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SAMS 2 exam 3 wound and skin stuff > Wounds and wound healing > Flashcards

Wounds and wound healing Flashcards

1
Q

cutaneous blood supply is the direct vessel supply to the skin without musculocutaneous vessels T/F

A

True

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2
Q

Is the cutaneous blood supply mobile?

A

yes (cutaneous trunci and platysma)

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3
Q

What are the 3 plexi of blood supply to the skin?

A

Subdermal (deep), cutaneous (middle), subpapillary (superficial)
noooo bf in the top layer of skin

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4
Q

Phases of wound healing:

A

Inflammatory, proliferative, remodeling

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5
Q

When does the inflammatory process of wound healing begin? When does it end?

A

begins IN SECONDS must end by 7 days (any time after 7 days is not normal)

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6
Q

___ phase is responsible for the four cardinal signs of inflammation

A

Inflammatory phase

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7
Q

____ phase is when granulation tissue is formed as fibroblasts proliferate and secrete collagen, contraction of wound edges and re-epithelization over new granulation tissues

A

proliferative

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8
Q

Proliferative phase begins how long after wound

A

starts in 2-5 days

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9
Q

What is the lag phase of wound healing aka the weakest point in wound healing?

A

The proliferative phase

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10
Q

*Fibroplasia and angiogenesis =

A

GRANULATION TISSUE*

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11
Q

*______ + _____= granulation tissues

A

Fibroplasia and angiogenesis (occurs in the proliferative stage of wound healing)

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12
Q

____ is the fragmentation of the basement membrane- migration of the endothelial cells- proliferation- capillary and capillary tube formation

A

Angiogenesis

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13
Q

Granulation tissue appears __-__ days after injury

A

3-5 days

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14
Q

What is epithelization?

A

detachment of basilar keratinocytes for migration and differentiation, starts at inflammatory phase (scarring)

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15
Q

Must develop _______ tissue before ______

A

granulation tissue before epithelialization

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16
Q

What is wound contracture?

A

contraction of a wound causes distortion of an adjacent orifice or joint, NOT DESIRABLE, abnormal

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17
Q

What is wound contraction???

A

myofibroblasts, occurs when wound edges meet or tension of surrounding skin equals or secedes the force of contraction

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18
Q

Contraction is normal unlike ___

A

contracture

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19
Q

_____ occurs over weeks to months and involves granulation tissue that is replaced by mature connective tissues/collagen/scars

A

remodeling

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20
Q

The final stage of remodeling can take months to two years, what occurs during this time?

A

decreased cell count and vasculature to make a scar, reaches max of 80% of original tensile strength of skin

(Reaches 100% tensile strength in bladders and bones!)

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21
Q

___ is a subset of the remodeling phase where granulation tissue is replaced with mature CT, fibronectin and type 3 collagen are replaced by type 1 collagen and creates basket weave bundles lying parallel to the wound

A

Maturation phase

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22
Q

What are factors affecting healing?

