Wk 13: Thyroid therapeutic Flashcards
1
Q
Outline the thyroid hormone action
A
- T3 interacts w/ thyroid hormone receptors
- Nuclear hormone receptors
- Dimerize w/ retinoid receptor
- Bind to DNA
- Transcribe target genes
- Elicit desired effects
2
Q
Outline the process of thyroid scanning
A
- Patients ingest radioactive iodine
- 4hrs later: scan w/ gamma probe
- Measures how much radioactive iodine is taken up by thyroid gland
3
Q
What is the mechanism of carbimazole?
A
Thyroid peroxidase inhibitor
- Red oxidation iodide -> iodine
- Red organification of iodine -> iodotyrosine
- Inhibits coupling iodotyrosine
4
Q
What is the mechanism of propylthiouracil?
A
Thyroid peroxidase inhibitor
- Red oxidation iodide -> iodine
- Red organification of iodine -> iodotyrosine
- Inhibits coupling iodotyrosine
5
Q
Which drug is used during pregnancy?
A
PTU bc carb = teratogenic effect
6
Q
Which drug is preferred when breast feeding?
A
Carb bc less hepatotoxicity
7
Q
What drug can be used to treat thyrotoxicosis?
A
Propranolol
