Witrak: Breast Pathology Flashcards
young breast: largely _____ (fribrous or adipose) stroma
fibrous
older breast: largely ____ (fibrous or adipose) stroma
adipose
where is the source of most breast cancers/diseases?
epithelium
proximal duct system (closer to nipple) (ex. papilloma) is usually ______ (benign/malignant)
benign
what can simulate breast cancer and needs a biopsy to tell the difference? can be associated with a car accident and trauma to the breast and hemorrhage
fat necrosis
what would be the ddx for erythematous breast skin rupture?
bacterial mastitis (lactation), dermatitis, inflammatory breast cancer (plugs up dermal lymphatics)
what is the commonest benign tumor of the breast?
fibroadenoma
what is the commonest disease of the breast (60% of women) that shows cystic change and epithelial hyperplasia
fibrocystic disease
what is the difference between in-situ breast carcinoma and invasive?
in-situ is curable and invasive is where the basement membrane is eroded-> lymphatic invasion and dissemination.
what breast lesion represents a ‘staghorn ductal epithelium’?
fibroadenoma
what system is the source of 90% of breast cancer? (lobule/terminal or duct)
DUCT
spherical calcified lesion in the breast: either fat necrosis or fibroadenoma?
fat necrosis- lipid layden macrophages and overtime, calcification of the breast can occur
In DCIS (ductal carcinoma in-situ), where is the invasive cancer usually going to be? (ipsilateral OR contralateral)
within the same area- ipsilateral and same quadrant
LCIS (lobular carcinoma in-situ), where is the invasive cancer usually going to be? HOW DO YOU TREAT THIS ONE?
IT CAN BE IN THE OTHER BREAST (EQUAL BILATERALLY). SYSTEMIC ESTROGEN SUPPRESSION OR BILATERAL BREAST REMOVAL.
what should you consider when you see a weepy xematoid crusty look to the nipple?
BREAST CANCER.
what has a higher relative risk- postmenopausal unilateral (family hx) or premenopausal bilateral (family hx)?
Premopausal bilateral (9) vs, postmenopausal unilateral (1.2-3)
is the father important in taking a family history for breast cancer risk?
yes, apparently his genetics (BRCA-specific) can influence it. maybe different than what ONELLO WAS TALKING ABOUT?
is hereditary breast cancer the majority cause of cancer?
NO. 5-10% of ALL breast cancer
what is the commonest cancer in women in the USA?
breast cancer
how does breast cancer rank compared to lung cancer as the cause of cancer death in american women?
lung cancer. breast cancer
T or F: a breast lump is cancer until proven otherwise
T
what is the ‘gold standard’ for diagnosis of a lump?
open surgical biopsy
if you have a suscpisiouc worrisome lesion, what is the current standard first biopsy procedure?
stereostactic needle core breast biopsy
when would you use a fine needle aspiration?
confirming clinically benign cyst disease or clinically obvious cancer
