Year 2 Flashcards
most common glomerulonephritis in children, what is the physiological change?
minimal change
fusion of the podocytes
most common glomerulonephritis in adults
focal segmental
most common glomerulonephritis in the UK
membranous
most common glomerulonephritis in the world
IgA (related to HSP)
what glomerulonephritis has ANCA subtypes
rapidly progressive
define nephrotic syndrome
oedema, proteinuria >3g/day, hypoalbuminaemia
level 1 CKD
> 90ml/min
level 2 CKD
60-90
level 3a CKD
45-59
level 3b CKD
30-44
level 4 CKD
15-29
most common renal stone
calcium oxalate
what is reabsorbed at the proximal convoluted tubule
sugar, amino acids, phosphate, sulphur and lactate
what is secreted at the proximal convoluted tubule
H+
what is absorbed in the loop of henle
Sodium, chlorine (ascending part)
water (descending part)
what is absorbed in the distal convoluted tubule
NaCL, Ca, Na, K
uncomplicated UTI in F
trimethoprim/nitrofurantoin (3 days)
uncatheterised male, UTI treatment
trimethoprim/nitrofurantoin (7 days)
pregnancy UTI treatment
1st/2nd trimester - nitrofurantoin
3rd trimester - trimethoprim
All through pregnancy - cefalexin
diagnosis of diabetes
symptomatic; fasting>7, random>11
asymptomatic; same criteria on two occasions
screening test for acromegaly
IGF-1
diagnostic test for acromegaly
oral glucose tolerance
tests for addison
short synacthen, anti-21 hydroxyls, 9am cortisol
blood results in conns
excess aldosterone, increased NaCl, decreased K
test for adrenal hyperplasia
aldosterone to renin ratio
saline suppression test
test for cushings
low dose dexamethasone
24h urinary cortisol
antibodies in hashimotos
anti-Tg
test for phaechromocytoma
urinary catecholamines, 131 iodine MIBG
pituitary hormones; anterior
GH, ACTH, TSH, PRL, FSH, LH
pituitary hormones; posterior
oxytocin, ADH
hypothalamic hormones; inhibiting
somatostatin, dopamine
hypothalamic hormones; releasing
GHRH, PRH, TRH, CRH, GnRH
rapid acting insulin
humalog, novorapid, apidra
short acting insulin
humulin S, Actarapid, Insuman
intermediate insulin
Insulatard, Humulin I, insuman
long acting insulin
lantus, levemir
diabetes drugs; weight loss
metformin, incretins, SGLT2
diabetes drugs; weight gain
sulphonylureas, TZDs
diabetes drugs; weight neutral
DDP4s
diabetes drugs; prevent macrovascular complications
TZDs
diabetes drugs; prevent microvascular complications
sulphonylureas
what conditions make up MEN 1, what gene is at fault
parathyroid, pituitary, pancreas
MEN1
what conditions make up MEN2a, what gene is at fault
thyroid, parathyroid and pheochromocytoma
RET oncogene
what conditions make up MEN2b, what gene is at fault
medullary thyroid, phaeochromocytoma