Wounds and Inflammation

Question 1

What are the characteristics of Inflammation?

Answer 1

• Rubur (redness)
• dolor (pain)
• calor (heat)
• tumor (swelling)
• functio laesa (loss of function)

Question 2

What is the vascular component of an inflammation?

Answer 2

Vascular component:

• The vascular permeability raises
• Vasodilation
• Endothelial injury

Question 3

What is the cellular component of an inflammation?

Answer 3

Neutrophils extravasate from circulation to injured tissue to participate (teilnehmen) in inflammation through phagocytosis, degranulation, and inflammatory mediator release

Question 4

Describr the acutr inflammation!

Answer 4

Akute:
Neutrophil, eosinophil, and antibody mediated.
Acute inflammation is rapid onset (Ausbruch, Beginn) - seconds
to minutes and lasts minutes to days

Outcome include complete resolution (Bewältigung) , abscess formation, and Progression (Entwicklung) to chronic inflammation

Question 5

Describe chronic inflammation!

Answer 5

Mononuclear cell mediated:
Characterized by persistent destruction and repair.

Associated with blood vessel proliferation, fibrosis

Granuloma:
- nodular collections of epithelioid macrophages and giant cells

Outcome include scarring and amyloidosis

Question 6

What means atrophy? What are the reasons of atrophy (6)?

Answer 6

Atrophy: reduction in the size or number of cells

Causes include:

• blood flow -down
• hormones vagina/uterus -down
• innervation -down (motor neuron damage)
• nutrients -down
• pressure +high (nephrolithiasis)
• occlusion (Verstopfung) of secretory ducts (cystic fibrosis)