Wound Healing Review Flashcards

1
Q

Phases

A

Inflammatory
Proliferation
Remodeling

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2
Q

Phases - inflammatory

A

injury to 4 days

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3
Q

Phases - proliferation

A

4 to 21 days

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4
Q

Phases - remodeling

A

21 days to 2 years

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5
Q

Phases - inflammatory phase consists of what

A

Hemostasis
Active inflammation
Degradation

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6
Q

Phases - inflammatory phase - Hemostasis

A

Patelets
Chemotaxis
Fibrin

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7
Q

Phases - inflammatory phase - Active inflammation

A

Neutrophils
Plasma proteins
Mast cells

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8
Q

Phases - inflammatory phase - Degradation

A

Macrophages
Collagenese
Nitric oxide release
Keratinocyte activation

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9
Q

Phases - proliferation/granulation phase - parts

A

Angiogenesis
Granulation
Wound contraction
Epitheliazation

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10
Q

Phases - proliferation/granulation phase - Angiogenesis

A

New BVs form
Stimulated by various growth factors released by endothelial cells and keratinocytes
Lymph vessels begin to function again

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11
Q

Phases - proliferation/granulation phase - Granulation

A

ECM is developed

Fibroblasts

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12
Q

Phases - proliferation/granulation phase - wound contraction

A

Myofibroblasts (actin rich)

Found in dermal layer

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13
Q

Phases - proliferation/granulation phase - Epithelialization

A

Keratinocyte migrate across wound

Growth factors are a major activation for this process

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14
Q

Phases - Remodeling/maturation phase

A

Type III collagen is converted to Type I
Dec vascular supply
Wound begins to strengthen and conform to stress lines
Not the same tissue thoguh!

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15
Q

Primary intention healing

A

Wound edges are approximated
Heals viz mostly an epithelization process
Ex - suture, when you cut yourself with knife

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16
Q

Secondary intention healing

A

Substantial tissue loss involving the dermis
Wound edges can not be approximated
Heals via full granulation
Scar formation

17
Q

Delayed primary cloasure

A

Some wounds need to be left opn secondary being dirty

Left oen until determined to be clean and then is surgically closed

18
Q

Characteristics of the wound that can impact healing

A
Mechanism
Location
Size
Temperature
Necrotic Tissue
Infection
CHronic vs. Acute
19
Q

Local factors impacting healing

A

Blood flow
Mechanical stress
Tissue condition
Sensation

20
Q

Systemic factors impacting healing

A
Nutrition status
Meducation use
Age
Co morbidities
Bx risk issues