2-18-17 Flashcards
it’s not birth, marriage, or death, but _______ which is truly the most important moment of your life
gastrulation
skin and nervous - formed during gastrulation
ectoderm
respiratory and digestive - formed in gastrulation
endoderm
connective tisseu, blood, heart - formed during gastrulation
mesoderm
week one embryonic development events
fertilization, morula, blastocycst, implantation
polyspermy-
multiple sperm
zona pellucida
translucent layer around Oocyte, sperm attachment site, protects zygote, implantation to the uterus
Oocyte
egg+sperm??
acrosomal vesicle was originally derived from______
golgi
how does one sperm recognize an Oocyte
specific receptor on head of sperm that recognize zona pellicula
how is polyspermy prevented
binding increases opening of sodium channels and release of cortical granules
activation of sperm
exocytosis of the acrosomal vesicle (containing proteases)
4 key steps of fertilization
- binding of sperm 2. acrosomal reaction 3. penetration through zona pellucida 4. fusion of plasma membranes 5 sperm nucleaus enters egg cytoplasm.
cleavage begins about ______ hours post fertilization
30
blastomeres are ________
totipotent
cleavage leads to _______of the ________
compaction , morula
the morula is tightly adhered within the ________ __________
zona pellucida
blastomere is _____ the blastula
before
how many cells in a blastomere?
1
totipotency synonym
multipotency
the first cell differentiation event takes place in the __________
blastocyst
parts of a blastocyst
blastocoel, zona pellucida, inner cell mass, trophoblast
what portion of the blastocyst forms the embryo?
the inner cell mass
Oct4 protein is expressed in the _______ cells of the __________
pluripotent ICM
totipotent
can give rise to any other cell in the body
pluripotent
can give rise to more than one other cell in the body
you can make a cell pluripotent by the introduction of _____ _________
transcription factors
we all _____ as embryos
hatch
we hatch from the _____ ______
zona pellucida
the chorion enables_______
the fetus to get oxegen and nutrients from the mother
syntrhophoblast
multiple nuclei and ……
3 types of monozygotic twins
unique chorion, shared chorion- ok, shared chorion-possible conjoined
cyncytiotrophoblast
intermediary trophoblast with finger like projections
ICM’s form originally into a _____ _______
bilaminar disc
epiblast
part of the bilaminar disc
hypoblast cells
part of the bilaminar disc
connecting stalk connects to the _______
umbilical cord
the hypoblast is pushed away to form the ______
endoderm
top down order of first layers
ecto, meso, endoderm
almost 2/3 of fertilized embyos ______
terminate
how do you go from a sheet of cells into something as complex as a brain?
shaping, folding, closure
MHP
medial hinge points
folic acid supplements can prevent what?
50% of neural closure defects