Women's Health (things I forget) Flashcards
Describe HELLP syndrome
- Severe form of pre-eclampsia
- (H)aemolysis, (E)levated (L)iver enzymes, (L)ow (P)latelets
- Malaise/nausea/vomiting/headache
- HTN with proteinuria
- Epigastric/upper abdominal pain
What is Sheehan syndrome?
Hypopituitarism caused by ischaemic necrosis due to blood loss and hypovolaemic shock
- Agalactorrhoea
- Amenorrhoea
- Sx of hypothyroidism
- Sx of hypoadrenalism
What is Asherman’s syndrome?
Intrauterine adhesions that commonly occur following dilation and curettage
- Secondary amenorrhoea
- Significantly lighter periods
- Dysmenorrhoea
What are risk factors for endometrial hyperplasia?
- Unopposed oestrogen
- Tamoxifen (selective oestrogen receptor modulator)
- Obesity
- Early menarche/late menopause
- Age >35
- Smoking
- Nulliparity
- Sex cord stromal tumours (granulosa cell tumours/sertoli cell tumours/thecomas/fibromas)
What are the clinical features of endometrial hyperplasia?
Abnormal bleeding = intermenstrual/post-menopausal/menorrhagia/irregular
What is the management for endometrial hyperplasia?
- Simple = high dose progestogens (e.g. IUS)
- Hysterectomy
What is the most common cause of post-menopausal bleeding?
Vaginal atrophy
What are the investigations for post-menopausal bleeding?
- Transvaginal USS
- Pipelle biopsy
- Hysteroscopy with biopsy
What is cervical ectropion?
Increased columnar epithelium on ectocervix due to elevated oestrogen levels
- Vaginal discharge
- Post-coital bleeding (most common cause)
- Inter-menstrual bleeding
What is the most common cause of pyrexia in pregnancy?
Chorioamnionitis - usually the result of an ascending bacterial infection of amniotic fluid/membranes/placenta –> P-PROM
What is the management for chorioamnionitis?
- Emergency delivery
- IV abx
What increased risk is there when taking HRT + a progestogen?
Breast cancer
What is lochia and how does it present?
- Bleeding present for first 2 weeks following giving birth
- Fresh bleeding –> colour change (brown) –> stops
What is the main complication of induction of labour and how is it managed?
- Uterine hyperstimulation
- Administer tocolytic agents to relax uterus/slow contractions
What is the first-line method of inducing labour?
Vaginal prostaglandins
What are some causes of an increased nuchal translucency?
- Down’s syndrome
- Congenital heart defects
- Abdominal wall defects
What findings of the combined test would suggest a high risk of Down’s syndrome?
- Thickened nuchal translucency
- High beta-hCG
- Low PAPP-A
What findings of the quadruple test would suggest a high risk of Down’s syndrome?
- High hCG
- High inhibin A
- Low AFP
- Low oestriol
What findings of the quadruple test would suggest a high risk of Edward’s syndrome?
- Low hCG
- Low oestriol
- Low AFP
- Normal inhibin A
What findings of the quadruple test would suggest a high risk of neural tube defects?
- High AFP
- Normal hCG
- Normal inhibin A
- Normal oestriol
What should be given to patients at moderate/high risk of pre-eclampsia?
Low-dose aspirin (75-150mg) daily for duration of pregnancy
What is the management for eclampsia?
Magnesium sulphate (prophylaxis and treatment) = continue for 24 hours after delivery/last seizure
What is the order of management for gestational HTN?
- Labetalol (beta blockers) - first line
- Nifedipine (CCB) - if asthma
- Methyldopa - contraindicated in depression
Admit if >160/110
What is the management for hyperemesis gravidarum?
- Antihistamines - promethazine
- IV saline + potassium
- Ondansetron (risk of cleft lip/palate in first trimester)
- Metoclopramide/domperidone (extra-pyramidal side effects)
What is a threatened miscarriage?
- NOT A MISCARRIAGE
- Bleeding +/- pain
- Before 24 weeks
- Cervical os closed
- Fetus alive
What is a missed (delayed) miscarriage?
- Gestational sac contains dead fetus before 20 weeks without symptoms of expulsion
- Light vaginal bleeding/discharge
- Symptoms of pregnancy disappear
- Cervical os closed
What is the difference between an inevitable miscarriage and an incomplete miscarriage?
Inevitable:
- Heavy bleeding with clots
- Pain
- Cervical os open
- Possible foetus with heartbeat
Incomplete:
- Bleeding
- Pain
- Cervical os open
- Products of conception
What is a complete miscarriage?
- No cardiac activity
- Crown rump length >7mm
- Gestational sac >25mm
- Cervical os closed
What is the management for miscarriages?
