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Chem 1 > Wk 8 quiz, Wk 9 quiz, Exam 3 review bingo > Flashcards

Wk 8 quiz, Wk 9 quiz, Exam 3 review bingo Flashcards

1
Q

Which of the following statements is NOT true concerning testing for drugs of abuse?

-A two-tired testing approach includes screening and confirmatory testing
-Confirmatory testing must use methods with high specificity and low sensitivity
-Screening tests detect classes of drugs
-GC-MS is the reference method used for confirmation

A

Confirmatory testing must use methods with high specificity and low sensitivity

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2
Q

Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.

-True
-False

A

True

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3
Q

Which of the following is NOT true concerning analysis of toxic agents?

-Screening tests have good specificity but lack sensitivity
-Confirmatory tests report the concentration of the analyte
-Screening tests are a rapid test intended to detect the presence of a substance
-The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS)

A

Screening tests have good specificity but lack sensitivity

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4
Q

Toxic levels of acetaminophen are associated with:

-Ototoxicity
-Nephrotoxicity
-Hepatotoxicity
-Neurotoxicity

A

Hepatotoxicity

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5
Q

Pharmacokinetics and drug concentration are influenced by which of the following factors?

-Absorption, distribution, excretion, metabolism
-Absorption, bioavailability, excretion, metabolism
-Biotransformation, distribution, excretion, metabolism
-Adaption, distribution, excretion, metabolism

A

Absorption, distribution, excretion, metabolism

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6
Q

A drug’s most direct and effective method of delivery to its site of action is:

-Oral administration
-Intramuscular injection
-Intravenous administration
-Aerosol ingestion

A

Intravenous administration

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7
Q

A blood draw to determine a peak level of a drug should be drawn:

-One hour after an orally administered dose
-Immediately after drug administration
-90 minutes after an orally administered dose
-Immediately before drug administration

A

One hour after an orally administered dose

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8
Q

Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.

-True
-False

A

True

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9
Q

The major transporter of drugs

A

Albumin

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10
Q

The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system

A

First Pass Effect

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11
Q

The study of the biochemical and physiological effects of drugs and their mechanisms of actions

A

Pharmacodynamics

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12
Q

This tumor marker often is measured in both the total and free form

A

PSA

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13
Q

The concentration range of a drug within which the drug produces the desired effect

A

Therapeutic Range

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14
Q

This tumor marker is primarily used as a marker for ovarian cancer

A

CA-125

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15
Q

This is found as a contaminant of homemade liquors and can cause optic neuropathy

A

Methanol

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16
Q

This is a significant environmental pollutant and is easily taken up by crops – especially tobacco

A

Cadmium

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17
Q

This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test

A

Digoxin

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18
Q

The most direct and effective route of administration of a drug

A

IV

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19
Q

This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine

A

Neuroblastoma

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20
Q

This test is used along with hCG to classify nonseminomatous tumor

A

AFP

21
Q

This is a kind of testing method that can be performed on solid tissue tumor markers

A

Immunohistochemistry

22
Q

The predicted dose that would produce a toxic response in 50% of the population

A

TD50

23
Q

This may occur when analyte concentrations exceed the analytical range excessively

A

Hook Effect

24
Q

This drug is the hepatic metabolite of procainamide

A

NAPA

25
Q

The study of the movement of drugs in the body

A

Pharmacokinetics

26
Q

This drug commonly is tested for both the total and free forms

A

Phenytoin (Dilantin)

27
Q

Endogenous substances biologically synthesized either in living cells or in microorganisms

A

Toxins

28
Q

This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer

A

CEA

29
Q

Uses the results from animal experiments to predict what level of exposure will cause harm to humans

A

Descriptive Toxicology

30
Q

This is a metal with 3 forms, one of which is liquid at room temp

A

Mercury

31
Q

This is a useful system to compare relative toxicities of substances as the predicted endpoint is death

A

Dose-Response Relationship

32
Q

B-macroglobulin and immunoglobulins are part of this group of tumor markers

A

Serum Protein Tumor Markers

33
Q

Chemicals and drugs that are not normally found in or produced by the body

A

Xenobiotics

34
Q

“Trace Element Free”

A

Royal Blue Top Tube

35
Q

This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody

A

HAMAs

36
Q

This drug is ototoxic enough that it is recommended that baseline audiology testing is performed

A

Tobramycin

37
Q

This type of tumor marker can help to choose between endocrine and cytotoxic therapies

A

Receptor Tumor Marker

38
Q

Tumor marker methodology include all of the following except:

Immunoassays
Gas chromatography
Immunohistochemistry
Enzyme analysis

A

Gas chromatography

39
Q

Which of the following tumor markers is classified as an oncofetal antigen?

Carcinoembryonic antigen (CEA)
CA 19-9
BRCA-1
hCG

A

Carcinoembryonic antigen (CEA)

40
Q

Which tumor marker is associated with neuroblastoma?

CA-15-3
Carcinoembryonic antigen (CEA)
CA 125
Homovanillic acid (HVA)

A

Homovanillic acid (HVA)

41
Q

Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results

True
False

A

False

42
Q

Elucidates cellular, molecular, and biochemical effects of xenobiotics within context of dose-response relationship between the xenobiotic and its adverse effects

A

Mechanistic toxicology

43
Q

Toxicology specialty that is primarily concerned with medical and legal consequences of exposure; used to generate evidence in legal situations

A

Forensics

44
Q

Treats GPC and GPB, one of its adverse effects is “redman’s syndrome”

A

Vancomycin

45
Q

Its effect is reduced when its taken with antacids; antiepileptic that also works as analgesic

A

Gabapentin

46
Q

Movement of a drug between blood circulation and tissues and organs, and the relative proportion of the drug in tissues

A

Drug distribution

47
Q

Included drugs in a screening panel (ABBCOTT)

A

Amphetamines
Barbiturates
Benzodiazepines
Cocaine
Opioids
THC
Tricyclic antidepressants

48
Q

Commonly used to detect hormones and metabolites secreted by tumors

A

High Performance Liquid Chromatography (HPLC)

Chem 1 (6 decks)

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