A

host, wound characteristics, wound depth, and time in sx

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23
Q

Infection is ______ organisms per gram of tissue

A

> 10^5

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24
Q

Partial thickness-

A

shallow wounds, involve epidermal loss and partial loss of dermis

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25
Full thickness-
total loss of epidermis and dermis, extending to subQ with possibly into deep fascia, muscles, and/or bone
26
Which bite wounds must be tx aggressively?
1. BDLD where big dog picks up and shakes little dog 2. Location of wounds (ex: chest or airways or abdomen) 3. Clinical assessment of severity of trauma
27
Anatomic vs physiologic degloving-->
anatomical is tissues completely gone | physiologic degloving is tissues still present but bf damaged so sloughed
28
Thermal burns are classified based on ___ and _____ involved
depth and percentage involved
29
What is the most common secondary infection of a thermal wound/ burn or frostbite?
Pseudomonas
30
Are burns proportional to pain??
No
31
What are the 6 basic steps of wound care???
1. prevent further wound contamination 2. debride the dead and dying tissues 3. remove the foreign debris and contaminants 4. provide ideal wound environment 5. promote a viable vascular bed 6. select appropriate closure
32
about up to 90% of bacteria and debris can be removed out of a wound with what technique?
Warm sterile saline used for wound lavage (or can use balanced electrolyte like LRS) 7-8 psi pressure desired which is 35 or 60mL syringe with 18 gauge needled pushed as hard as possible
33
Culture before or after lavage?
After
34
What are the most common lavage solutions?
LRS or 0.9% saline LRS is least cytotoxic- more balanced Saline is more hypertonic
35
Why do we usually not use plain water for lavage?
Hypotonic solutions burst cells which makes it cytotoxic by definition and can delay healing
36
What are the methods for wound debridement?
Surgical, enzymatic, chemical, mechanical
37
How can we do sx debridement of wounds?
Layered- most common or you can incise around it and remove. "En Bloc"
38
What is the mechanism of most topical wound medications?
most work by modulating macrophage functions BUT CAN DELAY WOUND HEALING OR CAUSE RESISTANT INFECTIONS
39
Under what circumstances can we use primary (first intention) closure?
clean wounds <6 hours old and bacteria <10^5 CFU/g tissue, DO NOTTT close bite puncture wounds
40
What is it called when we convert to clean wound and close before granulation (1-3 days)
Delayed primary
41
What is involved with secondary healing of a wound?
initial treatment as open wound, formation of health granulation bed, closure of wound after development of healthy granulation tissue (min. of 3-5 days), suture wound edges (primary closure) and flaps, grafts with secondary closure
42
What is involved with SECONDARY INTENTION wound healing?
allow to heal on its own, avoid over high motion areas, may not heal completely, watch for contracture, can take up to 5 days for vitalized tissues to arrive
43
What is the golden rule for decision making of wound healing?
Golden rule is NO TIME PERIOD FOR CLOSURE, BUT NUMBER OF BACTERIA MATTER <10^5 ORGANISMS/GRAM TISSUE OR NO GROSS CONTAMINATION
44
All drains increase risk of infection and must be protected with bandage/sterile cover. T/F
True!!!
45
What is an example of a passive drain? What does it involve?
Penrose drain | fluid drain around and not through, depends on gravity, REQUIRES STERILE COVERING
46
What is an example of an active drain. What does it involve?
JP drain, depends on vacuum, drains out deeper structures, works better than passive drains, lower risk of infection but obstruction is the main concern, empty reservoir every four hours or when half full
47
what are the rules for drain placement?
Make a separate stab incision for the drain, do NOT exit the drains through the initial wound/incision, drain should not lie directly under the suture line, secure the drain to the skin, do NOT tack in place with buried sutures, COVER ALL DRAINS!!!
48
Drain removal- when to know when to remove?
Remove if: - discharge becomes transudate - when draining decreases to like 1-2 ml/kg/day - removal is usually in 3-7 days but most impt is to look at when draining decreases to gauge when to remove it
49
Main bulk of healing is the ____ phase
proliferative
50
What 4 goals are involved with proliferative phase?
Fibroplasia, angiogenesis, epithelialization, contraction
51
____ put down collagen and ECM
Fibroblasts
52
capillary tube formation =
angiogenesis
53
? is resistent to infection and acts as a biological band aid to the wound
Granulation tissue
54
How long does it take for a sutured wound to have epithelialization?
1-2 days
55
When does contraction occur?
5-9 days after injury
56
define clean wound
surgically created, no hollow viscous organ entered, aseptic without infections
57
define clean contaminated wound
surgical wounds that enter hollow viscous organ or minor break in aseptic technique (hole in glove)
58
Contaminated wounds
operative wounds with major break in technique, hollow viscous organ opened with gross spillage or traumatic wounds
59
Dirty wound definition
purulent exudate, or contents of perforated hollow viscous organ, infected, more than 10^5 orgs per gram of tissue
60
What is the most common source of surgical infection?
Endogenous flora- bacterial residents to the areas in or adjacent to the site
61
with burns were are mostly worried about what 3 things?
Loss of albumin, metabolic derangements, dehydration
62
examples of chemical debridement
trypsin, castor oil, Balsam of Peru
63
examples of mechanical debridement
dry to dry or wet to dry bandages
64
A sharp laceration with soil in it that is 2 hrs old needs that closure?
delayed primary | open wound management for 1-2 days then close
65
degloving injury with exposed tendons and bone with road debris would need what type of wound healing?
Secondary closure
66
Ascending infection is greater with what type of drains?
active drains
67
Infection rates ___ for every hour in surgery and increase __% per every anesth hour
double; 30%
68
Conc of iodine to flush wounds vs chlorhex
Iodine 1% | Chlorhex 0.05%
69
Where should we NOT use healing by secondary intention methods?
High motion areas
70
methicillin/oxacillin resistant staph
- staph with mecA gene | - allows for resistance to penicillin and Beta lactams
71
which antibiotic has poor bioavailability in the dog for treating bacterial pyoderma
Ciprofloxacin
72
What is adnexal healing?
- similar to second intention - used with partial thickness wounds - hair follicles are the source of epithelial cells for wound healing - healing from the inside and outward

SAMS 2 exam 3 wound and skin stuff (12 decks)

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