- Missed = oral mifepristone + misoprostol 48 hours later
- Incomplete = single dose of misoprostol
IF EVIDENCE OF INFECTION/HAEMODYNAMIC INSTABILITY:
- Surgery = vacuum aspiration (suction curettage)
What is the management for ectopic pregnancies?
- Expectant management = monitor b-hCG levels over 48 hours
- Medical = methotrexate
- Surgical = salpingectomy/salpingotomy
What are the clinical features of uterine fibroids?
- Menorrhagia
- Anaemia
- Bulk-related symptoms e.g. bloating/urinary frequency
Describe uterine fibroids in pregnancy
- Sensitive to oestrogen –> can grow during pregnancy
- May undergo red or ‘carneous’ degeneration if growth outstrips blood supply
What is the management for fibroids?
- IUS/COCP/tranexamic acid = if <3 cm and not distorting uterine cavity
- GnRH agonists = shrink (induce menopausal-like state)
- Surgery = myomectomy
What are the investigations for PCOS?
- Pelvic USS
- LH + FSH
- Prolactin
- TSH
- Testosterone
- Sex hormone-binding globulin
Describe stereotypical PCOS findings
- raised LH:FSH ratio (raised LH)
- Testosterone normal/mildly elevated
- Serum sex hormone binding globulin (SHBG) normal/low
What criteria is used for PCOS?
Rotterdam criteria - 2 of 3 features:
- Oligomenorrhoea/amenorrhoea (oligoovulation/anovulation)
- Clinical/biochemical signs of hyperandrogenism (hirsutism/acne/elevated testosterone)
- Polycystic ovaries on USS (either >12 follicles or increased ovarian volume >10cm3)
What is the management for PCOS?
- Oligomenorrhoea/hirsutism/acne = COCP/oral progestogen/IUS
- Infertility = referral/clomifene citrate/metformin
How does metformin help in PCOS?
- Appetite reduction
- Decreases androgen production
- Decreases LH secretion from anterior pituitary
- Decreases SHBG in liver
Describe perineal tears
First degree:
- Superficial/no muscle involvement
- No repair required
Second degree:
- Injury to perineal muscle but not anal sphincter
- Suture on ward
Third degree:
- Injury to perineum involving anal sphincter complex
- Repair in theatre
Fourth degree:
- Injury to perineum involving anal sphincter complex and rectal mucosa
- Repair in theatre
What should be given to all patients with PPROM?
10 days oral erythromycin and antenatal corticosteroids
Describe placenta accrete spectrum
Placenta accreta = myometrium
Placenta increta = deep myometrium
Placenta percrata = past myometrium and perimetrium
What are the investigations for obstetric cholestasis?
- LFTs
- Bile acids
What is the management for intrahepatic cholestasis?
- Induction of labour at 37-38 weeks (to avoid risk of stillbirth)
- Ursodeoxycholic acid
- Chlorphenamine and aqueous cream
- Vitamin K supplementation
- Antihistamines
What is the first line emergency contraception?
Copper IUD
- Must be inserted within 5 days of UPSI
OR - May be fitted up to 5 days after likely ovulation date
Describe the hormonal forms of emergency contraception
Levonorgestrel:
- Must be taken within 72 hours of UPSI
- Single dose (doubled if BMI >26/weight >70kg/enzyme-inducing drugs)
- Repeat dose if vomiting within 3 hours
- Hormonal contraception can be started immediately after
- No effect on breastfeeding
Ulipristal:
- Must be taken within 120 hours (5 days) of UPSI
- Hormonal contraception started 5 days after
- Breastfeeding should be delayed for one week
What are some contraindications for prescribing ulipristal acetate?
- Diseases of malabsorption e.g. crohns
- Allergy
- Asthma
- Breastfeeding
- Severe hepatic dysfunction
What is the guidance for folic acid?
- All women = 400mcg of folic acid until 12th week
- Higher risk = 5mg of folic acid from before conception until 12th week
^ higher risk = taking antiepileptic drugs/coeliac/diabetes/thalassaemia/obesity/neural tube defects
What are the basic investigations for infertility?
- Semen analysis
- Serum progesterone 7 days prior to expected next period
What is the management for infertility due to ovulation disorders?
- Exercise/weight loss
- Letrozole
- Clomifene citrate
- GnRH therapy
What is a complication of ovulation induction?
Ovarian hyperstimulation syndrome - ovarian enlargement and formation of multiple cystic spaces
- Hypovolaemic shock
- Acute renal failure
- VTE
What are the investigations for endometriosis?
- Vaginal examination = fixed retroverted uterus/tender uterus/visible vaginal endometriotic lesions
- Laparoscopy + biopsy = gold standard