Wk 9.2 Parkinsons's Disease

Question 1

What are the clinical features of PD?

Answer 1

-Motor symptoms
-Elderly ppl (65 and up)
- Aggressive onset variant from 35yrs
- Tremors at rest
- Muscle ridigity

Question 2

What is included in the time course for PD?

Answer 2

-50-60% dopaminergic neuron loss

Question 3

What is the functuon of the basal ganglia?

Answer 3

-Sequencing movements
-Selection of movements

Question 4

When are PD symptoms apparent?

Answer 4

When 70-80% of cells are 50% starital terminals are lost

Question 5

What are the environmental risk factors?

Answer 5

-Prior exposure to toxin
- Possible link to gut microbiome

Question 6

What does low levels of dopamine cause

Answer 6

1. SN and Straium degration= increase in GABA decrease in Dopamine
2. low levels of dopamine = increase production of acetylcholine leading to impaired mobility
3. Leading to tremors and ridigity

Question 7

How does Dopamine work in the system

Answer 7

1. Dopamine is synthesised in two steps 1. trysone
2. Dopamine is release to post synpatic and reuptaked by glial to mao and comt
3. MAO are found in the glial cells

Question 8

What does Levedopa do

Answer 8

1. Precursor of Dopamine is used due to the BBB- the molecules can pass through with the levedopsa but not dopamine
2. Levadopa has two problems in the PNS as there are two enzymes that breakdown levedopa before reaching the brain
3. PDC convert levodopa to dopa and COMT Levodopa to 3OMD
4. Levodopa is administered with another agent carbidopa which inhibits dopa decarboxylase reducing the metablism of levodopa
5. Entacapone inhits COMT prolobng time levodopa is avaible to the brain
6. Levodopa to dopamine in the brain