Wk 8 quiz, Wk 9 quiz, Exam 3 review bingo

Question 1

Which of the following statements is NOT true concerning testing for drugs of abuse?

-A two-tired testing approach includes screening and confirmatory testing
-Confirmatory testing must use methods with high specificity and low sensitivity
-Screening tests detect classes of drugs
-GC-MS is the reference method used for confirmation

Answer 1

Confirmatory testing must use methods with high specificity and low sensitivity

Question 2

Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.

-True
-False

Answer 2

True

Question 3

Which of the following is NOT true concerning analysis of toxic agents?

-Screening tests have good specificity but lack sensitivity
-Confirmatory tests report the concentration of the analyte
-Screening tests are a rapid test intended to detect the presence of a substance
-The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS)

Answer 3

Screening tests have good specificity but lack sensitivity

Question 4

Toxic levels of acetaminophen are associated with:

-Ototoxicity
-Nephrotoxicity
-Hepatotoxicity
-Neurotoxicity

Answer 4

Hepatotoxicity

Question 5

Pharmacokinetics and drug concentration are influenced by which of the following factors?

-Absorption, distribution, excretion, metabolism
-Absorption, bioavailability, excretion, metabolism
-Biotransformation, distribution, excretion, metabolism
-Adaption, distribution, excretion, metabolism

Answer 5

Absorption, distribution, excretion, metabolism

Question 6

A drug’s most direct and effective method of delivery to its site of action is:

-Oral administration
-Intramuscular injection
-Intravenous administration
-Aerosol ingestion

Answer 6

Intravenous administration

Question 7

A blood draw to determine a peak level of a drug should be drawn:

-One hour after an orally administered dose
-Immediately after drug administration
-90 minutes after an orally administered dose
-Immediately before drug administration

Answer 7

One hour after an orally administered dose

Question 8

Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.

-True
-False

Answer 8

True

Question 9

The major transporter of drugs

Answer 9

Albumin

Question 10

The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system

Answer 10

First Pass Effect

Question 11

The study of the biochemical and physiological effects of drugs and their mechanisms of actions

Answer 11

Pharmacodynamics

Question 12

This tumor marker often is measured in both the total and free form

Answer 12

PSA

Question 13

The concentration range of a drug within which the drug produces the desired effect

Answer 13

Therapeutic Range

Question 14

This tumor marker is primarily used as a marker for ovarian cancer

Answer 14

CA-125

Question 15

This is found as a contaminant of homemade liquors and can cause optic neuropathy

Answer 15

Methanol

Question 16

This is a significant environmental pollutant and is easily taken up by crops – especially tobacco

Answer 16

Cadmium

Question 17

This is a cardioactive drug that is used to treat arrythmias and CHF. Biotin is known to interfere with this test

Answer 17

Digoxin

Question 18

The most direct and effective route of administration of a drug

Answer 18

IV

Question 19

This is a common malignant tumor in kids associated with high levels of plasma, epinephrine, norepinephrine and dopamine

Answer 19

Neuroblastoma

Question 20

This test is used along with hCG to classify nonseminomatous tumor

Answer 20

AFP

Question 21

This is a kind of testing method that can be performed on solid tissue tumor markers

Answer 21

Immunohistochemistry

Question 22

The predicted dose that would produce a toxic response in 50% of the population

Answer 22

TD50

Question 23

This may occur when analyte concentrations exceed the analytical range excessively

Answer 23

Hook Effect

Question 24

This drug is the hepatic metabolite of procainamide

Answer 24

NAPA

Question 25

The study of the movement of drugs in the body

Answer 25

Pharmacokinetics

Question 26

This drug commonly is tested for both the total and free forms

Answer 26

Phenytoin (Dilantin)

Question 27

Endogenous substances biologically synthesized either in living cells or in microorganisms

Answer 27

Toxins

Question 28

This tumor marker is the prototypical oncofetal antigen and is used for monitoring colorectal cancer

Answer 28

CEA

Question 29

Uses the results from animal experiments to predict what level of exposure will cause harm to humans

Answer 29

Descriptive Toxicology

Question 30

This is a metal with 3 forms, one of which is liquid at room temp

Answer 30

Mercury

Question 31

This is a useful system to compare relative toxicities of substances as the predicted endpoint is death

Answer 31

Dose-Response Relationship

Question 32

B-macroglobulin and immunoglobulins are part of this group of tumor markers

Answer 32

Serum Protein Tumor Markers

Question 33

Chemicals and drugs that are not normally found in or produced by the body

Answer 33

Xenobiotics

Question 34

"Trace Element Free"

Answer 34

Royal Blue Top Tube

Question 35

This is an example of something that can have significant interference in immunoassays by cross-linking with the capture/label antibody

Answer 35

HAMAs

Question 36

This drug is ototoxic enough that it is recommended that baseline audiology testing is performed

Answer 36

Tobramycin

Question 37

This type of tumor marker can help to choose between endocrine and cytotoxic therapies

Answer 37

Receptor Tumor Marker

Question 38

Tumor marker methodology include all of the following except: Immunoassays Gas chromatography Immunohistochemistry Enzyme analysis

Answer 38

Gas chromatography

Question 39

Which of the following tumor markers is classified as an oncofetal antigen? Carcinoembryonic antigen (CEA) CA 19-9 BRCA-1 hCG

Answer 39

Carcinoembryonic antigen (CEA)

Question 40

Which tumor marker is associated with neuroblastoma? CA-15-3 Carcinoembryonic antigen (CEA) CA 125 Homovanillic acid (HVA)

Answer 40

Homovanillic acid (HVA)

Question 41

Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results True False

Answer 41

False

Question 42

Elucidates cellular, molecular, and biochemical effects of xenobiotics within context of dose-response relationship between the xenobiotic and its adverse effects

Answer 42

Mechanistic toxicology

Question 43

Toxicology specialty that is primarily concerned with medical and legal consequences of exposure; used to generate evidence in legal situations

Answer 43

Forensics

Question 44

Treats GPC and GPB, one of its adverse effects is "redman's syndrome"

Answer 44

Vancomycin

Question 45

Its effect is reduced when its taken with antacids; antiepileptic that also works as analgesic

Answer 45

Gabapentin

Question 46

Movement of a drug between blood circulation and tissues and organs, and the relative proportion of the drug in tissues

Answer 46

Drug distribution

Question 47

Included drugs in a screening panel (ABBCOTT)

Answer 47

Amphetamines Barbiturates Benzodiazepines Cocaine Opioids THC Tricyclic antidepressants

Question 48

Commonly used to detect hormones and metabolites secreted by tumors

Answer 48

High Performance Liquid Chromatography (HPLC)