Wound Healing Review Flashcards
Phases
Inflammatory
Proliferation
Remodeling
Phases - inflammatory
injury to 4 days
Phases - proliferation
4 to 21 days
Phases - remodeling
21 days to 2 years
Phases - inflammatory phase consists of what
Hemostasis
Active inflammation
Degradation
Phases - inflammatory phase - Hemostasis
Patelets
Chemotaxis
Fibrin
Phases - inflammatory phase - Active inflammation
Neutrophils
Plasma proteins
Mast cells
Phases - inflammatory phase - Degradation
Macrophages
Collagenese
Nitric oxide release
Keratinocyte activation
Phases - proliferation/granulation phase - parts
Angiogenesis
Granulation
Wound contraction
Epitheliazation
Phases - proliferation/granulation phase - Angiogenesis
New BVs form
Stimulated by various growth factors released by endothelial cells and keratinocytes
Lymph vessels begin to function again
Phases - proliferation/granulation phase - Granulation
ECM is developed
Fibroblasts
Phases - proliferation/granulation phase - wound contraction
Myofibroblasts (actin rich)
Found in dermal layer
Phases - proliferation/granulation phase - Epithelialization
Keratinocyte migrate across wound
Growth factors are a major activation for this process
Phases - Remodeling/maturation phase
Type III collagen is converted to Type I
Dec vascular supply
Wound begins to strengthen and conform to stress lines
Not the same tissue thoguh!
Primary intention healing
Wound edges are approximated
Heals viz mostly an epithelization process
Ex - suture, when you cut yourself with knife