5

DT b unit

Answer 5

Forms pore in endosome after having SS bond with A unit broken due to endosome acidity.

Question 6

PT binds

Answer 6

Sialogycoproteins in host receptor cells

Question 7

PT method of entry

Answer 7

REM

Question 8

PT goes where in cell

Answer 8

Retrograded to ER lumen - B-stays

A-binds ATP - enters cytoplasm

Question 9

A subunit it PT does?

Answer 9

ADP- ribosylates G-protein

=anti-inflammatory response

Question 10

CT goes where in cell? Because of a ________ sequence

Answer 10

Retrograde transport to ER

KDEL sequence in B-subunit

Question 11

__________ unfolds PT A subunit and allows _______

Answer 11

PDI =protein disunited isomerase

Export

Question 12

CT binds

Answer 12

GM1 -in gut

Question 13

CT ___________ while PT _____________

Answer 13

Increases cAMP

Decreases cAMP

Question 14

CT secreted by

Answer 14

T3SS- piston like

Question 15

T3SS secretes CT and _________ which __________

Answer 15

Neuroamidase

Removes italic acid from host cell reception M1 so CT can bind