Wk 11: Managing steroids in practice: Non-oral route Flashcards
1
Q
What is the mechanism of action of intra-articular steroid injections?
A
- Insoluble/long-acting steroid remains in joint
- Contact w/ inflamed synovial surface
- Taken up by synovial cells
- Absorbed in bloodstream
2
Q
Give examples of intra-articular steroid injections
A
- Triamcinolone
- Methylprednisolone
- Dexamethasone
3
Q
What is prolonged steroid injection associated with?
A
Osteonecrosis
4
Q
Give an example of a very potent topical corticosteroid
A
Clobetasol
5
Q
Give an example of a potent topical corticosteroid
A
- Betamethasone dipropionate
- Beclometasone
- Hydrocortisone butyrate 0.1%
6
Q
Give an example of a moderate topical corticosteroid
A
- Alclometasone dipropionate 0.05% Cream (All formulations)
- Betamethasone 0.025% (betnovate RD)
- Clobetasone
7
Q
Give an example of a mild topical corticosteroid
A
Hydrocortisone 1% + 2.5% all formulations
8
Q
What are the side effects of topical steroids?
A
- Spread worsening of untreated infection (not on infected skin unless specific treatment for infection given)
- Thinning of skin w/ LT use
- Contact dermatitis
- Acne
- Depigmentation
- Hypertrichosis
9
Q
What are the systemic effects of inhaled corticosteroids at high doses?
A
- Adrenal suppression
- Reduced bone mineral density
- Growth retardation
- Lower respiratory tract infection
