Wk 6 Deck 1 Flashcards
dorsal
back
anterior
head
posterior
tail
ventral
belly
when are the axes setup in development?
very early
what gene specifies eye development for humans and flies
Pax6
in humans and insects, does the same gene specify the formation of an eye?
yes, Pax 6
by inserting a human Pax6 gene into a fruitfly leg, what happens
the regulatory switch gene forms a fruitfly eye, not a human eye
as an embryo develops, a ________ system is formed
coordinate system
the _______ gene determines if you’re in the right anterior/posterior place
Hawkes gene
in embryonic development, information is received from info in the ____ and the _____
egg and genome
cells in development become _________ specialized
progressively
2 general ways that daughter cells can differentiate
- asymmetric division(intrinsic), cells are born different,;
- symmetric division(extrinsic), sister cells become different as result of influences acting on them after birth (close range signals)
proper spindle ________ is required for an asymmetric outcome
orientation
localization ofa cell fate determinant in yeast involves RNP particles, _______ and the _____ _________
a motor, actin cytoskeleton
yeast makes a mating type _____, with allows conjugation, restoring _______
switch, diploidy
how is the switch in yeast initiated?
HO initiates the switch, by making a cut in the dna
Ash1 ______ the expression of the nuclease (HO) in the daughter yeast cell
inhibits
Ash1 is a _____ _______
transcriptional repressor
asymmetric localization of ASH1 requires an _____ -______
actin cytoskeleton
ORF
open reading frame
UTR
untranslated region
3’ UTR removal from ASH1 mrna ______ polar aggregation of rna
inhibited
how is the ASH1 mRNA moved from one to side of the cell to another
myosin (myo4P) binds to She2 and She3 and carries the mRNA to one side of the cell by binding to a target sequence on the URT tail of the Ash1 mRNA
