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Pathopharmacology II > Wk 4 Guillain-Barre > Flashcards

Wk 4 Guillain-Barre Flashcards

1
Q

How do you say Guillain-Barre Syndrome?

A

Gee-anne buh-ray

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2
Q

What is Guillain-Barre syndrome aka?

A

Acute ascending polyneuritis

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3
Q

Guillain-Barre is an __ disorder

A

autoimmune

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4
Q

What happens in Guillain-Barre syndrome?

A

Myelin sheath is damaged due to autoantibodies

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5
Q

What is the role of the myelin sheath?

A

Covering of axons that transmit nerve impulses, making the transmission fast and smooth

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6
Q

Most patients who develop Guillain-Barre syndrome had a __ __ several weeks ago

A

viral infection

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7
Q

The viral infection usually is of the __ or __ tract

A

respiratory or GI

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8
Q

What are three potential etiologies of Guillain-Barre syndrome?

A

Viral infection
Bacterial infection
Post-surgery (5-10%)

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9
Q

What bacterium has been associated with Guillain-Barre syndrome?

A

Camplylobacter jejuni (food-borne illness)

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10
Q

What other rare etiology is associated with Guillain-Barre sydrome?

A

Flu vaccine

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11
Q

Guillain-Barre syndrome usually manifests in what way?

A

Lower extremities and ascends up the body

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12
Q

As a person recovers from Guillain-Barre syndrome, what direction does this happen?

A

In the opposite direction, a descending pattern

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13
Q

What are the clinical manifestations of Guillain-Barre syndrome?

A

Tingling/weakness to paralysis

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14
Q

Severity of symptoms increases over __ to __

A

hours to days

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15
Q

What is so severe about Guillain-Barre syndrome?

A

It’s potentially life threatening if respiratory muscles are involved

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16
Q

What might a patient with Guillain-Barre syndrome need if they are suffering from respiratory deficiency

A

Tracheostomy

17
Q

What are the s/s of Guillain-Barre?

A 
Uncoordinated movements
Decreased sensation/tingling 
Loss of bowel/bladder control
Blurred vision
Difficulty breathing, chewing, swallowing
18
Q

This is no __ for Guillain-Barre

A

Cure

19
Q

What is the goal of pharmacotherapy concerning Guillain-Barre?

A

Reduce severity and accelerate recovery

20
Q

What is the acute phase of Guillain-Barre treated with?

A

Steroids

High dose IV immunoglobulin therapy

21
Q

What are the benefits of high-dose IV immunoglobulin therapy?

A

Shortens illness duration and hospital stay

22
Q

What are the recurrences of this syndrome?

A

Some patients will have it only once in their lifetime, others will have recurrences (3%)

23
Q

What is the prognosis of Guillain-Barre syndrome?

A

95% survive

24
Q

What percentage of patients with Guillain-Barre completely recover?

A

75%

25
Q

About 30% of patients who have had Guillain-Barre syndrome will experience __ __ after 3 years

A

residual weakness

Pathopharmacology II (12 decks)

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